A5065550522- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Virus-based gene therapy research
- Aortic aneurysm repair treatments
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Effects of Exercise
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Vascular Anomalies and Treatments
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Conditions and Treatments
- Cardiovascular Disease and Adiposity
- Renal and Vascular Pathologies
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Central Venous Catheters and Hemodialysis
- Bone Tumor Diagnosis and Treatments
Istituto Clinico Sant'Ambrogio
2014-2022
University of Parma
2022
Fondazione Toscana Gabriele Monasterio
2009-2015
Nieuwegein Fonds
2015
Institut des Arts de Diffusion
2015
Analysis Group (United States)
2015
Humanitas University
2014
Roche (Switzerland)
2014
Regione Toscana
2012
New York Medical College
2006
After a panel process, recommendations on the use of sutureless and rapid deployment valves in aortic valve replacement were given with special respect as an alternative to stented valves. Thirty-one international experts both sutureless, bioprostheses constituted panel. thorough literature review, evidence-based rated three-step modified Delphi approach by experts. Literature research could identify 67 clinical trials, 4 guidelines 10 systematic reviews for detailed text analysis obtain...
To report early and long-term outcomes of patients undergoing minimally invasive mitral valve surgery (MIMVS) through right mini-thoracotomy (RT) over a 10-year period. From September 2003 to December 2013, total 1604 consecutive underwent MIMVS RT. The mean age was 63 ± 13 years, 770 (48 %) were female 218 (13.6 had previous cardiac operations. most predominant pathology degenerative disease (70 %), followed by functional regurgitation (12 rheumatic (9.4 endocarditis (5 prosthetic...
We have previously shown that VEGF165 gene delivery into ischemic skeletal muscle exerts not only proangiogenic, but also remarkable antiapoptotic and proregenerative activity. The aim of this study was to determine whether recombinant adeno-associated virus (rAAV)-mediated cardiac muscle, during acute myocardial infarction, a protective effect promote long-term functional recovery. Acute infarction the anterior LV wall induced in 12 chronically instrumented dogs by permanent occlusion LAD...
The aim of this study was to compare early outcomes and mid-term survival high-risk patients undergoing minimally invasive aortic valve replacement through right anterior mini-thoracotomy (RT) with sutureless valves versus transcatheter implantation (TAVI) for severe stenosis.From October 2008 March 2013, 269 stenosis underwent either RT perceval S (n = 178 patients, 66.2%) or TAVI 91, 33.8%: 44 transapical 47 trans-femoral). Of these, 37 the were matched a group by propensity score.Baseline...
Objective To define the benefit of sutureless and rapid deployment valves in current minimally invasive approaches isolated aortic valve replacement. Methods A panel 28 international experts with expertise both replacement was constituted. After thorough literature review, rated evidence-based recommendations a modified Delphi approach. Results No guideline could be retrieved. Thirty-three clinical trials 9 systematic reviews identified for detailed text analysis to obtain total 24...
Surgical aortic valve replacement (AVR) is increasingly performed in elderly patients with good perioperative outcomes and long-term survival, resulting significant health-related quality-of-life benefits. This study aimed to evaluate the outcome of aged ≥ 80 years undergoing isolated AVR through a right anterior minithoracotomy (RAMT) compare it full sternotomy (FS).Two hundred eighty-three or more underwent between February 2001 September 2013. With propensity score matching (1 : 1),...
Mitral valve (MV) repair is the gold standard for treatment of degenerative MV regurgitation. Recently, minimally invasive mitral surgery (MIMVS) has shown excellent postoperative outcomes compared with conventional surgery. The aim our study to report early and long-term patients undergoing MIMVS through right mini-thoracotomy (RT) over an eight year period.From September 2003 December 2011, a total 1,604 consecutive underwent RT.The mean age was 62±13 years, 295 (42%) were female 16 (2.3%)...
Liquid biopsy has dramatically changed cancer management in the last decade; however, despite huge number of miRNA signatures available for diagnostic or prognostic purposes, it is still unclear if dysregulated miRNAs bloodstream could be used to develop miRNA-based therapeutic approaches. In one author's previous work, nine were found early-stage colon (CRC) patients by NGS analysis followed RT-dd-PCR validation. present study, biological effects targeting most relevant with anti-miRNA...
From early experience in cardiac surgery on the mitral valve, access was gained different ways: through left and right antero-lateral extended thoracotomy for closed correspondingly open commissurotomy, from parasternal with rib resection, via median sternotomy. Median sternotomy remains most common approach valve procedures, such as replacement or repair, allowing good visualisation, exposure working field. Applying largely spread sternotomy, surgeons always wanted to overcome necessity of...
Transaortic left ventricular septal myectomy described by Morrow is a classical procedure for the treatment of systolic anterior motion mitral apparatus associated with hypertrophic obstructive cardiomyopathy (HOCM). We aimed to review our results transmitral and valve repair/replacement in patients intrinsic disease HOCM, operated on through minimally invasive approach.Between 2005 2014, 19 [7 men (37%); mean (SD) age, 69.4 (14.5) years] were treated approach degenerative regurgitation...
Aims of the study: In this prospective, randomized study, we investigate potential advantages vacuum-assisted venous drainage (VAVD), compared to gravitational (GD), in patients undergoing first-time coronary artery bypass graft (CABG) surgery, concerning biochemical markers organ and blood cell damage. Materials methods: Seventy-two consecutive were into two groups [‘Vacuum’ (VAVD) n= 36; ‘Not vacuum’ (GD) 36]. VAVD was achieved using a wall vacuum source with suction regulator connected...
Background: Meta-analyses of studies comparing transcatheter aortic valve implants (TAVIs) and sutureless replacement (SU-AVR) show differing effectiveness safety profiles. The approaches also differ in their surgical cost (including operating room device). Objective: objective this study was to assess the incremental cost-utility SU-AVR vs TAVIs for treatment intermediate- high-risk patients US, Germany, France, Italy, UK, Australia. Methods: A patient-level simulation compares in-hospital...
OBJECTIVESTriple valve surgery (TVS) is still a challenge for surgeons because of prolonged cardiopulmonary bypass (CPB) and myocardial ischaemic times. The reported operative mortality rate TVS ranges between 2.5 25%; long-term survival also diminished, with rates at 5 10 years 75–82 61–75%, respectively. objective our study to define early late clinical outcomes, reporting the initial experience in treatment triple disease through minimally invasive approach.
Few experiences exist in minimally invasive cardiac surgery for the treatment of double-valve disease. We report our early experience 69 patients, describing postoperative results. The introduction sutureless aortic prostheses has implemented this option, with a significant reduction cardiopulmonary bypass and cross-clamp times.
Objective: To define the benefit of sutureless and rapid deployment valves in current minimally invasive approaches isolated aortic valve replacement.Methods: A panel 28 international experts with expertise both replacement was constituted.After thorough literature review, rated evidence-based recommendations a modified Delphi approach.Results: No guideline could be retrieved.Thirty-three clinical trials 9 systematic reviews identified for detailed text analysis to obtain total 24...