A5041986322- Solid-state spectroscopy and crystallography
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Advanced NMR Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Electron Spin Resonance Studies
- Mast cells and histamine
- Urticaria and Related Conditions
- Spectroscopy and Quantum Chemical Studies
- Medical Imaging and Analysis
- Physics of Superconductivity and Magnetism
- Nitric Oxide and Endothelin Effects
- Musculoskeletal pain and rehabilitation
- Particle physics theoretical and experimental studies
- Protein Kinase Regulation and GTPase Signaling
- Free Radicals and Antioxidants
- Advanced Condensed Matter Physics
- Drug-Induced Adverse Reactions
- Magnetic properties of thin films
- Estrogen and related hormone effects
- Cancer therapeutics and mechanisms
- Quantum Chromodynamics and Particle Interactions
- Food Allergy and Anaphylaxis Research
- Biochemical Analysis and Sensing Techniques
- Bioactive Compounds and Antitumor Agents
Kyushu University
2022-2024
Life Science Institute
2022
Kyoto University
2009-2022
Graduate School USA
2018
Ōtani University
2014
Kumamoto University
1974-2013
Kyoto Pharmaceutical University
2009-2013
Nippon Medical School
2004
Hiroshima University
1981-1989
Institute of High Energy Physics
1982-1983
Spin-dependent asymmetries have been measured in inclusive deep-inelastic scattering of longitudinally polarized electrons by protons. Data were obtained at a angle 10\ifmmode^\circ\else\textdegree\fi{} and for incident energies 16.2 22.7 GeV, which cover the kinematic range $0.18<x<0.70$ $3.5<{Q}^{2}<10.0$ (${\mathrm{G}\mathrm{e}\mathrm{V}/\mathit{c})}^{2}$. The present results provide test scaling Bjorken Ellis-Jaffe sum rules are compared with various models proton spin structure.
Abstract Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, organ-specific regulation mechanism poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), terminal enzyme cholesterol biosynthesis, as a regulator hepatocytes. Genetic and pharmacological inhibition (with AY9944) DHCR7 suppress human hepatocellular carcinoma Huh-7 cells. increases its substrate, (7-DHC). Furthermore, exogenous 7-DHC supplementation...
PGE2 has long been known as a potentiator of acute inflammation, but its mechanisms action still remain to be defined. In this study, we employed inflammatory swelling induced in mice by arachidonate and models dissected the role each EP receptor at molecular level. Arachidonate- or PGE2-induced vascular permeability was significantly reduced EP3-deficient mice. Intriguingly, response suppressed histamine H1 antagonist treatment, histidine decarboxylase deficiency, mast cell deficiency. The...
The prostaglandin (PG) receptors EP4 and FP have the potential to exert negative effects on adipogenesis, but exact contribution of endogenous PG-driven receptor signaling this process is not fully understood. In study, we employed an adipocyte differentiation system from mouse embryonic fibroblasts (MEF) compared each PG receptor-deficiency differentiation. wild-type (WT) MEF cells, inhibition synthesis by indomethacin augmented differentiation, whereas exogenous PGE2, as well agonist,...
G protein-coupled receptors (GPCRs), which are indispensable to life and also implicated in a number of diseases, construct important drug targets. For the efficient structure-guided design, however, their structural stabilities must be enhanced. An amino-acid mutation is known possibly lead enhancement, but currently available experimental theoretical methods for identifying stabilizing mutations suffer such drawbacks as incapability exploring whole mutational space with minor effort...
Prostaglandin receptors have been implicated in a wide range of functions, including inflammation, immune response, reproduction, and cancer. Our group has previously determined the crystal structure active-like EP3 bound to its endogenous agonist, prostaglandin E2. Here, we present single-particle cryoelectron microscopy (cryo-EM) human EP3-Gi signaling complex at resolution 3.4 Å. The reveals binding mode Gi structural changes induced by binding. In addition, compare with other subtypes...
Cumulus cells surround the oocyte and regulate production assembly of extracellular matrix (ECM) around cumulus-oocyte complex for its timely interaction with sperm in oviduct. We recently found that C-C chemokines such as CCL2, CCL7, CCL9 are produced stimulate integrin-mediated ECM postovulatory cumulus to protect eggs prostaglandin E2-EP2 signaling facilitates fertilization by suppressing this chemokine signaling, which otherwise results failure preventing penetration through ECM....
Recent studies have highlighted the indispensable role of oxidized lipids in inflammatory responses, cell death, and disease pathogenesis. Consequently, inhibitors targeting lipids, particularly lipid-derived radicals critical lipid peroxidation, which are known as radical-trapping antioxidants (RTAs), been actively pursued. We focused our investigation on nitroxide compounds that rapid second-order reaction rate constants for with radicals. A novel screening system was developed by...
Various multisubstituted benzothiophenes, including those with various heteroatom substituents and EP4 antagonist analogs, have been prepared easily <italic>via</italic> 6,7-thienobenzynes generated from <italic>o</italic>-silylaryl triflate-type precursors.
Recently, mitochondrial dysfunction has gained attention as a causative factor in the pathogenesis and progression of age-related macular degeneration (AMD). Mitochondrial damage plays key role metabolism disrupts balance intracellular metabolic pathways, such oxidative phosphorylation (OXPHOS) glycolysis. In this study, we focused on oxidized low-density lipoprotein (ox-LDL), major constituent drusen that accumulates retina patients with AMD, investigated whether it could be for alterations...
Summary In the present study, authors administered 100 mg itraconazole (ITCZ) twice daily for a period of 1 week to six patients with hyperkeratotic type tinea pedis, and examined its efficacy, safety profile, usefulness. ITCZ concentration in stratum corneum was also measured examine mobility drug into affected site planta pedis. part first detected at after completion administration, gradually increased over time, peaked 3 weeks, sum hydroxyitraconazole (OH‐ITCZ) amounting 163.7 ng g −1 on...