A5111940653- Antifungal resistance and susceptibility
- Gut microbiota and health
- Fungal Infections and Studies
- Digestive system and related health
- Nail Diseases and Treatments
- Fungal Biology and Applications
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Celiac Disease Research and Management
- Ear Surgery and Otitis Media
- Yeasts and Rust Fungi Studies
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Medical and Biological Ozone Research
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Respiratory and Cough-Related Research
- Viral Infections and Vectors
- Nosocomial Infections in ICU
- Gastroesophageal reflux and treatments
- Autopsy Techniques and Outcomes
- Plant Pathogens and Fungal Diseases
- Neonatal Health and Biochemistry
Seattle Pacific University
2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2019-2021
Universität Greifswald
2000-2011
University of Göttingen
2011
TU Dresden
2010
Universitätsmedizin Greifswald
1981-2004
Robert Bosch Hospital
1999
Institut für Hygiene und Umwelt
1993
University of El Salvador
1979-1983
Ministerio de Ganadería Agricultura y Pesca
1979
Cardiac remodelling might be an important mechanism for aldosterone-mediated cardiovascular (CV) morbidity and mortality. Previous studies relating aldosterone to left ventricular (LV) structure however revealed conflicting results. We aimed evaluate the relationship of serum concentration (SAC) aldosterone-to-renin ratio (ARR) with echocardiographic parameters LV in CV risk patients preserved ejection fraction (LVEF). studied 1575 participants (54.1% female) factors LVEF >50% (61.7 ± 6.1%)....
There are two aspects about the presence of Candida in human orointestinal tract: (i) it is a part normal flora and (ii) risk factor for immunocompromised patients. The tract can be considered reservoir species, several which from oral cavity, stomach, duodenal juice faeces. Their germ counts small large bowel do not exceed 10(4) cfu/ml resp.g. input to well-developed faecal system under continuous flow culture conditions did lead multiplication yeast. take into diminish counts. If, however,...
We analysed the autopsy records of Greifswald University Institute Pathology (located in Eastern Germany) respect findings candidosis and aspergillosis from 1994 to 2003. also present eight immature aborted fetuses premature infants with a mycosis. In total 2027 autopsies we found 164 cases invasive (8.1%) including combination both on four occasions. Other authors cited between 0.7 7.3%. these 10 years our material mycoses particular increased spite slightly decreased numbers autopsies. The...
Summary. Medico‐mycological investigations began at Greifswald in Germany as early 1842 when Wilhelm Baum (1799–1883) was appointed to the chair of surgery university. This is shown by some theses time, well discovery contagious nature pityriasis versicolor Carl Ferdinand Eichstedt (1816‐92), who identified a fungus cause (1846), later named Microsporon furfur (C. Robin 1853). In 1868 physician Karl Friedrich Mosler (1831–1911) published clinical‐mycological studies and about animal feeding...
Long-term continuous flow culture allows the investigation of dynamic biofilms under microaerophilic or aerobic conditions. We studied biofilm formation and changes susceptibility in 30 blood isolates (48 experiments) different Candida species exposed to anidulafungin 0.16 ml 7.7 chambers. The rate (F) was adjusted a very low 1.3 h−1 resulting an exchange up 180 6.25 times chamber volumes per 24 hours small large chambers, respectively. results at were markedly from cultures micro well...
In an evaluation of 2537 endoscopic investigations the upper digestive tract, yeast-like fungi were found in cultures from 53 purposive brushings (2.1 %) obtained visible mycotic areas. 46 cases esophagus only was affected. stomach and surrounding anastomosis after resection, we 6 positive results. Once, findings seen as well stomach. Determination revealed Candida albicans 43 cases. Other cultured 18 times, among them Torulopsis glabrata 3 times. every mycosis culture it is useful to...
Salmon is the most commonly consumed finfish in United States of America (USA), and mislabeling salmon a widespread problem. Washington State global supplier wild-caught Pacific local results substantial economic, ecological, cultural impacts. Previous studies identified high levels mislabeled both markets restaurants, resulting legislation being passed that requires proper labeling products, including identifying it as or farm-raised. To investigate whether recent legislative efforts...
Summary In November 1839 the young university lecturer Bernhard (von) Langenbeck (1810–1887) published first description of a fungus as aetiological agent an oro‐pharyngeal and oesophageal candidosis. We present his in English translated paper entitled ‘Finding fungi on mucous membrane gullet typhoid fever corpse’ (Germ.) ‘ Neue Notizen aus dem Gebiete der Natur‐ und Heilkunde ’ (Froriep). There are interesting particulars Langenbeck's discussion. The publication happened at same time that...
Summary. We used the model of faecal microflora under continuous flow culture (CFC) conditions to study growth Candida albicans in mixed cultures. The development is usually limited by high germ counts aerobic and anaerobic bacteria. flora could be obtained neither inflow C. CFC monocultures nor intermittent input highly concentrated suspensions into system. If system was run observed. After some days, however, again suppressed further yeasts. Only marked destruction antibiotics resulted or...
In the period 1992-95 there was a significant shift in spectrum of Candida species University Hospital Greifswald. During this time, annual number specimens taken for mycological investigations adults increased threefold (total n = 11,568). The isolation rate 50.5%. percentage C. albicans isolates decreased from 76% to 54.4% with lowest level 1994. opposite trend occurrence non-C. seen, example glabrata, 11.7% 28.4%. We found only 98 strains parapsilosis (1.4%) during 4 years. variety...
Zusammenfassung Pathologische Keimzahlen im Duodenum treten häufiger bei einer mangelhaften oder fehlenden Magensäuresekretion auf. Im Gegensatz zu den Bakterien findet sich für die Hefen eine etwa gleichgroße Häufigkeit höhere in allen drei geprüften Gruppen mit unterschiedlicher Magenazidität. Statistisch sichere Unterschiede einzelnen Hefearten lassen nicht nachweisen. Auffällig ist das gehäufte Vorkommen von Torμlopsis glabrata und Candida tropicalis normaziden Magensäften. Nach...
Zusammenfassung Duodenalsondierungen bei 303 Patienten mit verschiedenen gastrointestinalen Erkrankungen und 26 Kontrollpersonen erlauben folgende Schlußfolgerungen: Hefepilze lassen sich in beiden Gruppen etwa einem Drittel der Fälle nach‐weisen. Höhere Keimzahlen fanden wir nur Erkrankungen. Eine Häufung läßt Leberzirrhose den Dünndarmdivertikeln feststellen. Die Hefekeimzahlen liegen Regel unter denen Bakterien. Hefen werden seltener geringerer Menge aus Duodenalsaflfraktionen nach...
We used the model of continuous flow culture (cfc) to study growth Candida species. This allows special test conditions: a long generation time 15-20 hs, controlled limitation nitrogen sources and carbohydrates, comparison under aerobic anaerobic conditions simultaneously. These were effect antimycotic drugs, mainly during 7 10 days. Germ tube formation as virulence factor was more abundant faster in cfc strains with stronger adherence buccal epithelium cells. Co-cultivation C. albicans...
Summary. We investigated the influence of voriconazole and fluconazole in a long term trial continuous flow culture (cfc) up to 9 days. The effects these azoles were different dependence on growth circumstances. Under anaerobic conditions fungicidal effect was detectable, defined by an inhibition 99.9%. This also applied for majority tested strains C. albicans. aerobic with otherwise similar situation we found only fungistatic reaction (inhibition 90%). Fluorescence microscopy comparing...
The aim was the investigation of fungal colonization and morphological alterations under influence voriconazole in an vitro system. Voriconazole stopped growth Candida albicans (wild type SC5314) on cover slips microtiter plates dependent drug concentration, time before input oxygen concentration. direct microscopy by fluorescence staining with optical brightener Blancophor showed short bizarrely deformed mycelia looking swollen. glass diminished. Microcolonies or starting biofilm formation...
Reconstituted multilayered oesophageal epithelium appears to be a good basis test the efficacy of voriconazole (VOR) and fluconazole (FLU) in tissue. The resulting model Candida oesophagitis was approaching vivo situation. We infected tissue with 2 x 10(6) cfu albicans strain SC5314. In trials FLU we also used clinical strains. Four hours after infection growth C. appeared mainly hyphae on surface tendency invasion. destruction began 36 h. VOR (2 16 microg ml-1, respectively) prevented...
Funguria, indirect anti‐ Candida haemagglutination test (C‐IHT) and ‐specific immunoglobulins C‐IgM, C‐IgG C‐IgA were investigated under suspicion of systemic candidosis in critically ill patients. A total 143 urine cultures studied for from 74 adults a median count log 3.0 CFU ml −1 was found. Most isolated species albicans glabrata . In 14 cases candidaemia there no regular agreement between the finding blood urine. with candiduria ≥log stronger increase C‐IHT titres all three after 5–7...