Chenyuan Xuan

ORCID: 0000-0003-3251-5191
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Research Areas
  • Cancer, Stress, Anesthesia, and Immune Response
  • Advanced Breast Cancer Therapies
  • Cancer Immunotherapy and Biomarkers
  • Cytokine Signaling Pathways and Interactions
  • Cancer Cells and Metastasis
  • Synthesis and biological activity
  • Genomics, phytochemicals, and oxidative stress
  • interferon and immune responses
  • Autophagy in Disease and Therapy
  • Solar Radiation and Photovoltaics
  • Tryptophan and brain disorders
  • RNA Interference and Gene Delivery
  • Immune cells in cancer
  • Macrophage Migration Inhibitory Factor
  • Viral Infections and Vectors
  • Renal Diseases and Glomerulopathies
  • Atmospheric aerosols and clouds
  • Urban Heat Island Mitigation
  • Cell Adhesion Molecules Research
  • Peptidase Inhibition and Analysis
  • Nanoparticle-Based Drug Delivery
  • Cancer therapeutics and mechanisms
  • Bioactive Compounds and Antitumor Agents
  • Receptor Mechanisms and Signaling
  • CAR-T cell therapy research

Anyang Hospital of Traditional Chinese Medicine
2025

China Pharmaceutical University
2023-2024

Beijing Meteorological Bureau
2014

A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired migration cell, well...

10.1158/1541-7786.mcr-23-0513 article EN Molecular Cancer Research 2024-02-21

Chemotherapy has been the standard treatment for liver cancer. However, intrinsic or acquired drug resistance remains a major barrier to successful treatment. At present, underlying molecular mechanisms of chemoresistance in cancer have not elucidated. Dipeptidyl peptidase 9 (DPP9) is member dipeptidyl IV family that found be highly expressed variety tumors, including It unclear whether DPP9 affects In this study, we find weakens responses cells chemotherapy drugs by up-regulating NQO1 and...

10.1016/j.redox.2024.103292 article EN cc-by Redox Biology 2024-07-29

Despite aggressive treatment, the recurrence of glioma is an inevitable occurrence, leading to unsatisfactory clinical outcomes. A plausible explanation for this phenomenon phenotypic alterations that cells undergo therapies, such as TMZ-therapy. However, underlying mechanisms behind these changes are not well understood.

10.1016/j.drup.2024.101112 article EN cc-by-nc-nd Drug Resistance Updates 2024-06-24

To investigate the protective effect of Yiqi Yangyin Huazhuo Tongluo Formula (YYHT) against high glucose-induced injury in mouse renal podocytes (MPC5 cells) and possible mechanism. Adult Wistar rats were treated with 19, 38, 76 g/kg YYHT or saline via gavage for 7 days to prepare YYHT-medicated blank sera treatment MPC5 cells cultured glucose (30 mmol/L) prior transfection a miR-21a-5p inhibitor mimic. The changes expressions mRNA levels FoxO1, PINK1, Parkin detected qRT-PCR, protein...

10.12122/j.issn.1673-4254.2025.01.04 article EN PubMed 2025-01-20

ABSTRACT Using surface meteorological data at 20 sites in Beijing area during 1961–2007, the variability and trend of solar radiation ( SSR ) their potential drivers were investigated. Cloud cover was an important factor determining interannual variation reflected linear correlation coefficients R ranged from −0.65 to −0.89) between variations cloud cover. Aerosol optical depth AOD also contributed , as shown by negative correlations −0.44 −0.81). decreased 2.29 (winter), 3.63 (spring), 7.45...

10.1002/joc.3994 article EN International Journal of Climatology 2014-03-29

<div>Abstract<p>A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired...

10.1158/1541-7786.c.7267998 preprint EN 2024-06-04
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