Abstract Background It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated even though circRNAs generally regulate gene expression through miRNA sponges, they may encode small peptides in pathogenesis. However, it remains largely unexplored whether are involved the tumorigenesis of colon cancer (CC). Methods The profiles CC tissues were assessed by circRNA microarray. Quantitative real-time PCR,...

Abstract Background N‐acetyltransferase 10 ( NAT10 ) is the only enzyme known to mediate N4‐acetylcytidine (ac4C) modification of mRNA and crucial for stability translation efficiency. However, its role in cancer development prognosis has not yet been explored. This study aimed examine possible colon cancer. Methods The expression levels were evaluated by immunohistochemical analyses with a tissue microarray, prognostic value patients was further analyzed. Quantitative real‐time polymerase...

Aberrant activation of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin containing 3 (NLRP3) inflammasome drives development many complex inflammatory diseases, such as obesity, Alzheimer's disease, atherosclerosis. However, no medications specifically targeting NLRP3 have become clinically available. Therefore, we aim to identify new inhibitors in this study. Methods: Vesicle-like nanoparticles (VLNs) were extracted from garlic chives other Allium vegetables...

Gastric cancer (GC) is the fifth most common tumor and third deadly worldwide. N6-methyladenosine (m

It is well known that human clear cell renal carcinoma (ccRCC) a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest the immune checkpoint blockade therapy an important breakthrough in treatment against ccRCC. HHLA2, recently reported member of B7 family, uniquely expressed humans but not mice, it plays role functional inhibition CD4 CD8 T cells. Herein, we aimed to study clinical implications HHLA2 expression ccRCC its potential regulatory biological functions...

Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that Nectin-4 over-expressed multiple human cancers, such abnormal expression associated with cancer progression poor prognosis of patients. In present study, we aimed to characterize pattern esophageal (EC) tissues, investigate its clinical implications, prognostic value regulatory effects on cellular functions EC cells. first examined tissues by...

Abstract: Gliomas are the most common malignant primary brain tumors, and new clinical biomarkers therapeutic targets imminently required. MicroRNAs (miRNAs) a novel class of small non-coding RNAs (~22nt) involved in regulation various biological processes. Here, by using real-time polymerase chain reaction, miRNA-132 was found to be significantly deregulated glioma tissues. Based on prediction target genes miR-132, we hypothesized that there is significant association between miR-132 matrix...

IL-1β is an essential factor of inflammation initiation, and it also promotes malignant transformation, indicating its tumorigenic property. We aimed to investigate the correlation between miR-144-3p as well their prognostic values in LUAD LUSC patients.The level both patients was significantly higher than that healthy donors (P < 0.001). In populations, with low had better prognosis high 0.001 P = 0.010, respectively). A549 cells, miR-144 showed biggest expression change (-4.38 fold) after...

Lung adenocarcinoma (LUAD) is a major subtype of non-small-cell lung cancer, which the leading cause cancer death worldwide. The histone H3K36 methyltransferase SETD2 has been reported to be frequently mutated or deleted in types human cancer. However, functions tumor growth and metastasis LUAD not well illustrated. Here, we found that was significantly downregulated greatly impaired proliferation, migration, invasion vitro vivo. Furthermore, overexpression attenuated epithelial-mesenchymal...

With the advent of large-scale molecular profiling, an increasing number oncogenic drivers contributing to precise medicine and reshaping classification lung adenocarcinoma (LUAD) have been identified. However, only a minority patients archived improved outcome under current standard therapies because dynamic mutational spectrum, which required expanding susceptible gene libraries. Accumulating evidence has witnessed that understanding regulatory networks as well their changing processes was...

T-cell immunoglobulin and mucin domain 1 (TIM-1) is an important co-stimulatory molecule which serves as a surface marker for T cell activation, especially Th2 cells. Recently, many studies have also shown that TIM-1 can be abnormally expressed in human cancers may potential role promoting cancer progression.The immunohistochemistry was used to examine the expression non-small-cell lung carcinoma (NSCLC) tissues. The cellular were performed investigate of regulation biological functions...

Ovarian cancer is one of the leading causes mortality in women. Since little clinical symptoms were shown early period ovarian cancer, most patients found phases III-IV or with abdominal metastasis when diagnosed. The lack effective diagnosis biomarkers makes difficult to screen. However, essence, fundamental problem we know very about regulatory mechanisms during tumorigenesis cancer. There are emerging factors, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), which have played...

Hepatocellular carcinoma (HCC) represents a substantial global health burden. Tumorinfiltrating B lymphocytes (TIL-Bs) contribute to tumor progression and significantly impact the efficacy of therapy. However, characteristics TIL-Bs in HCC their effect on therapy remain elusive. Single-cell RNA sequencing (scRNAseq) was applied investigate heterogeneity, cellular differentiation cell-cell communication HCC. Further, Cancer Genome Atlas-liver hepatocellular (TCGA-LIHC) liver cancer institutes...

Recent studies have suggested that B7-H6, a new member of the B7 family ligands, not only is crucial regulator NK cell-mediated immune responses but also has important clinical implications due to its abnormal expression in many human cancers. We previously reported higher B7-H6 levels ovarian cancer tissues are positively correlated with tumor metastasis and progression. To date, hepatocellular carcinoma (HCC) significance still remain elusive.In present study, level was examined both HCC...

Human saliva is rich in proteins, which have been used for disease detection such as oral diseases and systematic diseases. In this paper, we present a computational method predicting secretory proteins human based on two sets of from published literatures public databases. One set contains known can be secreted into saliva, the other that are deemed to not extracellular secretion. The protein features with discerning power between were firstly gathered. Then classifier was trained...

The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be frequently mutated or deleted in many types of human cancer. However, the role SETD2 lung adenocarcinoma (LUAD) not well documented. In present study, we found that was significantly down-regulated both LUAD tissues and cell lines. Functionally, increased expression attenuated proliferation cancer cells by affecting cycle, whereas deficiency dramatically improved these proliferative abilities...

Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that RIG-I play an important role in oncogenesis cancer progression well. As of now, the expression gastric still remain largely unexplored. In this study, we investigated clinical associations human tissues further explore its contribution regulation malignant phenotype...

The aim of the study was to measure expression microRNA (miR)-181b in patients with lung cancer, investigate its biological function and elucidate underlying mechanisms associated development cancer.miR-181b tissues measured via RT-qPCR. After A549 cells were transfected miR-181b mimic or si-Sox6, proliferation, migration cell cycle distribution evaluated using counting kit-8 assay, transwell assay flow cytometry. levels cycle-related proteins Sox6 analyzed by western blotting. Gene targets...

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