A5058560746- Synthesis and characterization of novel inorganic/organometallic compounds
- Autophagy in Disease and Therapy
- Carbon Nanotubes in Composites
- Organoboron and organosilicon chemistry
- Nutrition and Health in Aging
- Coordination Chemistry and Organometallics
- Membrane Separation and Gas Transport
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Graphene research and applications
- Molecular Junctions and Nanostructures
- Advanced Glycation End Products research
- Chemotherapy-induced cardiotoxicity and mitigation
- Ammonia Synthesis and Nitrogen Reduction
- Cancer, Hypoxia, and Metabolism
- Hydrogen Storage and Materials
- Ferroptosis and cancer prognosis
- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Catalytic Cross-Coupling Reactions
- Muon and positron interactions and applications
- Polyoxometalates: Synthesis and Applications
- Catalysts for Methane Reforming
- Fullerene Chemistry and Applications
Nara Medical University
2023-2024
Osaka International Cancer Institute
2024
Nara City Hospital
2023
Kio University
2023
Research Institute of Innovative Technology for the Earth
2016-2021
Osaka Gas (Japan)
1996-2011
Materials Technology (United Kingdom)
2011
Material (Belgium)
2006
Kindai University
1997-1999
Anticancer agents are playing an increasing role in the treatment of gastric cancer (GC); however, novel anticancer have not been fully developed. Therefore, it is important to investigate compounds that improve sensitivity existing drugs. We reported pterostilbene (PTE), a plant stilbene, enhances antitumor effect low doses sunitinib cells accumulating mitochondrial iron (II) (mtFe) at doses. In this study, we investigated relationship between mtFe deposition and synergistic PTE different...
Electroreduction of dichlorosilanes, such as 1,1-dichlorodialkylsilanes, 1,2-dichlorotetra-alkyldisilanes, and 1,4-bis(chlorodialkylsilyl)benzenes, with Mg electrodes in a single-compartment cell was found to yield the corresponding polysilanes.
The electroreduction of alkylaryldichlorosilane carried out with Mg cathode and anode in a single compartment cell gave high molecular weight poly(alkylarylsilane) (M(n) = 5200-31000, M(w)/M(n) 1.4-1.8) 5-79% yield. effects electrode material, monomer concentration, amount supplied electricity, ultrasound were investigated. This electroreductive method was also successfully applied to the synthesis polygermanes, silane-geramane copolymers, poly[p-(disilanylene)phenylenes].
Patients with cancer die from cardiac dysfunction second only to the disease itself. Cardiotoxicity caused by anticancer drugs has been emphasized as a possible cause; however, details remain unclear. To investigate this mechanism, we treated rat cardiomyoblast H9c2 cells sunitinib, lapatinib, 5-fluorouracil, and cisplatin examine their effects. All increased ROS, lipid peroxide, iron (II) levels in mitochondria decreased glutathione peroxidase-4 GSH/GSSG ratio. Against background,...
Nutritional interventions are one focus of sarcopenia treatment. As medium-chain fatty acids (MCFAs) oxidized in the mitochondria and produce energy through oxidative phosphorylation (OXPHOS), they key parts nutritional interventions. We investigated vitro effects three types MCFA, caprylic acid (C8), capric (C10), lauric (C12), skeletal muscle cells. Compared with C10 C12, C8 promoted mitophagy phosphatase tensin homolog (PTEN)-induced kinase 1-Parkin pathway increased expression peroxisome...
5-aminolevulinic acid (ALA) is used for tumor-targeting phototherapy because it converted to protoporphyrin IX (PPIX) upon excitation and induces phototoxicity. However, the effect of ALA on malignant cells under unexcited conditions unclear. This information essential when administering systemically. We sarcoma cell lines that usually arise deep in body are rarely exposed light examine effects treatment (daylight lamp irradiation) dark (dark room) conditions. ALA-treated human SW872...
Water gas shift reaction of carbon monoxide (CO) with membrane reactors should be a promising method for hydrogen mass-production because its high CO conversion, purity and low dioxide emission. For developing such reactors, we need permselective membranes permeance order 10−6 mol m−2 s−1 Pa−1 at 573 K steam durability. In this study, have optimized the kind substrates, precursors, vapor concentration, chemical deposition (CVD) time using counter-diffusion CVD membranes. The developed...
MFI zeolite membranes were prepared by a secondary growth method on symmetric tubular supports. Adding fluoride ions to the synthesis gel significantly shortened hydrothermal time. In addition, with showed more than ten-times higher hydrogen permeation rate from conventional gel. membrane selectivity in hydrogen/toluene separation.
Methylcyclohexane-toluene system is one of the most promising methods for hydrogen transport/storage. The methylcyclohexane dehydrogenation can be exceeded by equilibrium conversion using membrane reactor. However, modularization reactor and manufacturing longer silica membranes than 100 mm are little developed. Herein, we have developed with practical length a counter-diffusion chemical vapor deposition method, module bundled multiple membranes. 500 mm-length had high permselective...
Cardiac disorders in cancer patients pose significant challenges to disease prognosis. While it has been established that these are linked cells, the precise underlying mechanisms remain elusive. In this study, we investigated impact of cancerous ascites from rat colonic carcinoma cell line RCN9 on H9c2 cardiomyoblast cells. We found reduced mitochondrial volume, increased oxidative stress, and decreased membrane potential leading apoptosis autophagy. Although fluid contained a substantial...
Skeletal muscle aging and sarcopenia result in similar changes the levels of markers. However, few studies have examined cancer from perspective aging. Therefore, this study investigated explored its causes vitro vivo. In mouse aging, cachexia, cachexia models, skeletal muscles showed markers including oxidative stress, fibrosis, reduced differentiation potential, telomere shortening. Furthermore, examination mitochondrial DNA revealed a 5 kb deletion major arc; truncation complexes I, IV, V...
Myocardial damage significantly impacts the prognosis of patients with cancer; however, mechanisms myocardial induced by cancer and its treatment remain unknown. We previously reported that medium-chain fatty acids (MCFAs) improve cancer-induced but did not evaluate differences in effect according to MCFA type. Therefore, this study investigated role inflammatory cytokines effects three types MCFAs (caprylic acid [C8], capric [C10], lauric [C12]). In a mouse model, C8 diet showed greater on...
Cancer sarcopenia is highly prevalent in patients with advanced cancer, which closely related to the disease prognosis. Overcoming cancer important for treatment. Cystine and theanine (CT), antioxidant amino acids, have been applied nutritional intervention of various diseases but their effects remain unclear on sarcopenia. We attempt examine effect CT Both mouse vitro cachexia models showed that reduced oxidative stress, inhibited autophagy apoptosis, improved phosphorylation suppression...
High-pressure adsorption isotherms of hydrogen onto amorphous carbon mesotubes (ACMs) prepared from fluorine polymer and activated fibres (ACFs) were measured at temperatures 77, 196 303 K, respectively, pressures up to 10 MPa. The for ACMs ACFs 77 K exhibited maxima 1 MPa (8.0 wt%) 4 (3.7 wt%), although both the Henry type amounts adsorbed 8 less than 0.3 wt%. maximum amount per unit micropore volume as determined by N 2 was 10-times larger that ACFs. are different in they thought have...
Abstract A new TiO2 nanotube (TiO2-NT) was synthesized utilizing a carbon template via the precursor of TiO2-coated (TiO2-CNT). The obtained TiO2-NT tubular in shape, several µm length, 100–150 nm external diameter, and around 30 inner diameter. mixed with nanoparticles to fabricate anodes dye-sensitized solar cells, showing an improvement conversion efficiency from 9.6% nonadditives 10.4% 2 wt % additives.
[Purpose] To assess the effects of continuous rehabilitation on intensive care unit-acquired weakness in a patient who underwent open-heart surgery. [Participant and Methods] This case report describes 78-year-old female developed after She cardiac surgery, via thoracotomy, for valvular disease angina pectoris. Her Medical Research Council sum score at time rehabilitative intervention was 28 points, indicating weakness. Rehabilitation continued, patient's physical function evaluated over...
[Purpose] The purpose of this study was to investigate the effects glucose intake on physical function in a heart failure rat model. [Materials and Methods] Five-week-old male Wistar rats were used for study. Monocrotalin (40 mg/kg) administered intraperitoneally induce failure. divided into two groups, control MCT; MCT group further classified according concentration (0%, 10%, 50%). [Results] Glucose during prevented loss body weight, skeletal muscle, fat mass. Myocardial metabolism...
[Purpose] Behavioral analysis is widely used in animal research. However, such requires specialized equipment and can be difficult to perform. Therefore, this study aimed explore validate a simple behavioral method. [Participants Methods] For assessments, Wistar rats were placed rearing cage videotaped from two directions: overhead side view. The filmed videos analyzed using ImageJ software calculate the distance traveled activity inactivity times of rats. Intraclass correlation coefficients...