A5101689414- Bioenergy crop production and management
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Immunotherapy and Immune Responses
- Biofuel production and bioconversion
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Ecology and Vegetation Dynamics Studies
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Agronomic Practices and Intercropping Systems
- Metal complexes synthesis and properties
- HIV/AIDS drug development and treatment
- Magnetism in coordination complexes
- Plant Pathogens and Resistance
- Mycobacterium research and diagnosis
- Supramolecular Chemistry and Complexes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer survivorship and care
- Genetic Mapping and Diversity in Plants and Animals
- Wildlife-Road Interactions and Conservation
National Taipei University of Nursing and Health Science
2025
National Taiwan University Hospital
2021-2025
The Ohio State University
2015-2023
Biology of Infection
2015
Tufts University
2014
National Taiwan University
1999-2013
Abstract High‐dimensional mass cytometry data potentially enable a comprehensive characterization of immune cells. In order to positively affect clinical trials and translational research, this advanced technology needs demonstrate high reproducibility results across multiple sites for both peripheral blood mononuclear cells (PBMC) whole preparations. A dry 30‐marker broad immunophenotyping panel customized automated analysis software were recently engineered are commercially available as...
Little is known about hepatitis B virus (HBV) diversity changes within a host during the immunotolerant phase of chronic HBV infection. Such knowledge, nevertheless, may help in understanding how immunity and interact at early stage In this study, serial serum samples were collected from long-term (>17 years) follow-up cohort seven patients, multiple copies full-length viral genome serially sampled sera recovered analyzed. Viral genetic was positively correlated with immunity, represented by...
Streptococcus mutans strongly influences the development of pathogenic biofilms associated with dental caries. Our understanding S. behaviour in is based on a few well-characterized laboratory strains; however, individual isolates vary widely genome content and virulence-associated phenotypes, such as biofilm formation environmental stress sensitivity. Using an ecological model, we assessed impact co-cultivation several oralis Actinomyces naeslundii composition following exposure to sucrose....
Anthropogenic disturbances often change ecological communities and provide opportunities for non-native species invasion. Understanding the impacts of on invasion is therefore crucial invasive management. We used generalized linear mixed effects models to explore influence land-use history distance roads occurrence abundance two plant (Rosa multiflora Berberis thunbergii) in a 900-ha deciduous forest eastern U.S.A., Powdermill Nature Reserve. Although much reserve has been continuously...
Three novel oligo-α-pyridylamino ligands, tripyridyldi-amine (H<sub>2</sub>tpda), tetrapyridyltriamine (H<sub>3</sub>teptra), pentapyridyltetramine (H<sub>4</sub>peptea) are synthesized; the crystal structures of their metal complexes with all-<italic>anti</italic> configuration chelating ligands reported.
Superspreading events (SSEs) are pivotal in the spread of SARS-CoV-2. This study aimed to investigate an SSE COVID-19 a hospital and explore transmission dynamics heterogeneity SSE. We performed contact tracing for all close contacts cluster. did nasopharyngeal or throat swabbing SARS-CoV-2 by real-time RT-PCR. Environmental survey was performed. The epidemiological clinical characteristics were studied. Patient 1 with congestive heart failure cellulitis, who had onset two weeks after...
The neonatal Fc receptor (FcRn) is responsible for recycling of IgG antibodies and albumin throughout the body. This mechanism has been exploited pharmaceutic delivery across an array diseases to either enhance or diminish this function. Monoclonal albumin-bound nanoparticles are examples FcRn-dependent anti-cancer therapeutics. Despite its importance in drug delivery, little known about FcRn expression circulating immune cells. Through time-of-flight mass cytometry (CyTOF) we were able...
Abstract To study interactions between host figs and their pollinating wasps the influence of climatic change on genetic structures, we sequenced cytoplasmic nuclear genes genotyped microsatellite loci from two varieties F icus pumila , widespread creeping fig endemic jelly fig, wasps, W iebesia pumilae found in Taiwan nearby offshore islands. Great divergence mitochondrial cytochrome c oxidase subunit I (mt COI ) with no admixture markers indicated that creeping‐ jelly‐fig are genetically...
Switchgrass ( Panicum virgatum ) has been planted extensively for habitat restoration across the United States, such as with Conservation Reserve Program (CRP). However, genetic profiles of these populations have never studied nor compared those remnant prairies or cultivars. In this study, we sampled 16 CRP and 17 prairie eastern Kansas. We assessed ploidy levels all diversity structure 10 prairies, areas, 5 standard cultivars, using nine simple sequence repeat (SSR) DNA markers. All were...
Cellular senescence is a durable cell cycle arrest as result of the finite proliferative capacity cells. Senescence responds to both intrinsic and extrinsic cellular stresses, such aging, mitochondrial dysfunction, irradiation, chemotherapy. Here, we report on use mass cytometry (MC) analyze multiple model systems demonstrate MC platform for analysis at single-cell level. We changes p16 expression, cycling fraction, histone tail modifications in several established senescent using isolated...
Ornamental grasses may become invasive weeds depending on their ability to naturalize and outcompete other species. Miscanthus sacchariflorus (Maxim) Franch. (Amur silvergrass) is a tall, self-incompatible, nonnative grass that has naturalized in eastern North America, forming monospecific stands raising concerns about its potential invasiveness. To understand the extent of clonal sexual reproduction feral populations, we examined population genetic structure, seed production, ploidy. We...
Abstract Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 virus-specific cytotoxic T-cell lymphocytes (vCTLs) could provide a promising modality in COVID-19 treatment. We aimed to screen, manufacture, and characterize SARS-CoV-2–vCTLs generated from convalescent donors using the CliniMACS Cytokine Capture System (CCS). Methods Donor screening was done stimulation of donor peripheral blood mononuclear cells...
<h3>Background</h3> Rheumatoid arthritis (RA) itself, as well the disease-modifying drugs used to treat it, can have negative effects on various organ systems, manifesting specific laboratory abnormalities which must be monitored for patient safety. Tumor necrosis factor inhibitors (TNFi) are effective treating RA, but more data needed about their association with parameters of interest. <h3>Objectives</h3> This study was conducted investigate prevalence in patients RA who initiate treatment...