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Leyin Wu

ORCID: 0009-0006-9099-1283
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A5081714637
Research Areas
  • Cancer, Stress, Anesthesia, and Immune Response
  • Advanced Breast Cancer Therapies
  • Receptor Mechanisms and Signaling
  • Cancer Cells and Metastasis
  • Hormonal Regulation and Hypertension
  • Bioactive Compounds and Antitumor Agents
  • Genomics, phytochemicals, and oxidative stress

China Pharmaceutical University
 2023-2024

 FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway
OPENALEX - Publications 
Yunjiang Zhou Yaxin Chen Yongwei Shi Leyin Wu Yingying Tan and 4 more Tao Li Yi-Gang Chen Jiazeng Xia Rong Hu

Gastric cancer often shows malignant growth and insensitivity to chemotherapeutic drugs due the regulation of complex molecular mechanisms, which results in poor prognosis for patients. However, relevant mechanisms remain unclear. In this study, we reported that family with sequence similarity 117, member B (FAM117B), promoted gastric cells reduced sensitivity drugs. Mechanistically, FAM117B competed nuclear factor E2–related 2 (NRF2) Kelch-like ECH-associated protein 1 (KEAP1) binding,...

10.1172/jci158705 article EN cc-by Journal of Clinical Investigation 2023-01-31
 Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired migration cell, well...

10.1158/1541-7786.mcr-23-0513 article EN Molecular Cancer Research 2024-02-21
 Data from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<div>Abstract<p>A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired...

10.1158/1541-7786.c.7267998 preprint EN 2024-06-04
 Supplementary Figure S11 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S11 and its legend.</p>

10.1158/1541-7786.25964919 preprint EN cc-by 2024-06-04
 Supplementary Figure S14 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S14 and its legend.</p>

10.1158/1541-7786.25964907.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S9 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S9 and its legend.</p>

10.1158/1541-7786.25964862.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S4 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S4 and its legend.</p>

10.1158/1541-7786.25964877.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S13 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S13 and its legend.</p>

10.1158/1541-7786.25964910.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S20 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S20 and its legend.</p>

10.1158/1541-7786.25964883.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S10 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S10 and its legend.</p>

10.1158/1541-7786.25964922.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S1 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S1 and its legend.</p>

10.1158/1541-7786.25964925 preprint EN cc-by 2024-06-04
 Supplementary Figure S18 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S18 and its legend.</p>

10.1158/1541-7786.25964895.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S15 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S15 and its legend.</p>

10.1158/1541-7786.25964904.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S16 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S16 and its legend.</p>

10.1158/1541-7786.25964901.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S5 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S5 and its legend.</p>

10.1158/1541-7786.25964874.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S11 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S11 and its legend.</p>

10.1158/1541-7786.25964919.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S7 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S7 and its legend.</p>

10.1158/1541-7786.25964868.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S1 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S1 and its legend.</p>

10.1158/1541-7786.25964925.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S8 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S8 and its legend.</p>

10.1158/1541-7786.25964865.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S17 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S17 and its legend.</p>

10.1158/1541-7786.25964898.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S12 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S12 and its legend.</p>

10.1158/1541-7786.25964916.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S6 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S6 and its legend.</p>

10.1158/1541-7786.25964871.v1 preprint EN cc-by 2024-06-04
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