A5104106183- Antimicrobial Peptides and Activities
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Adsorption and biosorption for pollutant removal
- Bacterial biofilms and quorum sensing
- Cholinesterase and Neurodegenerative Diseases
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Water Quality Monitoring and Analysis
- Plant nutrient uptake and metabolism
- Venomous Animal Envenomation and Studies
- Nanoparticles: synthesis and applications
- Entomopathogenic Microorganisms in Pest Control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Oral microbiology and periodontitis research
- Polysaccharides and Plant Cell Walls
- Synthesis and Biological Evaluation
- Nonlinear Optical Materials Research
- Insect symbiosis and bacterial influences
- Dye analysis and toxicity
- Antifungal resistance and susceptibility
- Synthesis and biological activity
- Carbohydrate Chemistry and Synthesis
- Computational Drug Discovery Methods
- Antimicrobial agents and applications
Universidade Federal do Ceará
2009-2025
Background: The rise of multidrug-resistant (MDR) bacteria poses a significant challenge to global public health, contributing increased morbidity and mortality rates. In this context, the repurposing existing drugs has emerged as promising strategy. study, hydralazine (HDZ), vasodilator used an antihypertensive since 1952, demonstrated antibacterial antibiofilm activity against both Gram-positive Gram-negative bacteria. Methods: (HDZ) was evaluated strains through minimum inhibitory...
Histoplasmosis is a respiratory disease caused by Histoplasma capsulatum, dimorphic fungus, with high mortality and morbidity rates, especially in immunocompromised patients. Considering the small existing therapeutic arsenal, new treatment approaches are still required. Chitosan, linear polysaccharide obtained from partial chitin deacetylation, has anti-inflammatory, antimicrobial, biocompatibility, biodegradability, non-toxicity properties. Chitosan different deacetylation degrees...
In this study, five types of "Juá" bark (Ziziphus joazeiro) were investigated for the removal Zn(II) ions from aqueous solutions. The tested samples natural barks, powder, washed with water (WW), ethanol at 80 % (EE), and 0.5 N NaOH. adsorptive tests kinetics, equilibrium isotherms, thermodynamics, desorption. WW adsorbent presented better adsorption metal confirmed by scanning electronic microscopy dispersive spectroscopy (SEM-EDS). After reaching time, all adsorbents, except NaOH, a...
Trypanosoma cruzi, the etiological agent of Chagas disease, is responsible for infection millions people worldwide and it a public health problem, without an effective cure. Four fragments with antimicrobial potential from hemocyanin Penaeus monodon shrimp were identified using computer software AMPA. The present study aimed to evaluate antichagasic effect these four peptides (Hmc364-382, Hmc666-678, Hmc185-197 Hmc476-498). tested against epimastigote, trypomastigote amastigote forms cruzi Y...
This study aimed to evaluate the effect of proteinase K on mature biofilms dermatophytes, by assays metabolic activity and biomass. In addition, K–terbinafine K–griseofulvin interactions against these were investigated checkerboard assay scanning electron confocal microscopy. The exposed 32 µg ml−1 had lower biomass, 39% 38%, respectively. Drug synergistic, with reducing minimum inhibitory concentration antifungals dermatophyte at a combined 128–256 terbinafine griseofulvin. Microscopic...
Oral candidiasis is a common fungal infection that affects the oral mucosa, and happens when Candida albicans interacts with bacteria in microbiota, such as Streptococcus mutans, causing severe early childhood caries. C. S. mutans mixed biofilms are challenging to treat conventional antimicrobial therapies, thus, new anti-infective drugs required. This study aimed test drug delivery system based on chitosan microparticles loaded geranium lemongrass essential oils inhibit biofilms.Chitosan...
Abstract In this study, four types of “Juá” stem barks ( Ziziphus joazeiro ) were investigated for the removal Cu(II) from aqueous solutions. The tested samples included natural coarse barks, and washed with water, ethanol–water, NaOH solvent-modified materials simulated waste industrial extraction saponins bark. valorization these processing residues as sorbents was evaluated. NaOH-washed sorbent exhibited highest sorption capacity (maximum $$\approx$$ <mml:math...
Abstract Chagas disease, caused by the protozoan parasite Trypanosoma cruzi and transmitted mainly triatomine insects, represents a significant challenge to public health, especially in impoverished regions. Current treatments, such as benznidazole nifurtimox, have limitations, including serious side effects reduced efficacy chronic phase. This work aims evaluate antitrypanosomal activity of ursolic acid‐derived chalcones (UACD) using ligand‐based virtual screening approach. To this end,...
Abstract The present study aimed to evaluate the removal efficiency of two types cationic dyes different classes – methylene blue (MB) and malachite green (MG) from a synthetic effluent using calcium surfactant (CaSF) originated used frying soybean oil. Fourier Transform Infrared Spectroscopy (FTIR) spectra showed that functional groups on surface CaSF can form complexes or bonds with dye molecules and, consequently, promote their adsorption. adsorption kinetics studies indicated equilibrium...