A5108420464- Advanced Glycation End Products research
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- Skin Protection and Aging
- Gut microbiota and health
- Biochemical effects in animals
- Bee Products Chemical Analysis
- 3D Printing in Biomedical Research
- Polysaccharides and Plant Cell Walls
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Plant Reproductive Biology
- Probiotics and Fermented Foods
- Antioxidant Activity and Oxidative Stress
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Biochemical Analysis and Sensing Techniques
- Coenzyme Q10 studies and effects
- solar cell performance optimization
- Forest Insect Ecology and Management
- Sirtuins and Resveratrol in Medicine
- Insect Pheromone Research and Control
- Coronary Artery Anomalies
- Polyamine Metabolism and Applications
LVMH (France)
2013-2025
Centre National de la Recherche Scientifique
2024
Université de Bourgogne
2024
Institut de Chimie Moléculaire de l'Université de Bourgogne
2024
AgroParisTech
2019
Christian Dior (France)
2007
Laboratoire de Probabilités et Modèles Aléatoires
2006-2007
Université de Montréal
2006
Inserm
2003
École Pratique des Hautes Études
2003
Abstract A 7‐year‐old neutered male domestic shorthair was referred for an investigation into jaundice. The cat had a recent history of vomiting, anorexia and pyrexia. Serum biochemistry demonstrated marked hyperbilirubinaemia. An abdominal ultrasound revealed severe cholangitis cholecystitis associated with common bile duct obstruction by linear structure suggestive foreign body. choledochotomy performed to catheterise the push body (grass awn) duodenum through major duodenal papilla,...
Abstract In the gut ecosystem, microorganisms regulate group behaviour and interplay with host via a molecular system called quorum sensing (QS). The QS molecule 3-oxo-C12:2-HSL, first identified in human microbiota, exerts anti-inflammatory effects could play role inflammatory bowel diseases where dysbiosis has been described. Our aim was to identify which signalling pathways are involved this effect. We observed that 3-oxo-C12:2-HSL decreases expression of pro-inflammatory cytokines such...
Sun exposure is the major environmental influence for epidermal cells; harmful effect of UV radiation on skin related to generation reactive oxygen species that alter cellular components including proteins. It now well established proteasome responsible degradation most oxidized proteins and impairment function a hallmark aging. In previous study, we investigated effects irradiation proteasomes in human keratinocyte cultures showed all three peptidase activities were decreased 24 h after...
Cellular aging is characterized by the accumulation of oxidatively modified proteins that result, at least in part, from impaired degradation abnormal proteins. The proteasome major intracellular proteolytic system implicated removal and oxidized In human epidermal cells, previous studies have evidenced function decreased during as well upon UV irradiation, which main component photoaging. age-related decline activity has been reported to be due either or both subunits expression content,...
Ultraviolet A (UVA) (320–400 nm) radiation is known to cause cutaneous aging and skin cancer. We studied the effect of UVA (365 on human epidermis by focusing keratinocyte gap junction-mediated intercellular communication (GJIC). observed a dose-dependent 10-fold decrease in GJIC induced normal keratinocytes. This was associated with time-dependent internalization connexin43 (Cx43). also damaged actin cytoskeleton, as shown microfilament disappearance. Importantly, transient when...
RésuméLes maladies vasculaires sont caractérisées parallèlement par une épinastie et décoloration foliaires intense « gommose » plus ou moins colorée qui envahit lexylème de la tige. La production substances «gommeuses chez l'Œillet l'Orme infectés leurs parasites spécifiques, le Phialophora cinerescens Ceratocystis ulmi, a été comparée à celle infecté expérimentalement Verticillium dahliae, parasite vasculaire non pathogène pour l'Œillet, bien que très polyphage. Dans tous les cas, nous...
Modification of proteins by reactive oxygen species is implicated in different disorders. The proteasome a multicatalytic proteinase charge intracellular protein turnover and oxidized degradation. Consequently, function very important controlling the level altered eukaryotic cells. Evidence for decline activity during skin photo-aging has been provided Bulteau et al. 2002. ability lipid algae extract (Phaeodactylum tricornutum) to stimulate 20S peptidase activities was described Nizard 2001....
ABSTRACT Secretory activity is triggered off in xylem contact cells when the neighbouring vessels are stressed. The nature and intensity of secretion depend upon stress (wounding, infection with a pathogenic or non-pathogenic vascular parasite). Various metabolites synthesized, among which carbohydrates polyphenols conspicuous. These products can be discharged through pits into lining where they produce considerable gummosis. Secretion dynamics were studied detail carnation plants.
Heat shock protein (HSP) 47 is a specific chaperone of procollagen. This heat responsible for the correct three-dimensional organization procollagen and its control-quality prior secretion. The aim study to evaluate level HSP in aged, photoaged, senescent fibroblasts modulation by plant extract (Salix alba). and/or expression was measured real-time RT-PCR (mRNA transcripts) flow cytometry (immunochemistry technique measurement arbitrary fluorescence intensity). Immunochemistry techniques...
The cells abutting the vessels in primary xylem of healthy melon exhibit characteristics contact cells. These also produce a protective layer and transfer-cell-like thickenings. wall is partially if not totally hydrolysed at level pits. After infection by Fusarium oxysporum f. sp. melonis Sn. ' H., resistant plants show strong cytoplasmic activity leading to growth tyloses into lumen vessels. Such tylosis formation occurs rapidly helped material stored ingrowths which reorganised single...
Objective: This study explored the impact of a black tea extract obtained through (plant small RNA) PSRTM technology, characterized by its abundance molecules, particularly citric acid—an antioxidant and tricarboxylic acid (TCA) cycle contributor—on mitochondrial health. The primary focus was to assess whether this could counteract reactive oxygen species (ROS)-induced alterations associated with aging, which lead impaired function, reduced ATP production, increased ROS generation. Methods:...
Abstract Reconstructed human epidermis equivalents (RHE) have been developed as a clinical skin substitute and the replacement for animal testing in both research industry. KiPS, or keratinocytes derived from induced pluripotent stem cells (iPSCs) are frequently used to generate RHE. In this study, we focus on mitochondrial performance of KiPS iPSCs obtained two donors. We found that older donor more defective mitochondria. Treatment these with plant extract enriched compounds known protect...