A5030543101- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Land Use and Ecosystem Services
- Gastric Cancer Management and Outcomes
- Remote Sensing and Land Use
- Epigenetics and DNA Methylation
- Remote Sensing in Agriculture
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- Bioactive Compounds in Plants
- Phytochemical compounds biological activities
- Colorectal and Anal Carcinomas
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Iron Metabolism and Disorders
- Arsenic contamination and mitigation
- Immunotherapy and Immune Responses
- Chemotherapy-induced organ toxicity mitigation
First People's Hospital of Yunnan Province
2021-2025
Kunming University of Science and Technology
2021-2025
Soochow University
2013-2024
Songjiang District Central Hospital
2024
Tianjin Children's Hospital
2023
Tianjin University
2023
Peking University
2022-2023
Linyi University
2023
Guizhou Provincial People's Hospital
2019-2022
The First People's Hospital of Changzhou
2020-2022
This study was aimed to detect the correlation among EGFR/KRAS status and PD-1/PD-L1 expression in non-small-cell lung cancer (NSCLC) patients. PD-1 PD-L1 expressions were detected by immunohistochemistry 100 surgically resected adenocarcinoma tissues statistically correlated with clinicopathological characteristics including EGFR KRAS statuses. Besides, overall survival (OS) times analyzed. There a statistical significances between tumor (P = 0.043), higher mutation rate lower significance...
Abstract Tumor cells primarily employ the PD-1/PD-L1 pathway to thwart anti-tumor capabilities of T lymphocytes, inducing immunosuppression. This occurs through direct interaction PD-L1 with PD-1 on lymphocyte surfaces. Recent research focusing tumor microenvironment has illuminated pivotal role immune cells, particularly tumor-associated macrophages (TAMs), in facilitating PD-L1-mediated Exosomes, characterized by their ability convey information and be engulfed significantly contribute...
ABSTRACT Background Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types and SUA levels remains undetermined. Methods Bidirectional Mendelian randomization (MR) analysis based on genome‐wide association studies was used to assess relationship risk in European Asian populations. Results Forward MR showed significantly associated with lower ( p = 0.0013). The estimated effect...
Lung adenocarcinoma (LUAD) is a major subtype of non-small-cell lung cancer, which the leading cause cancer death worldwide. The histone H3K36 methyltransferase SETD2 has been reported to be frequently mutated or deleted in types human cancer. However, functions tumor growth and metastasis LUAD not well illustrated. Here, we found that was significantly downregulated greatly impaired proliferation, migration, invasion vitro vivo. Furthermore, overexpression attenuated epithelial-mesenchymal...
B7-H4 is a novel B7 ligand that plays an important role in the T cell-mediated immune response as negative regulator. Previous studies have suggested aberrant expression of membrane tumor cells. The aim this study to determine levels preoperative soluble (sB7-H4) circulation and investigate correlations between sB7-H4 clinicopathological parameters well survival rate patients with gastric cancer. Blood specimens from 132 cancer 63 healthy volunteers were analyzed by sandwich enzyme-linked...
Aim: The aim of this study was to determine the expression levels serum ferritin (SF) and investigate correlation between SF clinical characteristics as well efficacy platinum-based chemotherapy for advanced non-small cell lung cancer (NSCLC) patients. Materials Methods: Electrochemiluminescence method used in peripheral blood 46 NSCLC patients 63 healthy subjects. Results: subjects were significantly lower than those with (t = −3.279,P 0.001). There a statistically significant difference...
Objectives: To investigate the association between ambient air pollutant exposure and daily hospital admissions for respiratory diseases in children Guiyang. Methods: Clinical data of pediatric inpatients with disease from 2009 to 2016 Guizhou Provincial People’s Hospital PM2.5, NO2, PM10 SO2 concentration were retrieved. A canonical correlation analysis (CCA) was applied analyse pollutants diseases. reproducibility pollution duration direct cost hospitalization. The support vector...
This study determined the levels of serum ferritin (SF) and carcinoembryonic antigen (CEA) in elderly patients with advanced primary lung cancer (PLC), aimed to investigate correlation between SF level clinical characteristics compare positive rates CEA PLC those normal subjects. The 69 cases 63 controls were by electrochemiluminescence method. each independent clinicopathological characteristic was calculated. subjects compared. results revealed that significantly lower than LC (145.04 ±...
Abstract Purpose Long non-coding RNAs (lncRNAs) play important roles in the development of pneumonia. We aimed to explore role lncRNA KCNQ1OT1 pneumonia and its underlying mechanisms. Methods The expression KCNQ1OT1, FOXM1, miR-370-3p was detected serum 24 children with healthy controls. Normal human embryonic lung-derived diploid fibroblasts (WI-38 cells) were stimulated LPS (10 μg/mL) simulate cellular model pneumonia, cell viability, apoptosis, inflammation analysed. Dual luciferase...
Orthosiphon stamineus Benth is a dietary supplement and traditional Chinese herb with widespread clinical applications, but comprehensive understanding of its active compounds polypharmacological mechanisms lacking. This study aimed to systematically investigate the natural molecular O. via network pharmacology.Information on from was collected literature retrieval, while physicochemical properties drug-likeness were evaluated using SwissADME. Protein targets screened SwissTargetPrediction,...
Unprecedented durable responses are identified in clinical studies to target the signaling of programmed cell death protein-1 (PD-1) as well its ligand (PD-L1) patients with squamous-cell non-small lung cancer (NSCLC). However, factors predicting patient subtypes that responsive PD-1/PD-L1inhibitors have not been fully understood yet. Biomarkers, like PD-L1 expression, tumor mutational burden(TMB), DNA mismatch repair deficiency (dMMR), and tumor-infiltrating lymphocytes (TILs), utilized...
Immunotherapy has become the first-line treatment for advanced non-small-cell lung cancer (NSCLC), but most patients still fail to benefit or have disease progression following treatment. M2 phenotype tumor-associated macrophages (M2-TAMs) are important cellular components in immunosuppressive microenvironment of NSCLC, how they contribute immunoresistance remains unclear. This study was conducted investigate role and mechanism M2-TAMs NSCLC immunoresistance.
Glucocorticoids (GC) are crucial in the treatment of rheumatoid arthritis (RA), but discontinuing GC effectively RA patients poses a significant challenge for rheumatologists.In this two-stage, single-center, non-randomized controlled trial, we investigated benefits combining Chinese traditional herbal with csDMARDs to aid discontinuation terms tapering, disease control, and safety.A total 231 participants were enrolled, which 150 eligible subjects included first phase allocated three groups...
To explore the prevalence and related risk factors of osteoporosis (OP) in elderly ≥60 years old Jiuting Town, Songjiang District, Shanghai City. A total 2 175 local residents aged who participated questionnaire survey at physical examination center Community Health Service Center, City from July 2021 to December 2022 were selected by a cross-sectional study with multi-stage sampling method. Questionnaire survey, blood test bone mineral density (BMD) conducted.The differences all parameters...
Osimertinib, the third generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, responds well to advanced non–small-cell lung cancer (NSCLC) with EGFR T790M mutation. However, resistance osimertinib would inevitably occur. We report a case an NSCLC patient after who was successfully treated by high-dose furmonertinib (AST2818) at 160 mg. The initially received GCP regimen for 11 months and displayed partial response. 80 mg time progression stable clinical...