A5100337777- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Alzheimer's disease research and treatments
- Supercapacitor Materials and Fabrication
- Catalytic Processes in Materials Science
- Stress Responses and Cortisol
- Quantum Chromodynamics and Particle Interactions
- S100 Proteins and Annexins
- Salivary Gland Disorders and Functions
- Metal-Organic Frameworks: Synthesis and Applications
- Advancements in Battery Materials
- High-Energy Particle Collisions Research
- biodegradable polymer synthesis and properties
- Analytical Chemistry and Chromatography
- Pharmacological Effects of Natural Compounds
- Textile materials and evaluations
- Dementia and Cognitive Impairment Research
- Catalysis and Oxidation Reactions
- Magnolia and Illicium research
- Particle physics theoretical and experimental studies
- Health, Environment, Cognitive Aging
- Microplastics and Plastic Pollution
- Nanomaterials for catalytic reactions
- Covalent Organic Framework Applications
Fuzhou University
2024-2025
Columbia University Irving Medical Center
2023-2025
Guangxi Academy of Sciences
2022-2025
Chongqing Public Health Medical Center
2023-2024
Chinese Academy of Sciences
2024
Changchun Institute of Applied Chemistry
2024
University of Science and Technology of China
2024
State Key Laboratory of Polymer Physics and Chemistry
2024
Shandong University
2023
Second Affiliated Hospital of Jilin University
2023
Abstract Prolonged exposure to glucocorticoids, the main stress hormones, damages brain and is a risk factor for depression Alzheimer's disease. Two major drivers of glucocorticoid-related neurotoxicity are mitochondrial dysfunction Tau pathology; however, molecular/cellular mechanisms precipitating these events, their causal relationship, remain unclear. Using cultured murine hippocampal neurons 4–5-month-old mice treated with synthetic glucocorticoid dexamethasone, we investigate...
Lipoic acid (LA) is a versatile antioxidant that has been used in the treatment of various oxidation-reduction diseases over past 70 years. Owing to its large five-membered ring tension, dynamic disulfide bond LA highly active, enabling formation poly(lipoic acid) (PLA) via ring-opening polymerization (ROP). Herein, we first summarize disulfide-mediated ROP strategies, providing basic routes for designing and preparing PLA-based materials. PLA, as biologically derived, low toxic, easily...
Micropterus salmoides rhabdovirus (MSRV) is a primary viral pathogen in largemouth bass aquaculture, which leads to tremendous economic losses yearly. Currently, there are no approved drugs for the treatment and control of this virus. Our previous studies screened herb Magnolia officinalis from many traditional Chinese medicines, we isolated identified magnolol as its main active compound against multiple rhabdoviruses, including MSRV. On basis structure–activity relationship pharmacophore...
Abstract APOE4 is the leading genetic risk factor for Alzheimer’s disease, and chronic stress a environmental factor. Studies suggest that confers vulnerability to behavioral neuropathological effects of stress, representing potential mechanism by which this variant accelerates onset progression. Whether how -mediated manifests in neurons hippocampus, brain region particularly susceptible pathology, remains unexplored. Using combination vivo vitro experiments humanized APOE3 knockin mice...
Aquaculture is a rapidly growing sector of global food production, playing vital role in poverty alleviation, security, and income generation. However, it faces substantial challenges, particularly due to infections caused by the protozoan Ichthyophthirius multifiliis, leading reduced yields economic losses. In this study, two classes magnolol derivatives (M1-M26) were synthesized evaluated for their parasiticidal activity against I. multifiliis theronts tomonts. Based on determined EC50...
Enterocytozoon hepatopenaei (EHP) is the pathogen of hepatopancreatic microsporidiosis (HPM) in shrimp. The diseased shrimp Litopenaeus vannamei exhibits a slow growth syndrome, which causes severe economic losses. Herein, 4D label-free quantitative proteomics was employed to analyze hepatopancreas L. with light (EHPptp2 < 103 copies/50 ng hpDNA, L group) and heavy > 104 H load EHP better understand pathogenesis HPM. Exactly 786 (L 1056 (H differentially expressed proteins (DEPs) versus...
TGF-β1 (Transforming growth factor-β1) plays an important role in the regeneration and repair of pulp-dentin complex. However, biological function on odontoblastic differentiation remains unclear, mainly due to processes were controlled by complex signaling pathways. This study aimed investigate pathways involved regulating early dental pulp stem cells (DPSCs) their functional role. DPSCs treated with 1 ng/mL Western blotting was conducted examine activation protein kinase B (AKT), small...
Developing underwater stable and durable hydrogel coatings with drag-reducing, drug release, antibacterial properties is essential for lots of biomedical applications. However, most cannot meet the requirement stability versatility, which severely limits their widespread use. In this work, an stable, substrate-independent gelatin composite (GMP) coating developed through covalent crosslinks, where a silane coupling agent unsaturated double bond grafted onto substrate co-deposited...
Abstract Background Empyema caused by Streptococcus constellatus (S. constellatus) is rare in patients with HIV. To analyze the clinical data of a patient living HIV (PLHIV), who got empyema S. constellatus, investigating diagnosis and treatment this disease through literature review to improve understanding disease. Case presentation We have reported here 58-year-old male PLHIV cough, wheezing, fever for 20 days. He has history type 2 diabetes, alcohol abuse, teeth extracted. Chest computed...
Abstract Chronic stress and elevated levels of glucocorticoids (GCs), the main hormones, accelerate Alzheimer’s disease (AD) onset progression. A major driver AD progression is spreading pathogenic Tau protein between brain regions, precipitated by neuronal secretion. While high GC are known to induce intraneuronal pathology ( i.e . hyperphosphorylation, oligomerization) in animal models, their role trans-neuronal unexplored. Here, we find that GCs promote secretion full-length, primarily...
Computer-aided detection, used in the screening and diagnosing of cognitive impairment, provides an objective, valid, convenient assessment. Particularly, digital sensor technology is a promising detection method.This study aimed to develop validate novel Trail Making Test (TMT) using combination paper electronic devices.This included community-dwelling older adult individuals (n=297), who were classified into (1) cognitively healthy controls (HC; n=100 participants), (2) participants...
The mean platelet volume-to-lymphocyte ratio (MPVLR), as a novel marker of thrombosis and inflammation, has been demonstrated to be closely linked poor cardiovascular disease prognosis. However, the correlation between MPVLR acute ischemic stroke (AIS) remains unclear. This study, therefore, aimed clarify relationship short-term prognosis AIS.A total 315 patients with first-time AIS diagnoses were recruited divided into 3 groups based on tri-sectional quantiles for admission: group 1 (N =...
Summary Over the past few years, growing market demand for functional food leads to development of inulin‐containing staple food. Comparing previous works, this study investigates effect inulin with different polymerisation degrees on dough rheology and water distribution in fresh noodles. Rheological properties gluten, either using empirical or fundamental methods illustrate distinctly improved farinograph properties. The tensile noodles added LCI increased. Both SCI reduced gelatinisation...
Purpose: Distal-type cervical spondylotic amyotrophy (CSA) is an uncommon syndrome associated with spondylosis. The pathogenic mechanism of distal-type CSA still unclear. aim the current study was to analyze central motor conduction time (CMCT) in cases and investigate role cord compressive injury CSA. Methods: Both 28 21 healthy subjects accepted CMCT measures, unit number estimation, handgrip strength examination, magnetic resonance imaging evaluation. Results: In this study, nine (9/28,...
Ambipolar organic phototransistors (OPTs) operating in the near-infrared II (NIR-II) were successfully fabricated by using an planar-heterojunction channel layer and organic–inorganic charge-transfer-complex (CTC) photosensitive layer. After optimizations of ratio vanadium pentoxide CTC hybrid system substrate temperature deposited layer, devices shows most balanced output characteristics dark under 1310 nm light illumination. These OPTs yielded significantly enhanced currents upon infrared...
Cisplatin (DDP) is a first-line chemotherapeutic drug against lung cancer. Nonetheless, the effectiveness of this hampered by resistance. Overcoming resistance crucial for improving outcomes cancer treatment. Here, we reported effect CX-23, an activated triptolide analogue that targets NAD (P)H quinone dehydrogenase 1 (NQO1), on DDP-resistant and sensitizes to chemotherapy. Our findings unveiled antiproliferative activity CX-23 both A549- A549 (A549/DDP) cells while enhancing...