A5059266274- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Breast Cancer Therapies
- Synthetic Organic Chemistry Methods
- Cancer Treatment and Pharmacology
- Microbial Natural Products and Biosynthesis
- Animal Disease Management and Epidemiology
- Advanced Synthetic Organic Chemistry
- Receptor Mechanisms and Signaling
- Origins and Evolution of Life
- DNA and Nucleic Acid Chemistry
- Animal Virus Infections Studies
- Chemical synthesis and alkaloids
- Synthesis and Catalytic Reactions
- Cancer Cells and Metastasis
- Synthesis of Indole Derivatives
- Marine Sponges and Natural Products
- Bioactive Compounds and Antitumor Agents
- Bacteriophages and microbial interactions
- DNA and Biological Computing
China Pharmaceutical University
2024
Nankai University
2007
Scripps Research Institute
1994-1998
University of California, San Diego
1994-1998
A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired migration cell, well...
Isolated from certain species of soft corals, the sarcodictyins, eleutherobin, and eleuthosides have become important synthetic targets due their novel molecular architectures, biological activities, potential in medicine. Of particular interest is Taxol-like mechanism action involving disturbance tubulin−microtubule interplay resulting tumor cell death. Their scarcity profile prompted us to initiate a program directed at exploring chemical synthesis biology. Herein we report (a) first total...
The attack of a thiolate ion on the trisulfide unit natural calicheamicin γ (1) activates it to form diradical, which then attacks DNA. Thioacetate 2 is even more readily activated—under mildly basic conditions caused by OH- ions—and likewise exhibits extremely interesting biological properties.
<div>Abstract<p>A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired...
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