A5086313746- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Galectins and Cancer Biology
- Mathematical Biology Tumor Growth
- interferon and immune responses
- Cancer Cells and Metastasis
- Fungal Biology and Applications
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Bowel Disease
- Ferroptosis and cancer prognosis
- Chemokine receptors and signaling
- Sirtuins and Resveratrol in Medicine
- Colorectal and Anal Carcinomas
Soochow University
2018-2025
The First People's Hospital of Changzhou
2024
University of Pittsburgh
2020-2023
Shanghai Cell Therapy Research Institute
2023
Gastric cancer is one of the leading causes cancer-related death due to late diagnosis with high metastatic frequency. In this study, impact tumor secreted exosomes on immune function in environment was investigated using isolated from gastric cell lines MKN-28, MKN-45, and SGC-7901. Results show that derived all these changed gene expression cytokine secretion levels CD8+ T cells. They also block cycle progression, induced apoptosis Image analysis fluorescent labeled three injected...
Although microwave ablation (MWA) is an important curative therapy in colorectal cancer liver metastasis, recurrence still occurs clinically. Our previous studies have shown that the expression of programmed cell death 1 ligand (PD-L1) upregulated following MWA, suggesting MWA combined with anti-PD-L1 treatment can serve as a promising clinical therapeutic strategy against cancer. Using MWA-treated preclinical mice models, αPD-L1 decreased tumor growth and prolonged overall survival (OS)....
In "healthy" tumor cells, phosphatidylserine (PS) is predominately localized in the inner plasma membrane leaflet. During apoptosis, PS relocates to outer Herein, we established PSout models with cells lacking flippase component CDC50A, constantly exposing but alive. tumors developed bigger than wild-type (WT) tumors, featuring M2 polarized tumor-associated macrophages (TAMs) and fewer tumor-antigen-specific T cells. The receptor TIM-3 responsible for recognition. Employing an opposite...
It is well-known that CD226 serves as a critical activating receptor on various immune cells, such lymphocytes and monocytes, it suggested to promote anti-tumor immunity in the tumor microenvironment (TME). Herein, we showed crucial regulatory role of CD8 + T cell-mediated response TME human gastric cancer (GC). Specifically, increased expression tissues was significantly associated with better clinical outcomes GC patients. Moreover, infiltrating cells ratio subpopulation within could also...
The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. resistance to ICB is likely due compensatory upregulation of additional inhibitory molecules. In this study, we first systematically examined Tim-3 expression in cells mouse tumors and found that was specifically up-regulated a large number Treg, conventional CD4+, CD8+ T cells, dendritic cell 1 (DC1), macrophage (M1) tumor microenvironment (TME)....
Hairy and enhancer of Split 4 (HES4) is thought to have a substantial impact on the pathogenesis progression malignancies. However, prognostic significance mechanism HES4 not been reported in Hepatocellular carcinoma (HCC). A comprehensive bioinformatics analysis expression, clinicopathological characteristics, tumor microenvironment status, drug sensitivity were performed based TCGA, GTEx, GEO. Paired HCC samples cell lines used validate dysfunction vitro. The expression at both mRNA...
In the era of immune checkpoint blockade cancer therapy, cytokines have become an attractive therapeutics to increase response rates. Interleukin 21 (IL21) as a single agent has been evaluated for treatment with good clinical efficacy. However, application IL21 is limited by short half-life and concern about potential suppressive effect on dendritic cells. Here, we examined antitumor function extended alone in combination PD-1 using preclinical mouse tumor models. We also determined...
Both preclinical and clinical studies have extensively proven the effectiveness of TIGIT inhibitors in tumor immunotherapy. However, it has been discovered that presence CD226 on tumor-infiltrating lymphocytes is crucial for both anti-TIGIT therapy alone when combined with anti-PD-1 tumors. In our investigation, we observed cordycepin significantly augmented expression Cd226 gene. As a result, was hypothesized could enhance therapy. By employing single-cell RNA sequencing analysis immune...
Exhausted CD8 + T cells represent a distinct cellular lineage that emerges during both chronic infections and cancers. Recent studies have shown persistent antigen exposure can drive the differentiation of precursor exhausted cells, termed pex which are characterized as TCF-1 PD-1 cells. Elevated cell frequencies in tumor microenvironment (TME) associated with improved overall survival (OS) cancer patients heightened responsiveness to anti-PD-1 therapy. In our present study, we utilized...
Abstract Despite the success of immune checkpoint inhibitors (ICIs) in treating solid tumors, lots patients remain unresponsive to this therapy. Microwave ablation (MWA) stimulates systemic adaptive immunity against tumor cells by releasing antigens. Additionally, IL-21 has demonstrated importance stimulating T-cell effector function. The combination these three therapies—MWA, IL-21, and anti-PD-1 monoclonal antibodies (mAbs)—has yet be explored context cancer treatment. In study, we impact...
T cell-stimulating cytokines and immune checkpoint inhibitors (ICI) are an ideal combination for increasing response rates of cancer immunotherapy. However, the results clinical trials have not been satisfying. It is important to understand mechanism synergy between these two therapeutic modalities. Here, through integrated analysis multiple single-cell RNA sequencing (scRNA-seq) datasets human tumor-infiltrating cells, we demonstrate that IL21 produced by tumor-associated follicular helper...
Abstract CD8 + T cells secreting granzyme A (GZMA) can induce pyroptosis in tumor by effectively cleaving gasdermin B (GSDMB), which is stimulated interferon-γ (IFN-γ). However, the interaction between GZMA-expressing and GSDMB-expressing colon cancer remains poorly understood. Our research employed multi-color immunohistochemistry (mIHC) staining integrated clinical data to explore spatial distribution relevance of GZMA- IFN-γ-expressing tumor-infiltrating lymphocytes (TILs), as well CK...
Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that RIG-I play an important role in oncogenesis cancer progression well. As of now, the expression gastric still remain largely unexplored. In this study, we investigated clinical associations human tissues further explore its contribution regulation malignant phenotype...
Summary: Immune checkpoint blockade therapy is a pivotal approach in treating malignant tumors. TIGIT has emerged as focal point of interest among the diverse targets for tumor immunotherapy. Nonetheless, there still lack comprehensive understanding regarding immune microenvironment alterations following treatment. To bridge this knowledge gap, we performed single-cell sequencing on mice both before and after administration anti-TIGIT therapy. Our analysis revealed that was predominantly...
Abstract Background Lung adenocarcinoma (LUAD) is a highly lethal form of lung cancer. Despite advancements in treatments, managing LUAD still challenging due to its aggressive behavior. Recent studies indicate that various molecular pathways, including the dysregulation ferredoxin 1 (FDX1), play roles progression. FDX1, crucial protein cellular redox reactions and energy metabolism, has been linked several cancers. However, exact role development not yet fully understood. Methods We...
Abstract Nuclear regulation has potential in cancer therapy, with the nuclear pore complex (NPC) serving as a critical channel between nucleus and cytoplasm, playing role regulating various biological processes cancer. DNA methylation, an epigenetic modification mediated by methyltransferases (DNMTs), influences gene expression cell differentiation, is crucial for development progression of tumor cells. Gliomas are most common primary brain tumors, glioblastoma being particularly aggressive,...