A5027980238- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Genomic variations and chromosomal abnormalities
- Blood disorders and treatments
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Mesenchymal stem cell research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Childhood Cancer Survivors' Quality of Life
- Eosinophilic Disorders and Syndromes
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Prenatal Screening and Diagnostics
- Genetics and Neurodevelopmental Disorders
University of Padua
2008-2023
Azienda Ospedaliera di Padova
2007-2023
Istituto Giannina Gaslini
2016
Città della Speranza Foundation
2012
Ospedale San Bortolo
2009
Northwestern University
2009
Johns Hopkins University
2009
Heidelberg University
2009
Memorial Sloan Kettering Cancer Center
2009
Dalhousie University
2009
Abstract Pediatric acute lymphoblastic leukemia (ALL) comprises genetically distinct subtypes. However, 25% of cases still lack defined genetic hallmarks. To identify genomic aberrancies in childhood ALL patients nonclassifiable by conventional methods, we performed a single nucleotide polymorphisms (SNP) array‐based analysis leukemic cells from 29 cases. The vast majority analyzed (19/24, 79%) showed abnormalities; at least one them affected either genes involved cell cycle regulation or...
We report 2 intra-abdominal tumors originally diagnosed as leiomyosarcomas, occurring in adolescents, one a second malignancy after Hodgkin lymphoma. Both exhibited unusual morphologic features characterized by spindle cells arranged sheets or fascicles, devoid of the typical desmoplastic stroma. Cytokeratins and mesenchymal markers, including smooth muscle actin, desmin, specific were coexpressed tumor cells, whereas EMA was negative. Reverse transcription-polymerase chain reaction analysis...
// Salvatore Nicola Bertuccio 1 , Serravalle Annalisa Astolfi 1, 2 Lonetti Valentina Indio Anna Leszl 3 Andrea Pession and Fraia Melchionda Pediatric Hematology Oncology Unit, Department of Pediatrics, S.Orsola-Malpighi Hospital, University Bologna, Italy “Giorgio Prodi” Cancer Research Center, Woman Child Health, Laboratory Hematology-Oncology, Padova, Correspondence to: Melchionda, email: fraia.melchionda@aosp.bo.it Keywords: acute myeloid leukemia, monosomy chromosome 7,...
Abstract Background The diagnosis of myelodysplastic syndromes (MDS) is mainly based on morphology and cytogenetic analysis. Several efforts to analyze MDS by flow cytometry have been reported in adults. These studies focused the identification abnormalities maturation pathway antigen expression myelo‐monocytic cells, characterization blast populations. Therefore, phenotype has proposed as a diagnostic prognostic criterion tool for adult MDS. current article provides data concerning...
Abstract Familial platelet disorder with propensity to acute myelogenous leukemia, or FPD/AML (OMIM #601399), is a rare autosomal dominant condition, only 12 families reported. It characterized by qualitative and quantitative defects predisposition the development of myeloid malignancies. Causal mutations have been identified in RUNX1 gene (also known as AML1 , CBFA2 ) 11 so far analyzed. frequently involved pathogenesis sporadic leukemia myelodysplastic syndromes, through acquired...
Previous findings indicated that in vitro HTLV-I-infected cells are highly susceptible to spontaneous and chemically induced DNA-damage. To further study the role of different virus gene products inducing chromosome abnormalities, MOLT-3 were transiently transfected with a tax expressing plasmid (pTax), assayed for genetic damage by micronucleus test. We found pTax-transfected not only had statistically higher baseline value than non-transfected control cells, but also more Mitomycin C...
Abstract Background Hepatoblastoma (HB) is the most frequent malignant liver tumor in children. The few cytogenetic studies available indicate that HB associated with recurring trisomies of chromosomes 2, 8, and 20; recurrent t(1;4) (q12;q34) has been reported cases. abnormalities chromosome 1q are relatively usually lead to overexpression material. A cluster breakpoints located at level bands 1q12 1q21. More work needed clarify their real incidence prognostic significance. Cytogenetic...
Children with acute myeloid leukaemia (AML) harbouring CBF anomalies notoriously have a more favourable prognosis than other AML cytogenetic subgroups. In the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)-AML 2002/01 protocol, these patients were allocated to standard-risk (SR) group and all achieved morphological complete remission (CR) after induction therapy (Pession et al, 2013; Manara 2014). However, approximately one-third of them – in particular those...
Anaplastic large cell lymphoma (ALCL) constitutes approximately 15% of pediatric and 3% adult non-Hodgkin lymphomas. Most cases harbor the reciprocal translocation t(2;5)(p23;q35), involving alk gene. Cytogenetic studies ALCL have mostly been published as case-reports. The aim this study was to determine cytogenetic profiles a series compare them with from literature.Eighteen children treated at our Institution were studied by standard analysis RT-PCR for specific t(2;5) product. Comparative...