A5014174809- Reproductive tract infections research
- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Sex work and related issues
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Cervical Cancer and HPV Research
- Pneumonia and Respiratory Infections
- Genital Health and Disease
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- HIV/AIDS Research and Interventions
- Escherichia coli research studies
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Infections and bacterial resistance
- HIV Research and Treatment
- Dermatology and Skin Diseases
- Chromium effects and bioremediation
- Advanced Photocatalysis Techniques
- Bacterial biofilms and quorum sensing
Brampton Civic Hospital
2015-2019
University of Toronto
2007-2017
Toronto Public Health
2011-2017
Public Health Ontario
2011-2017
Saskatchewan Disease Control Laboratory
2017
BC Centre for Disease Control
2017
Ulverscroft (United Kingdom)
2017
University of Alberta
2017
Provincial Laboratory of Public Health
2017
York General Hospital
2017
Myostatin, a transforming growth factor  (TGF-) family member, is potent negative regulator of skeletal muscle growth.In this study we characterized the myostatin signal transduction pathway and examined its effect on bone morphogenetic protein (BMP)-induced adipogenesis.While both BMP7 BMP2 activated transcription from BMP-responsive I-BRE-Lux reporter induced adipogenic differentiation, inhibited BMP7-but not BMP2-mediated responses.To dissect molecular mechanism antagonism, pathway.We...
Cervical human papillomavirus (HPV) infection may increase HIV risk. Since other genital infections enhance susceptibility by inducing inflammation, we assessed the impact of HPV and clearance on immunology cervico-vaginal microbiome. Genital samples were collected from 65 women for testing, immune studies microbiota assessment; repeat testing was performed after 6 months. All participants HIV-uninfected free bacterial STIs. Cytobrush-derived T cell dendritic subsets multiparameter flow...
Inorganic nanoparticles are ideal precursors for engineering barcodes rapidly detecting diseases. Despite advances in the chemical design of these barcodes, they have not advanced to clinical use because lack sensitivity and cost-effective due requirement a large read-out system. Here we combined recent quantum dot barcode technology with smartphones isothermal amplification engineer simple low-cost chip-based wireless multiplex diagnostic device. We characterized analytical performance this...
To determine whether healthy, young women in sub-Saharan Africa have a more activated immune milieu the genital tract (i.e. CD4 T cells) than similar population United States.A cross-sectional study nested phase 1 microbicide trial.Cervical cytobrushes were collected from 18 to 24-year-old San Francisco, California, USA (n = 18) and Kisumu, Kenya 36) at enrollment into trial. All participants tested negative for HIV, herpes simplex virus 2, gonorrhea, chlamydia, trichomonas, had abstained...
Background: Our aim was to determine if cervical cancer screening uptake would increase among under-screened women living in rural Ontario, Canada, at-home self-collected sampling for human papillomavirus (HPV) testing offered as a primary modality, compared invited papanicolaou (Pap) or routine opportunistic screening. Methods: Women 30–70 years of age who were overdue randomized receive (1) an HPV kit, (2) reminder invitation Pap testing, (3) standard care The first two arms also asked...
Abstract HSV-2 infection is common and generally asymptomatic, but it associated with increased HIV susceptibility disease progression. This may relate to herpes-mediated changes in genital systemic immunology. Cervical cytobrushes blood were collected from HIV-uninfected African/Caribbean women Toronto, immune cell subsets enumerated blindly by flow cytometry. Immune differences between groups assessed univariate analysis confirmed using a multivariate model. Study participants consisted of...
We conducted a comprehensive cross-sectional analysis of total and HIV-specific cervical antibody levels in HIV-1-resistant, uninfected, infected women order to examine the role responses female genital tract effect on various epidemiologic factors this population. Cervical lavages were collected from 272 subjects Pumwani commercial sex worker cohort. Total IgA IgG measured using an ELISA correlated with behavioral demographic factors. No significant difference was seen between infected,...
We evaluated a cohort of Canadian donors for T cell and antibody responses against influenza A/California/7/2009 (pH1N1) at 8-10 months after the 2nd pandemic wave by flow cytometry microneutralization assays. Memory CD8 to pH1N1 were detectable in 58% (61/105) donors. These largely due cross-reactive epitopes as, those tested, similar recall obtained A/California 2009 A/PR8 1934 H1N1 Hviruses. Longitudinal analysis single infected individual showed only small transient increase neutralizing...
Abstract We analyzed population-based surveillance data from the Toronto Invasive Bacterial Diseases Network to describe carbapenemase-producing Enterobacteriaceae (CPE) infections during 2007–2015 in south-central Ontario, Canada. reviewed patients' medical records and travel histories, microbiologic clinical characteristics of CPE infections, calculated incidence. Among 291 cases identified, New Delhi metallo-β-lactamase was predominant carbapenemase (51%). The proportion CPE-positive...
Background We designed a seroprevalence study using multiple testing assays and population sources to estimate the community of pH1N1/09 risk factors for infection before outbreak was recognized throughout pandemic end 2009/10 influenza season. Methods Residual serum specimens from five time points (between 01/2009 05/2010) samples two prospectively recruited cohort were included. The distribution explored in multivariate adjusted analyses logistic regression among cohort. Antibody levels...
Testing remnant Aptima specimens from women infected with Chlamydia trachomatis detected 13.4% (53/396) Mycoplasma genitalium compared 5.4% (22/406) in matched C. trachomatis-negative women. Overall, 9.4% (provincial ranges of 3-20%) were M. and resistance mediating mutations found 47.3% (26/55) to macrolides 1.9% (1/53) fluoroquinolones by sequencing.
Please cite this paper as: Peci et al. (2012) Community‐acquired respiratory viruses and co‐infection among patients of Ontario Sentinel practices, April 2009 to February 2010. Influenza Other Respiratory Viruses 7(4), 559–566. Background are known cocirculate but has not been described in detail during an influenza pandemic. Objectives To describe viruses, including associated attributes such as age, sex or comorbidity, presenting with influenza‐like illness a community sentinel network,...
The COVID-19 pandemic highlighted the critical need for rapid and accurate molecular diagnostic testing. Cue Point-of-Care Test (Cue POCT) is a nucleic acid amplification test (NAAT), authorized by Health Canada FDA as POCT SARS-CoV-2 detection. was deployed at network of clinics in Ontario, with
Background: The host immune response against mucosally acquired pathogens may be influenced by the mucosal milieu during acquisition. As Neisseria gonorrhoeae can impair dendritic cell and T-cell function, we hypothesized that coinfection HIV acquisition would subsequent systemic responses. Methods: Monthly screening for sexually transmitted infections was performed in high risk, seronegative Kenyan female sex workers as part of an prevention trial. Early HIV-specific CD8 responses viral...
Data on household transmission of carbapenemase-producing Enterobacterales (CPE) remain limited. We studied risk CPE co-colonization and in Ontario, Canada.
Abstract Background The spread of CPE is an increasing global threat to patient safety. We describe the introduction and evolution in south-central Ontario, Canada. Methods Toronto Invasive Bacterial Diseases Network has performed population based surveillance for metropolitan Peel region from first identified isolates 2007. All laboratories test/refer all carbapenem non-susceptible Enterobacterial PCR testing carbapenemases. Demographic medical data travel history are collected chart review...
Background: In late spring 2009, concern was raised in Canada that prior receipt of the 2008-09 trivalent inactivated influenza vaccine (TIV) associated with increased risk pandemic H1N1 (pH1N1) illness. Several epidemiologic investigations were urgently conducted through summer to assess this putative association. Methods: Studies included: (1) test-negative case-control design based on Canada's ongoing sentinel effectiveness monitoring system British Columbia, Alberta, Ontario and Quebec;...
CPE are a growing threat worldwide. Screening to identify colonization is critical control transmission in hospitals, but the sensitivity of screening different anatomic sites detect remains uncertain. We describe results by site study duration Toronto, Canada. The Toronto Invasive Bacterial Diseases Network conducts population-based surveillance Toronto/Peel Region. Consenting participants enrolled screened at enrolment, then q3mo until four consecutive negative swabs obtained. At each...
Abstract Background Though CPE in Canada are mainly acquired abroad, outbreaks/transmission Canadian hospitals have been reported. We determined the incidence of HA southern Ontario, Canada, to inform prevention and control programs. Methods Toronto Invasive Bacterial Diseases Network (TIBDN) has performed population-based surveillance for area/Peel region since were first identified October 2007. Clinical microbiology laboratories report all isolates TIBDN; annual lab audits performed....
Abstract Background Human papillomavirus type 97 (HPV97) DNA was detected in nearly 5% of anal samples collected from HIV-seropositive men living Montreal, Canada. The rate detection HPV97 the genital tract Canadian women is unknown. Whether a local epidemic Montreal also prevalence human assessed cervicovaginal cells Canada and Toronto. Findings Cervicovaginal lavages 904 (678 HIV-seropositive, 226 HIV-seronegative) 123 Toronto were tested for presence with PCR. HPV97-positive further by...