A5049851936- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- ATP Synthase and ATPases Research
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Complement system in diseases
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Lipoproteins and Cardiovascular Health
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Calcium signaling and nucleotide metabolism
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Cellular transport and secretion
- Ion Transport and Channel Regulation
- Photosynthetic Processes and Mechanisms
- Aortic Disease and Treatment Approaches
- Renal and related cancers
- Ion Channels and Receptors
- Kawasaki Disease and Coronary Complications
- Trauma Management and Diagnosis
Kokura Memorial Hospital
2022-2024
Kagoshima University
2018-2024
Himeji Dokkyo University
2018-2023
Kyoto University
2002-2023
Doshisha Women's College of Liberal Arts
2005-2021
Izumi City General Hospital
2017-2018
BioChem Technology (United States)
2017
Gunma University
1990-1992
The nascent phagosome progressively establishes an acidic milieu by acquiring a proton pump, the vacuolar-type ATPase (V-ATPase). However, origin of phagosomal V-ATPase remains poorly understood. We found that phagosomes were enriched with a3 subunit, which also accumulated in late endosomes and lysosomes. modified mouse Tcirg1 locus encoding subunit a3, to express a3-GFP fusion protein. Live-cell imaging immunofluorescence microscopy revealed received from tubular structures extending...
Abstract The objective of the study is to investigate difference in 1-year late lumen loss (LLL) between high- (IN.PACT Admiral) and low-dose (Lutonix) paclitaxel-coated balloon (PCB). Although a recent randomized clinical trial demonstrated no efficacy endpoint PCB, it remains unclear whether high-dose PCB was superior actual practice. We enrolled 64 patients with 67 de novo femoropopliteal lesions who underwent angioplasty at Kokura Memorial Hospital from May 2014 March 2020 subsequent...
Background The usefulness of preprocedural nutritional status to stratify prognosis after transcatheter aortic valve implantation has been evaluated; however, the studies conducted so far have relatively small and/or focused on a single index. This study sought assess prevalence and prognostic impact malnutrition in patients with severe stenosis undergoing implantation. Methods Results We applied Controlling Nutritional Status score, Geriatric Risk Index, Prognostic Index 1040 consecutive...
Background Vacuolar-type proton transporting ATPase (V-ATPase) is involved in the proper development of visual function. Mutations Tcirg1 (also known as Atp6V0a3) locus, which encodes a3 subunit V-ATPase, cause severe autosomal recessive osteopetrosis (ARO) humans. ARO often associated with impaired vision most likely because nerve compression at optic canal. We examined ocular phenotype mice deficient Methodology/Principal Findings X-ray microtomography showed narrowed foramina skull,...
Abstract There were no data comparing the in-hospital outcomes after transcatheter aortic valve implantation (TAVI) with those surgical replacement (SAVR) in Japan. Among consecutive patients severe AS between April 2018 and December 2020 CURRENT Registry-2, we identified 1714 who underwent (TAVI group: 1134 patients, SAVR 580 patients). Patients TAVI group much older (84.4 versus 73.6 years, P < 0.001) more often had comorbidities than group. In-hospital death rate was numerically lower...
In the Asian cohort, data are limited on risk for coronary obstruction due to sinus of Valsalva (SOV) sequestration in redo transcatheter aortic valve replacement (TAVR) procedures.
A high permanent pacemaker implantation (PPI) risk remains a concern of self-expandable transcatheter aortic valve implantation, despite the continued improvements in methodology. We aimed to assess impact real-time direct visualization membranous septum using transjugular intracardiac echocardiography (ICE) during on reducing rates conduction disturbances including need for PPI.
Abstract Aims A considerable proportion of candidates for transcatheter aortic valve implantation (TAVI) have underlying heart failure (HF) with preserved ejection fraction (HFpEF), which can be challenging diagnosis because significant valvular disease should excluded before diagnosing HFpEF. This study investigated the long‐term prognostic value pre‐procedural H 2 FPEF score in patients (EF) undergoing TAVI. Methods and results Patients who underwent TAVI between October 2013 May 2017 were...
Background: Data on concomitant mitral regurgitation (MR) in patients with severe aortic stenosis (AS) are scarce.
The vacuolar-type proton pump ATPase (V-ATPase) plays several pivotal roles in the acidification of diverse intracellular compartments and extracellular environment. a subunit isoforms a1, a2, a3, constituting membrane-embedded section, are expressed various tissues, they involved regulation subcellular localization activity holocomplex. Therefore, characterization their properties is indispensable for dissection physiological V-ATPase highly differentiated cells. In this study, we report...
To assess the structural requirements for Gs coupling by prostaglandin E receptors (EPs), Gs-coupled EP2 and Gi-coupled EP3β were used to generate hybrid receptors. Interchanging of whole i2 loop its N-terminal half (i2N) had no effect on binding both expressed in HEK293 cells. Agonist-induced cAMP formation was observed wild type but not loop- or i2N-substituted EP2. Wild left levels unaffected, whereas EP3 gained agonist-induced adenylyl cyclase stimulation. In EP2, ability stimulate lost...
There is scarce data evaluating the current practice pattern and clinical outcomes for patients with severe aortic stenosis (AS), including both those who underwent surgical valve replacement (SAVR) or transcatheter implantation (TAVI) were managed conservatively in TAVI era.
Effective phagocytosis is crucial for host defense against pathogens. Macrophages entrap pathogens into a phagosome and subsequently acidic lysosomes fuse to the phagosome. Previous studies showed pivotal role of actin-remodeling mediated by phosphoinositide-related signaling in formation, but mechanisms phagosome-lysosome fusion remain unexplored. Here we show that complement-mediated phagocytosis, requires disappearance F-actin structure surrounding tyrosine kinase Syk plays key this...
A 41-year-old female had atopic dermatitis-like skin lesions since the age of 21, and for past 6 years many tumors developed on body, lower extremities other areas. The histological picture tumor, eosinophilia high IgE in peripheral blood were consistent with a diagnosis Kimura's disease. Although markedly reduced by oral prednisolone administration, thereafter papules appeared disseminated over body swelling superficial lymph nodes. Immunohistochemical examination indicated marked...