A5013112469- Nuclear Physics and Applications
- Radiation Detection and Scintillator Technologies
- Particle Detector Development and Performance
- Radiation Therapy and Dosimetry
- Radioactivity and Radon Measurements
- Diamond and Carbon-based Materials Research
- Radiation Effects and Dosimetry
- Electrospun Nanofibers in Biomedical Applications
- Particle accelerators and beam dynamics
- Nuclear reactor physics and engineering
- Advanced Radiotherapy Techniques
- Ion-surface interactions and analysis
- Medical Imaging Techniques and Applications
- Radiation Effects in Electronics
- Electron and X-Ray Spectroscopy Techniques
- Analytical chemistry methods development
- Magnetic confinement fusion research
- Radiopharmaceutical Chemistry and Applications
- RNA Interference and Gene Delivery
- CCD and CMOS Imaging Sensors
- Cultural Heritage Materials Analysis
- Dark Matter and Cosmic Phenomena
- Nuclear physics research studies
- X-ray Spectroscopy and Fluorescence Analysis
- Geochemistry and Geologic Mapping
Czech Academy of Sciences, Nuclear Physics Institute
2015-2025
Czech Academy of Sciences
2013-2025
Nuclear Research Institute Rez (Czechia)
2019-2025
Czech Technical University in Prague
1996-1999
Abstract The miniaturized radiation camera MiniPIX TPX3 is designed for detailed and wide-range measurements of mixed-radiation fields present in many applications such as radiotherapy space outer orbit. highly integrated instrumentation utilizes a single connector control readout flexible quick deployment. device features an option to process the registered data on same with limited resolution basic particle-type resolving power. A novel processing technique exploits detector high...
We performed detailed measurements of the secondary cosmic ray field in lower atmosphere (at 200 m). use a miniaturised particle telescope consisting two closely stacked synchronised Timepix3 detectors. Position-, spectral-, and time-sensitive tracking provides enhanced particle-type resolving power high angular resolution mapping charged particles. Evaluation calibration directional response was with proton electron beams. The architecture, modeled developed data analysis provide accurate...
Reactivity towards low‐energy electrons (LEE) has been hypothesized as a cause of radio‐modifying properties for various molecules. LEE's transient nature, however, prevents the establishment clear links between initial processes at sub‐ps time scale and final products radiolysis. Here, such are explored compound RRx‐001 (1‐bromoacetyl‐3,3‐dinitroazetidine). Picosecond pulse radiolysis demonstrates high scavenging capacity molecule secondary quasi‐free solvated forming stable parent anions...
This work aims to characterize ultra high dose rate pulses (UHDpulse) electron beams using the hybrid semiconductor pixel detector. The Timepix3 (TPX3) ASIC chip was used measure composition, spatial, time, and spectral characteristics of secondary radiation fields from pulsed 15 23 MeV beams. challenge is develop a single compact detector that could extract spectrometric dosimetric information on such flux short fields. For beam measurements, PMMA plates 1 8 cm thickness were placed in...
Nano-optodes with a diamond core coated double stimuli-responsive polymeric shell reversibly respond to pH and temperature changes.
Abstract We evaluate a high-resolution contrast-enhanced method for energy-sensitive radiography of thin samples with low-energy protons at the light-ion Tandetron accelerator NPI-CAS in Rez near Prague. make use high-sensitivity hybrid semiconductor pixel detectors Timepix enabled by integrated per-pixel signal processing electronics. For this work we Timepix3 ASIC chip equipped 500 µm Si sensor operated fast data rate AdvaPix readout electronics interface. Measurements are performed air...
DNA origami nanoframes with two parallel sequences are used to evaluate the effect of nucleoside substituents on radiation-induced damage. Double strand breaks (DSB) counted using atomic force microscopy (AFM), and total number lesions is evaluated real-time polymerase chain reaction (RT-PCR). Enhanced AT or GC content does not increase breaks. Incorporation 8-bromoadenosine results in highest enhancement lesions; however, DSB observed for 2′-deoxy-2′-fluorocytidine, indicating different...
Due to their electromagnetic properties, thunderclouds can act as natural particle accelerators. Electrons accelerated in the reach energies up tens of MeV. Large populations high energetic electrons formed by avalanche growth driven electric fields Earth atmosphere called Relativistic Runaway Electron Avalanches (RREA) propagate through matter. They are decelerated and deflected course collisions with particles emit gamma rays known bremsstrahlung. The produced further trigger photonuclear...
The objective was to describe Microtron MT25 as a source of neutrons generated by bremsstrahlung induced photonuclear reactions in U and Pb targets. Bremsstrahlung photons were produced electrons accelerated at energy 21.6 MeV. Spectral fluence the calculated with MCNPX code then experimentally determined two positions means Bonner spheres spectrometer which detector thermal replaced activation Mn tablets or track detectors CR-39 10B radiator. measured neutron spectral anisotropy served for...
Fluorescent diamond nanoparticles (FND) have recently been introduced as promising luminescent probes for bioimaging to compete with more commonly used fluorophores and quantum dots. In this work, we investigate the formation of NV color centers in nanocrystallites using monoenergetic electrons. A large quantity (1.4 g) FNDs has irradiated cyclic relativistic electron accelerator (Microtron) surface charge up 3C/cm2 collimated accelerated electrons extracted monochromatic energies 6−25 MeV....
Nanodiamonds coated with a random cationic copolymer based on (2-dimethylaminoethyl) methacrylate (DMAEMA) and N -(2-hydroxypropyl) methacrylamide (HPMA) enable highly effective cellular delivery of siRNAs. Clathrin-mediated endocytosis is the predominant entry mechanism.
This paper deals with the design of control system for an RF cyclic electron accelerator a cavity resonator, classical type microtron. has until now been controlled manually. The is based on Mamdani-type fuzzy regulator. regulator set aid operator description and also mathematical model final optimized help genetic algorithms. normalizing denormalizing section controller shape values variables are optimized.
The ability to tailor mechanical properties and architecture is crucial in creating macroporous hydrogel scaffolds for tissue engineering. In the present work, a technique modification of pore size stiffness acrylamide-based cryogels demonstrated via regulation an electron beam irradiation dose. samples were characterized by equilibrium swelling measurements, light scanning microscopy, mercury porosimetry, Brunauer-Emmett-Teller surface area analysis, measurements. Their compared prepared...