A5101819917- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Animal Genetics and Reproduction
- Assisted Reproductive Technology and Twin Pregnancy
- CRISPR and Genetic Engineering
- Photoreceptor and optogenetics research
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Molecular Communication and Nanonetworks
- Pluripotent Stem Cells Research
- Microtubule and mitosis dynamics
- Advanced Memory and Neural Computing
- Mesenchymal stem cell research
- Laser-Plasma Interactions and Diagnostics
- Effects of Environmental Stressors on Livestock
- Reproductive Physiology in Livestock
- Ovarian function and disorders
- Melanoma and MAPK Pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Genomics and Diagnostics
- Tissue Engineering and Regenerative Medicine
- High-pressure geophysics and materials
- Prenatal Screening and Diagnostics
Fudan University
2023-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2022-2024
Shanghai Institute of Technical Physics
2024
Chinese Academy of Sciences
2024
Ministère de l'Agriculture et de la Souveraineté alimentaire
2024
Ministry of Agriculture & Farmers Welfare
2024
Chinese Academy of Agricultural Sciences
2023-2024
State Key Laboratory of Animal Nutrition
2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2021-2023
Guangxi University
2018-2023
Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein repressive complexes 1 (PRC1), which participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 has been shown to have diverse, even opposite functions different types malignancy previous studies. In this study, we found that deletion promoted lung adenocarcinoma (LUAD) proliferation progression KrasG12D mutated background. vitro, over 50% Cbx4L/L, mouse embryonic...
Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder chicken production. The genetic basis of these traits, however, is far from understood, especially for broiler breeders. In this study, parameter estimation, genome-wide association analysis, meta-analysis, selective sweep analysis were carried out to identify loci associated with EW AFE 6,842 study found that the heritability ranged 0.42 0.44, while was estimated 0.33 maternal line. Meta-analysis...
Abstract Somatic cell nuclear transfer (SCNT) holds vast potential in agriculture. However, its applications are still limited by low efficiency. Histone 3 lysine 9 trimethylation (H3K9me3) was identified as an epigenetic barrier for this. demethylase KDM4D could regulate the level of H3K9me3. effects on buffalo SCNT embryos unclear. Thus, we performed this study to explore and underlying mechanism embryos. The results revealed that compared with IVF embryos, expression significantly lower...
Attempts to artificially activate unfertilized oocytes at 24 h post ICSI have generally resulted in poor outcomes. This study aims explore a new strategy for early judgement and rescue activation of 5 avoid unexpected fertilization failure or low cycles. In this study, we found that the average time Pb2 extrusion post-ICSI was 3.03±1.21 h, 95.54% had extruded before sensitivity specificity monitoring by time-lapse imaging predict were 99.59% 99.78%, respectively. Early with no acceptable...
The proliferation-quiescence decision is a dynamic process that remains incompletely understood. Live-cell imaging with fluorescent cell cycle sensors now allows us to visualize the dynamics of transitions and has revealed decisions can be highly heterogeneous, even among clonal lines in culture. Under normal culture conditions, cells often spontaneously enter non-cycling G0 states varying duration depth. This also occurs cancer entry tumors may underlie tumor dormancy issues recurrence....
The weight of breast muscle (WBM) is a highly monitored indicator in broiler breeding that can be obtained after slaughtering. Currently, due to the lack accurate vivo phenotypes for both genomic and phenotypic selection, genetic gains WBM fall short initial expectations. In this study, 1006 market-age (42 d) broilers from three generations over 2 years were randomly selected, width (BW), fossil bone length (FBL), thickness (BMT) live (LW) measured exactly vivo. Eight models, including...
Does short-interval second ejaculation improve sperm quality, embryo development and clinical outcomes for oligoasthenozoospermia males received intracytoplasmic injection (ICSI) treatment?All enrolled male patients underwent secondary on the day of oocyte retrieval, 786 sibling MII oocytes from 67 cycles were equally divided into two groups based whether injected spermatozoons originated first or ejaculation. Semen parameters, efficiency, morphokinetic parameters compared between to assess...
Contents Low efficiency of somatic cell nuclear transfer (SCNT) embryos is largely attributable to imperfect reprogramming the donor nucleus. The differences in epigenetic between female and male buffalo cloned remain unclear. We explored effects sex on development SCNT embryos. then compared expression DNA methylation (5‐methylcytosine‐5mC 5‐hydroxymethylcytosine‐5hmC) level relevant genes, histone (H3K9me2 H3K9me3) SCNT‐♀ SCNT‐♂ preimplantation with vitro fertilization (IVF) counterparts....
Granulosa cells (GCs) play a crucial role in follicular development and atresia. Previous studies have showed that GCs the form of monolayer influenced vitro maturation (IVM) oocytes. However, effects conditioned medium on IVM competence buffalo oocytes remain unclear. In present study, we examined impacts GC-conditioned (GCCM) GC efficiency embryo after parthenogenetic activation (PA). Our results GCCM was collected day 2 added to at 20% proportional level (2 days 20%) exerted significant...
Bone marrow-derived mesenchymal stem cells (BMSCs) from livestock are valuable resources for animal reproduction and veterinary therapeutics. Previous studies have shown that BMSCs were prone to malignant transformation of mesenchymal-to-epithelial transition in vitro, which can cause many barriers further application BMSCs. The transforming growth factor β (TGF-β) signaling pathway has been widely studied as the most important involved regulating features However, effects TGF-β on...
Abstract Animal cells within a tissue typically display striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown. We have previously shown size animal is promoted, part, by size-dependent regulation of G1 length. identify underlying process, we performed large-scale small molecule screen and found p38 MAPK pathway involved coordinating cell cycle progression. Small higher activity spend more time than larger cells. Inhibition leads...