A5065732586- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Systemic Sclerosis and Related Diseases
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Immune Cell Function and Interaction
- Organic Light-Emitting Diodes Research
- Viral-associated cancers and disorders
- Long-Term Effects of COVID-19
- Multiple Myeloma Research and Treatments
- Nanowire Synthesis and Applications
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Vestibular and auditory disorders
- Ga2O3 and related materials
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Biomedical Ethics and Regulation
- Organic Electronics and Photovoltaics
Ospedale Papa Giovanni XXIII
2018-2025
Humanitas University
2017-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
IRCCS Humanitas Research Hospital
2023-2025
University of Salento
2021-2024
Fondazione Humanitas per la Ricerca
2017
Abstract Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function cancer remains unclear. Here we show that, acute promyelocytic leukaemia (APL), ILC2s increased hyper-activated through the interaction of CRTH2 NKp30 with elevated tumour-derived PGD2 B7H6, respectively. ILC2s, turn, activate monocytic myeloid-derived suppressor (M-MDSCs) via IL-13 secretion. Upon treating APL all-trans retinoic acid...
Despite the impressive results of chimeric antigen receptor (CAR) T cell treatment for lymphomas, adverse events such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity (ICANS), and infections are major issues that can lead to intensive care unit (ICU) admission death. Current guidelines recommend tocilizumab treating patients with CRS grade (G) ≥2; however, optimal timing intervention has yet be determined. Our institution adopted preemptive use in cases...
This study reports a unique case of West Nile Virus (WNV)-associated multilevel macular ischemia, involving retinal capillary plexuses and choriocapillaris, confirmed through real-time polymerase chain reaction (RT-PCR) aqueous humor characterized using advanced multimodal imaging. A 35-year-old immunocompromised male presented with bilateral, acute, painless visual loss persisting for 14 days. Ophthalmic evaluation included ultra-widefield fundus photography, spectral-domain optical...
Allogeneic stem cell transplantation (allo-SCT) from HLA-identical donors (HLAid) could be an effective salvage treatment for relapsed/refractory lymphoma. In this setting, standard graft-versus-host disease (GVHD) prophylaxis is based on cyclosporine and methotrexate, with the addition of anti-thymocyte globulin, at least matched, unrelated donors. Promising data using post-transplant cyclophosphamide (PT-Cy) have been reported retrospective studies in patients receiving allo-SCT HLAid...
Textile-based electronics represents a key technology for the development of wearable devices. Light-emitting textiles based on OLED architecture are particularly promising due to their intrinsic flexibility and possibility be fabricated large areas using scalable processes. Fabric planarization is one most critical issues in fabrication. Here we report fast, simple, industrially method transfer surface morphological properties from silicon fabric. A liquid resin used as layer, by exploiting...
Abstract Cytokine release syndrome (CRS) represents a life‐threatening side effect after haploidentical stem cell transplantation (Haplo‐SCT) with posttransplant cyclophosphamide (PT‐Cy). Factors predictive of CRS development is still matter debate. We retrospectively analyzed 102 consecutive patients receiving bone marrow (BM) (n = 42) or peripheral blood cells (PBSC) 60) Haplo‐SCT PT‐Cy. The two cohorts were similar in main patients’ characteristics besides disease type ( P .02)....
SARS-COV2 pandemic has caused profound challenges in health care systems worldwide. Patients affected by hematological neoplasms appear to be particularly at risk of developing COVID-19 complications, with unfavorable outcomes.
 Here, we present the case a 57-years-old woman diagnosed severe pneumonia and concurrent acute myeloid leukemia (AML). At time diagnosis, it was decided postpone therapy enable adequate treatment. When her conditions related improved, combination...
Abstract The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1 ‐ JAK2 fusion protein leading to constitutive activation Janus Kinase 2 that renders this disease potentially sensitive ruxolitinib. Here, we report an interesting case myeloproliferative neoplasm evolving myeloid sarcoma and B precursor ALL.
The introduction of novel drugs (
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A corrugated Dion–Jacobson 2D perovskite has been integrated with a 3D MAPbBr 3 by using blend and bilayer approach for application in light emitting diodes.
BACKGROUND: An aspect of COVID-19 baffling physicians is the presentation patients with acute respiratory failure, but normal mental faculties and no perception dyspnea (i.e. "silent hypoxemia"). The aim this study was to investigate frequency, characteristics, outcome silent hypoxemic status comparing them a symptomatic severity-matched group.METHODS: This retrospective monocentric observational involving all PCR confirmed SARS-CoV-2 pneumonia, admitted at Papa Giovanni XXIII Hospital,...
Abstract Background Immune effector cell–associated neurotoxicity syndrome (ICANS) is a frequent complication of chimeric antigen receptor (CAR) T-cell therapy. Most patients achieve complete symptom resolution without long-term neurological sequelae, yet the impact ICANS and steroid therapy on oncological outcomes remains inadequately explored. We investigated association between with progression-free survival (PFS). Methods included large B-cell lymphoma treated anti-CD19 CAR T cells. The...