A5074064134- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vasculitis and related conditions
- Blood disorders and treatments
- Mast cells and histamine
- Mycobacterium research and diagnosis
- Ocular Infections and Treatments
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Corneal Surgery and Treatments
- Photodynamic Therapy Research Studies
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Antifungal resistance and susceptibility
- Nanoplatforms for cancer theranostics
- Inflammasome and immune disorders
- Ocular Surface and Contact Lens
- Acute Ischemic Stroke Management
- Blood donation and transfusion practices
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Blood transfusion and management
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
University of Veterinary Medicine Hannover, Foundation
2019-2024
Centre for Inflammation Research
2024
University of Edinburgh
2024
University Hospital Bonn
2014
The emergence of multidrug resistant (MDR) pathogens and the scarcity new potent antibiotics antifungals are one biggest threats to human health. Antimicrobial photodynamic therapy (aPDT) combines light photosensitizers kill drug-resistant pathogens; however, there limited materials that can effectively ablate different classes infective pathogens. In present work, a class benzodiazole-paired is designed as highly PDT agents with broad-spectrum antimicrobial activity upon illumination...
Lenalidomide activates the immune system, but exact immunomodulatory mechanisms of lenalidomide in vivo are poorly defined. In an observational study we assessed impact on different populations cells multiple myeloma patients. therapy was associated with increased amounts a CD8(+) T cell subset, phenotypically staged between classical central memory (TCM) and effector (TEM), consequently termed TCM/TEM. The moderate expression perforin/granzyme phenotypical profile these identifies them as...
Equine recurrent uveitis (ERU) is considered one of the most important eye diseases in horses and typically appears with relapsing inflammatory episodes without systemic effects. Various disorders have been described as an initial trigger, including infections. Independent initiating cause, there are numerous indications that ERU immune-mediated disease. We investigated whether neutrophil extracellular traps (NETs) part pathogenesis. Therefore, vitreous body fluids (VBF), sera, histological...
Neutrophils are important effector cells of the innate immune system, traditionally regarded to have a short life span. The goal this study was evaluate effect whole blood storage on neutrophil functions, e.g., viability, antimicrobial effect, extracellular trap (NET) formation and phagocytosis. Therefore, fresh porcine compared stored for 24 h in dark at room temperature. Different cell parameters isolated neutrophils were analyzed. following analyzed: count, band segmented cholesterol...
During the COVID-19 pandemic, vaccination is most important countermeasure. Pharmacovigilance concerns however emerged with very rare, but potentially disastrous thrombotic complications following ChAdOx1. Platelet factor-4 antibody mediated vaccine-induced immune thrombocytopenia (VITT) was described as an underlying mechanism of these events. Recent work moreover suggests that mechanisms immunothrombosis including neutrophil extracellular trap (NET) formation might be critical for...
Equine recurrent uveitis (ERU) is a common ocular disease of horses and described as model for human autoimmune uveitis. This immune-mediated, inflammatory condition progressively destroys the eye, ultimately leading to blindness. Genetic factors, next infections with Leptospira, are discussed key factors in pathogenesis. Furthermore, release neutrophil extracellular traps (NETs) by activated neutrophils involved. NETs composed decondensed chromatin proteins that can immobilize invading...
Abstract Inflammation including immunothrombosis by neutrophil extracellular traps (NETs) has important implications in acute ischemic stroke and can affect reperfusion status, susceptibility to associated infections (SAI) as well functional clinical outcome. NETs were shown be prevalent thrombi NET markers found patients’ blood. However, little is known whether blood derived reflect the amount of thrombi. Conclusions from thrombus composition might open avenues for novel strategies...
Formation of neutrophil extracellular traps was first described in 2004, showing that NETs are composed decondensed chromatin fibers and nuclear granule components. Free DNA is often used to quantify NETs, but differentiate NETosis from necrotic DNA-release, immunofluorescence microscopy with NET-specific markers required. Although evaluation by hand time-consuming difficult standardize, it still widespread. Unfortunately, no standardized method only limited software tools available for NET...