A5083588439- Pulsars and Gravitational Waves Research
- Gamma-ray bursts and supernovae
- Rheumatoid Arthritis Research and Therapies
- Astrophysical Phenomena and Observations
- Geophysics and Gravity Measurements
- Cosmology and Gravitation Theories
- Spondyloarthritis Studies and Treatments
- High-pressure geophysics and materials
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders Research
- Astrophysics and Cosmic Phenomena
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Lymphocytic Leukemia Research
- Atomic and Subatomic Physics Research
- Radio Astronomy Observations and Technology
- Psoriasis: Treatment and Pathogenesis
- Magnetic confinement fusion research
- Adaptive optics and wavefront sensing
- Dark Matter and Cosmic Phenomena
- Lymphoma Diagnosis and Treatment
- Superconducting Materials and Applications
- Pneumonia and Respiratory Infections
Istituto Nazionale di Fisica Nucleare, Roma Tor Vergata
2020-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2025
University of Rome Tor Vergata
2020-2024
Université Paris Cité
2023
Laboratoire AstroParticule et Cosmologie
2023
Centre National de la Recherche Scientifique
2023
National Institute for Subatomic Physics
2022
University of Trento
2022
AbbVie (United States)
2013-2015
Abbott Fund
2004-2013
To evaluate the effects of adalimumab on patient-reported outcomes joint-related and skin-related functional impairment, health-related quality life, fatigue pain in patients with psoriatic arthritis (PsA).Patients moderately- to severely- active PsA were treated adalimumab, 40 mg, every other week, or placebo, this 24-week, randomised, controlled trial. Patient-reported included Health Assessment Questionnaire Disability Index (HAQ DI), Short-Form 36 Survey (SF-36), Functional Chronic...
Abstract The three advanced Virgo and LIGO gravitational wave detectors participated to the third observing run (O3) between 1 April 2019 15:00 UTC 27 March 2020 17:00 UTC, leading several detections per month. This paper describes detector calibration reconstruction of strain h ( t ) during O3, as well estimation associated uncertainties. For first time, photon technique been used reference for calibration, which allowed cross-calibrate amplitude detectors. previous reference, so-called...
The quantum radiation pressure and the shot noise in laser-interferometric gravitational wave detectors constitute a macroscopic manifestation of Heisenberg inequality. If can be easily observed, observation has been elusive, so far, due to technical competing with effects. Here, we discuss evidence Advanced Virgo detector. In our experiment, inject squeezed vacuum states light into interferometer order manipulate backaction on 42 kg mirrors observe corresponding driven displacement at...
Optical aberrations represent a critical issue for gravitational wave interferometers, as they impact the stability and controllability of experiment. In next generation detectors, circulating power in cavity arms is expected to increase by up factor 20 compared current ones. This significant makes mitigation power-dependent optical extremely challenging. this paper, we describe problem absorption optics its role generating some most important wavefront distortions, along with present...
Rheumatoid arthritis (RA) causes considerable disability and often results in loss of work capacity productivity. This study evaluated the impact adalimumab, a tumour necrosis factor antagonist with demonstrated efficacy RA, on long-term employment.Data from an open-label extension (DE033) 486 RA patients receiving adalimumab monotherapy who previously did not respond to at least one disease-modifying antirheumatic drug (DMARD) had baseline status information were compared data 747 DMARD...
Objectives. This study evaluated the patients’ perspective of burden disease among 505 patients with severe, long-standing rheumatoid arthritis receiving adalimumab. Methods. Health-related quality-of-life and resource use data were collected during a 144-week open-label study. Results. Adalimumab maintained pain control reduced duration morning stiffness. Work impairment decreased work productivity was over Costs estimated at ∼€2100 course study, personal help transportation costs comprised...
<h3>Objective</h3> To estimate the overall economic burden of pneumonia from an employer perspective. <h3>Methods</h3> The annual, per capita cost was determined for beneficiaries a major by analyzing medical, pharmaceutical, and disability claims data. incremental costs 4036 patients with diagnosis identified in health database national Fortune 100 company were compared 10% random sample population. <h3>Results</h3> Total capita, approximately 5 times higher ($11 544) than among typical...
Objective: Treatment of chronic obstructive pulmonary disease (COPD) is based on symptom control. This suggests that COPD severity can be determined by analyzing treatment intensity. The objective this analysis was to develop and validate a score for adult treatments.Research design: Using principal components analysis, developed using data treatments extracted from an employer claims database (development group). Variables included were identified literature review clinical expert opinion....
Abstract Earth-based gravitational waves interferometric detectors are shot-noise limited in the high-frequency region of their sensitivity band. While enhancing laser input power is natural solution to improve on shot noise limit, higher also increases optical aberration budget due absorption highly reflective coatings mirrors, resulting a drop detector. Advanced Virgo exploits Hartmann Wavefront Sensors (HWSs) locally measure absorption-induced aberrations by monitoring path length change...
Objective To estimate the cost-effectiveness of adalimumab plus methotrexate (MTX) versus MTX monotherapy in early, aggressive rheumatoid arthritis (RA) when explicitly modelling short-term (reversible) and long-term (irreversible, ie, joint damage) disease activity physical function. Methods A microsimulation model was developed to unify, a single model, measures reversible irreversible function based on data from PREMIER trial. Short term, modelled using DAS28 variables, including swollen...
<h3>Background</h3> Within 2 to 3 years of disease, approximately 20 30% patients with early rheumatoid arthritis (RA) become permanently work disabled (Allaire, 2008). Disability-associated ‘work instability’ defined as the mismatch between their functional capabilities and job demands, is a risk factor for loss employment. The RA-WIS was developed assess level disability in RA patients; however there limited information on its responsiveness minimal important difference (MID)....
Optical aberrations represent a critical issue for gravitational wave interferometers, as they impact the stability and controllability of experiment. In next generation detectors, circulating power in cavity arms is expected to increase by up factor 20 compared current ones. This significant makes mitigation power-dependent optical extremely challenging. this paper, we describe problem absorption optics its role generating some most important wavefront distortions, along with present...
<h3>Background</h3> Axial spondyloarthritis (axSpA) is a new classification that includes ankylosing spondylitis (AS) and nonradiographic axSpA (nr-axSpA). Little known about the severity progressive nature of nr-axSpA relative to AS. An analysis German Spondyloarthritis Inception Cohort (GESPIC) indicated clinical manifestations disease activity measures are highly comparable between early AS.<sup>1</sup> We analyzed data from Phase III trials adalimumab in patients with AS compared results...
<h3>Background</h3> Rheumatoid arthritis (RA) itself, as well the disease-modifying drugs used to treat it, can have negative effects on various organ systems, manifesting specific laboratory abnormalities which must be monitored for patient safety. Tumor necrosis factor inhibitors (TNFi) are effective treating RA, but more data needed about their association with parameters of interest. <h3>Objectives</h3> This study was conducted investigate prevalence in patients RA who initiate treatment...
<h3>Background</h3> Increasing attention has been focused on patient-reported outcomes (PROs) and work productivity as important in RA. In the Optimal Protocol for Treatment Initiation with Methotrexate (MTX) Adalimumab (ADA) (OPTIMA) trial, results at 26 weeks (wks) showed a significant advantage of treatment ADA vs. placebo (PBO) achieving improved PROs. <h3>Objectives</h3> To evaluate impact discontinuation PROs productivity, variation these maintenance low disease activity (LDA), early...
Background: UK guidelines and a `Rheumatology' editorial suggest that liver function tests (LFTs) alone remain satisfactory method for methotrexate (MTX) monitoring in rheumatoid arthritis (RA). Recent literature also suggests no difference hepatotoxity between MTX treated RA psoriatic (PsA) patients. We describe 3 cases of fibrosis / cirrhosis missed by conventional monitoring. Methods: Case 1: 71 yr old female, 35 yrs. Presented 2005. Previous breast cancer. Alcohol < 1 unit/week. Rx 20...