A5077317575- Inflammatory Bowel Disease
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Essential Oils and Antimicrobial Activity
- Telemedicine and Telehealth Implementation
- Ethnobotanical and Medicinal Plants Studies
- COVID-19 Clinical Research Studies
- Enzyme Catalysis and Immobilization
- COVID-19 and healthcare impacts
- Psidium guajava Extracts and Applications
- Botanical Research and Applications
- Phytochemicals and Medicinal Plants
- Traditional and Medicinal Uses of Annonaceae
- Cancer Immunotherapy and Biomarkers
- Phytochemistry and biological activity of medicinal plants
- Gut microbiota and health
- Bee Products Chemical Analysis
- Immunodeficiency and Autoimmune Disorders
- Phytochemistry Medicinal Plant Applications
- Bioactive Natural Diterpenoids Research
- HIV/AIDS oral health manifestations
- Morinda citrifolia extract uses
- Single-cell and spatial transcriptomics
- Diverse Scientific Research Studies
- Protein Interaction Studies and Fluorescence Analysis
Casa Sollievo della Sofferenza
2020-2025
Hospital Roberto del Rio
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
Universidad Centroccidental Lisandro Alvarado
2018
Universidad de Ciencias Médicas de la Habana
2000-2013
Instituto de Nutricion e Higiene de los Alimentos
2012
Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear
2009
Universidad Complutense de Madrid
1997
Universitat de Barcelona
1997
University of Strathclyde
1993-1994
The pathogenesis of ulcerative colitis (UC) is unknown, although genetic loci and altered gut microbiota have been implicated. Up to a third patients with moderate severe UC require proctocolectomy ileal pouch ano-anastomosis (IPAA). We aimed explore the mucosal who underwent IPAA.For microbiome analysis, specimens were collected from 34 IPAA individuals. Endoscopic histological examinations normal in 21 cases, while pouchitis was 13 patients. 19 healthy control (10 colonic 9 ileum) also...
Growing evidence suggests that alterations in the gut microbiome impact development of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC). Although IBD often requires use immunosuppressant drugs biologic therapies to facilitate clinical remission mucosal healing, some patients do not benefit from these drugs, reasons for this remain poorly understood. Despite advancements, there is still a need develop biomarkers help predict prognosis guide...
A new technique with controlled interface generation allows separation and quantitation of enzyme inactivation by both solvent/aqueous dissolved solvent. This has now been used in n-butanol, isopropylether, 2-octanone, n-hexane, n-butylbenzene, n-tridecane. Ribonuclease was stable all the interfaces studied. Chymotrypsin mainly inactivated more hydrophobic interfaces, whereas lipase only less interfaces. Urease some but not all, without an obvious trend. Thus, commonly expected simple...
Aside from the outbreak of coronavirus disease 2019 (COVID-19), serological tests are not well known for their diagnostic value. We assessed performance using stored sera patients with a variety pathologic conditions, collected before 2020 pandemic in Italy.
Abstract Background Infliximab (IFX) biosimilars CT-P13 is available in a subcutaneous (SC) formulation. Both clinical trials and real life studies showed its effectiveness maintaining remission patients treated for several months of intravenous (IV) IFX. Although the current indications allow switch from IV to SC after two administrations, clinicians postpone achieving stable remission. What best time IFX unknown. This study aims evaluate endoscopic response, treatment persistence,...
Patients receiving biologic therapies are at risk for viral infections. This study investigated the impact of SARS-CoV-2 infection and serum prevalence antibodies in patients with inflammatory bowel disease (IBD) treated drugs.
Abstract Sesame seeds are an important source of edible oil and protein. Studies were made on protein solubility defatted sesame seed meal in aqueous solution over various pHs or salt solutions. Maximum was found alkaline solution, the proteins almost insoluble at acid solution. The NaCl CaCl 2 increased upon increasing concentrations up to 1 M. In Na SO 3 HPO 4 higher lower but decreased pH 8. Extractable separated into seven fractions electrophoretically (sodium dodecyl...
A method for immobilization-stabilization of thermolysin onto activated agarose gels is reported based on the formation covalent bonds between enzyme and support. All derivatives prepared retained 100% enzymatic activity they show higher stability than free thermolysin. The effect different variables concerning strength enzyme-support attachment immobilized has been established under inactivation conditions: presence a water miscible solvent (DMF); stirred biphasic systems, 1,...
Background: Immune checkpoint inhibitors (ICIs) have widened the therapeutic scenario of different solid tumors over last ten years. Gastrointestinal (GI) adverse events (AEs), such as diarrhea and colitis, occur in up to 50% patients treated with ICIs. Materials methods: We conducted a single-center retrospective analysis ICIs 6-year period, from 2015 2021, developing GI AEs, for which an endoscopic was performed, available histological specimens or surgery. Results: Twenty-one developed...
From September 2020, a second wave of COVID-19 pandemic started. We aimed at exploring the impact SARS-CoV-2 infection in IBD patients during two waves.All with confirmed diagnosis were enrolled. They sorted into groups (those infected before and those from 2020 to January 2021) compared by demographic clinical data.Twenty-five (out about 600 follow-up visit) (4.1%). Sixteen male mean age was 46.5 ± 14.3 years (range 24-74). Six smokers 11 had comorbidities; 2 on steroids 17...
Telemedicine (TM) has had a powerful impact in recent years, particularly on managing chronic diseases such as inflammatory bowel disease (IBD). Knowing patients' expectations and concerns is essential to increase their confidence this mode of medical care.We interviewed large cohort IBD patients enrolled at two Italian tertiary referral centers investigate trust TM.A total 376 completed the survey were included study: 293 (77.9%) considered TM valuable for disease, 307 (85%) wanted have...
In recent years, improvement of Health-Related Quality Life (HRQoL) in Ulcerative colitis (UC) has become a relevant measure for treatment efficacy.We report results from multicenter prospective study Italy investigating HRQoL adult patients with UC treated golimumab (GLM). Patients who had shown clinical response after 6-week induction phase (w0), were followed an additional 48 weeks (w48) (total 54-week treatment).Of the 159 enrolled 90 completed study. Compared to values at beginning (n =...
Abstract Background The administration of biologic drugs in inflammatory bowel diseases (IBD) is increasingly moving from intravenous to subcutaneous formulations. Limited data available on the effectiveness vedolizumab patients switching long-term therapy. aim study was evaluate efficacy and safety after ulcerative colitis corticosteroid-free clinical remission. Methods An observational, multicentre, prospective conducted by Italian Group for IBD Italy (IG-IBD). Ulcerative remission (pMAYO...
Aims & Objectives: Sepsis is a clinical syndrome characterized by fatal organ dysfunction. In adults, 6 echocardiographic phenotypes are identified that determine management and prognosis. We seek to extrapolate this classification the pediatric population. To describe of sepsis, estimating association with multiple dysfunction (Pediatric SOFA scale, P-Sofa), ICU mechanical ventilation (MV) free day Methods: Prospective observational study in 2 Pediatric Critical Patient Units Chile 2022 -...