A5016740252- Bacillus and Francisella bacterial research
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- HIV, Drug Use, Sexual Risk
- Advanced Proteomics Techniques and Applications
- Radioactive contamination and transfer
- Viral gastroenteritis research and epidemiology
- Veterinary medicine and infectious diseases
- Cell Image Analysis Techniques
- Radioactive element chemistry and processing
- Genetics, Bioinformatics, and Biomedical Research
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Microbial Community Ecology and Physiology
- Neurological disorders and treatments
- Substance Abuse Treatment and Outcomes
- Computational Drug Discovery Methods
- Zoonotic diseases and public health
- Endoplasmic Reticulum Stress and Disease
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Salivary Gland Tumors Diagnosis and Treatment
- Microbial bioremediation and biosurfactants
- Neurotransmitter Receptor Influence on Behavior
- Genetically Modified Organisms Research
Argonne National Laboratory
2005-2024
Urbana University
1994-1998
University of Illinois Urbana-Champaign
1994-1998
Bacillus anthracis, the causative agent of anthrax, is a highly virulent zoonotic pathogen primarily affecting domesticated and wild herbivores. Human exposure to B. anthracis through contact with infected animals or contaminated animal products. In Pakistan, where livestock vaccines are largely unavailable carcasses often disposed improperly, risk humans, wildlife significant. Currently, diagnosis anthrax infections outbreak tracing necessitates isolation culturing process that requires...
Botulinum neurotoxin (BoNT) presents a significant hazard under numerous realistic scenarios. The standard detection scheme for this fast-acting toxin is lab-based mouse lethality assay that sensitive and specific, but slow (∼2 days) requires expert administration. As such, efforts have aimed to decrease analysis time reduce complexity. Here, we describe ratiometric fluorescence resonance energy transfer utilizes highly photostable semiconductor quantum dot (QD) donors chromophore...
The convergence of advances in biotechnology with laboratory automation, access to data, and computational biology has democratized accelerated the development new therapeutics. However, increased digital age also introduced additional security concerns ultimately, spawned discipline cyberbiosecurity, which encompasses cybersecurity, cyber-physical security, biosecurity considerations. With emergence this comes need for a logical, repeatable, shared approach evaluating facility system...
Protein profiling and characterization of protein interactions in biological samples ultimately require indicator-free methods signal detection, which likewise offer an opportunity to distinguish specific from nonspecific binding. Here we describe a new 3-dimensional microchip for detecting biomolecular with matrix-assisted laser desorption-ionization mass spectrometry (MALDI-MS); the comprises high-density array methacrylate polymer elements containing immobilized proteins as capture...
Summary Conventional vaccination with the cocaine molecule conjugated to a protein carrier is new approach in treatment of addiction. Experimentally, this strategy has been shown alter pharmacokinetics as well psychostimulant effect challenge. The purpose study was investigate whether more stable and less controversial molecule, an anti‐idiotypic antibody, which mimics configuration (Ab2β), could be successfully used instead cocaine. Two conjugates that presented different areas immune...
Anthrax, caused by Bacillus anthracis (B.anthracis), is an important zoonotic disease of livestock that poses a threat to public safety.The present study aimed determine the seroprevalence in sheep and cattle endemic areas (Punjab Balochistan provinces) Pakistan enzyme-linked immunosorbent assay (ELISA).Crosssectional survey was also done assess control measures farmers.Out 401 serum samples from cattle, total 68 (16.9%) were seropositive for anti-PA antibodies; B. 22.11% (48/217) 10.86%...
Anthrax, a severe zoonotic disease, is infrequently reported in anthrax-endemic regions of Pakistan. Despite clinical reports indicating its presence, particularly cutaneous anthrax, there insufficient laboratory evidence regarding disease occurrence and environmental persistence. The present study aimed to confirm Bacillus anthracis accountable for animal mortality human infection, while exploring transmission factors. Between March 2019 July 2021, total 19 outbreaks were documented. Of...
Abstract Chemicals involved in plutonium uranium reduction extraction (PUREX) have the potential to be released from nuclear reprocessing facilities and accumulate environment. In order understand how soil microbial communities respond contamination by PUREX chemicals, we carried out a series of microcosm experiments, exposing chemically diverse soils range concentrations key chemicals used process. We tested 4 5 types using 16S rRNA amplicon sequencing, determining that responses are...