A5108563209- Bacterial Infections and Vaccines
- Protease and Inhibitor Mechanisms
- Amoebic Infections and Treatments
- Bone health and treatments
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- RNA regulation and disease
- Carbohydrate Chemistry and Synthesis
- Polysaccharides Composition and Applications
- Proteins in Food Systems
- Genetic factors in colorectal cancer
- Animal Genetics and Reproduction
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Food Allergy and Anaphylaxis Research
- Soft tissue tumor case studies
- Ocular Diseases and Behçet’s Syndrome
- Magnesium in Health and Disease
- Bone Metabolism and Diseases
- Nicotinic Acetylcholine Receptors Study
- Genetic Syndromes and Imprinting
- bioluminescence and chemiluminescence research
- Apelin-related biomedical research
- Coronary Artery Anomalies
- Machine Learning in Materials Science
Japanese Red Cross Hokkaido College of Nursing
2025
Asahikawa Medical University
2025
Yokohama City University
2020
Hitachi (Japan)
2019
Hokuto Hospital
2019
Tokyo Metropolitan Children's Medical Center
2015-2016
Kitano Hospital
2012
St. Marianna University School of Medicine
1996-2010
National Institute of Infectious Diseases
1992-2010
Heidelberg University
2010
Management of intracranial epidural abscess (ICEA) typically requires a combination surgical drainage and antibiotic therapy. However, the indications for neurosurgical ICEA have not been well established by evidence-based data remain controversial. This article describes case that enlarged during therapy but was managed successfully without drainage. A 13-year-old boy admitted to authors' hospital with 6-day history high fever, fatigue, headache. Computed tomography magnetic resonance...
X-linked hypophosphatemia (XLH) is a group of rare disorders caused by defective proximal tubular reabsorption phosphate. Mutations in the PHEX gene are responsible for majority cases. There very few reports long-term complications XLH other than skeletal and dental diseases. The aim this study was to identify phenotypic presentation during adulthood including clinical biochemical phenotype 22 adult patients with mutation were examined retrospectively from their medical records. 6 had...
Immunoglobulin G (IgG) antibodies against purified cord factor (trehalose-6,6′-dimycolate) prepared from Mycobacterium tuberculosis H37Rv were determined by enzyme-linked immunosorbent assay (ELISA), and its diagnostic usefulness was evaluated. Serum specimens 65 patients with active pulmonary tuberculosis, 58 inactive 36 diseases other than 66 healthy adults examined. Patients showed significantly higher titers of IgG did groups (p < 0.001). The antibody titer greater 0.29 in absorption...
Sotos syndrome (SoS, OMIM #117550) is an overgrowth syndrome. Deletions or intragenic mutations of the NSD1 , which located at chromosome 5q35, are responsible for more than 75% SoS. Conventionally, neonatal hypoglycemia was reported briefly as one infrequent symptoms However, Matsuo et al. published a report describing five patients with SoS who presented transient hyperinsulinemic (HIH) in period. We on additional patient SoS, HIH All this and previous have microdeletions 5q35 chromosome....
Proteoglycan macrophage colony-stimulating factor (PG-M-CSF) was recently reported as a high molecular type of (M-CSF). We analyzed its structure by determining the expression mutant M-CSF cDNA in Chinese hamster ovary cells. PG-M-CSF contained two types molecules, homodimeric 150-200-kDa subunit and heterodimeric form 43-kDa subunit. The carries chondroitin sulfate chain, amino-terminal amino acid sequence identical to that subunit, which is known conventional molecule (85-kDa M-CSF)....
In this study, we synthesized antisense oligodeoxynucleotides (ODNs) with phosphodiester, phosphorothioate (S-ODNs), or methylphosphonate linkages complementary to the splicing acceptor site of immediate-early pre-mRNA 5 herpes simplex virus type 1 (HSV-1). The antiviral activity each analog on cytopathic effect in cells infected HSV-1 HSV-2 was assessed and compared cellular uptake analog. We found that S-ODNs showed most potent antiherpetic activity, 50% inhibitory concentrations microM...
ABSTRACT Selected functional properties of soybean protein heat denatured to different degrees were studied. Rheological (total breaking energy, Young's modulus) and water‐holding capacity gel improved by the preheat treatment applied during preparation protein. When proteins preheated in presence N‐ethylmaleimide (NEM) or 2‐mercaptoethanol (ME), improvement rheological was largely inhibited. But potassium bromate (KB r O 3 ), occurred. The formed from ground meat containing NEM‐treated...
Severe infant eczema on the face should be treated early because it may lead to allergic diseases in future. However, caregivers find difficult assess. A visual tool for is needed easily determine infants' facial skin condition severity based tool's scores. We developed an assessment (IFSAT) and evaluated its reliability validity.The IFSAT draft was results of a previous literature review qualitative sketch. Panels including medical professionals caregiver checked draft's content validity,...
Two new enzyme-linked immunosorbent assays (ELISAs) with chimeric fusion polypeptides for the detection of human antibodies specific to Epstein-Barr virus nuclear antigen 1 (EBNA-1) are described. One is an indirect ELISA affinity-purified beta-galactosidase-EBNA-1 protein as antigen. The other a "sandwich" assay based on use anti-beta-galactosidase antibody capture proteins in bacterial extracts. A good correlation was shown between titers determined by EBNA-1 and those conventional...
Spondyloepiphyseal dysplasia tarda (SEDT; MIM # 313400) is a rare X-linked recessive skeletal disease characterized by disproportionate short stature with vertebral malformation and degenerative changes involving the spine major joints (1). During infancy early childhood, affected males show normal development unremarkable findings on radiographs Clinical expression of SEDT begins flattening growth curve before puberty. At this time, characteristic deformities vertebrae, including...
Immunization of health care personnel (HCP) is critically important to reduce healthcare-associated influenza infections substantially. During 2009–2010, 74% all HCP at Kitano Hospital, Osaka, Japan, including 94% pediatricians, received the monovalent unadjuvanted A (H1N1) pdm09 vaccine. We evaluated vaccine's immunogenicity. Sixteen pediatricians 15 μg hemagglutinin antigen subcutaneously. Antibody titer assays were conducted using hemagglutination-inhibition antibody assay on days 0 and...