A5025046711- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Parkinson's Disease Mechanisms and Treatments
- Hidradenitis Suppurativa and Treatments
- Inflammatory Bowel Disease
- Parathyroid Disorders and Treatments
- Microscopic Colitis
- Dermatology and Skin Diseases
- Colorectal and Anal Carcinomas
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hepatitis C virus research
- Rheumatoid Arthritis Research and Therapies
- Restless Legs Syndrome Research
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-related skin toxicity
- Autoimmune and Inflammatory Disorders Research
- Neurological disorders and treatments
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Systemic Lupus Erythematosus Research
- Pharmacological Effects and Toxicity Studies
- Eosinophilic Esophagitis
- HIV/AIDS drug development and treatment
- Family Support in Illness
- Dialysis and Renal Disease Management
ABB (Italy)
2013-2024
AbbVie (United States)
2014-2024
Marche Polytechnic University
2019
AbbVie (Japan)
2014
Objective. The purpose of the ULISSE study was to evaluate prevalence clinical and ultrasonographic (US) entheseal involvement in patients with psoriatic arthritis (PsA), psoriasis, fibromyalgia syndrome (FMS). Methods. In this cross-sectional multicenter study, PsA psoriasis (not taking systemic therapy) FMS underwent a evaluation entheses, B-mode power Doppler examination 6 pairs entheses. Results. analyzed 140 PsA, 51 FMS. Clinical US examinations were performed 1960 1680 entheses group,...
The GREENFIELD observational study assessed the effect of levodopa/carbidopa intestinal gel (LCIG) on motor and non-motor symptoms, related impact patient quality life caregiver burden up to 8 years. Final results a large Italian cohort patients who started LCIG in routine care between 2007 2014 are presented. Comparison baseline (before LCIG) follow-up visits yearly basis (visit 2/3) is reported. Primary endpoint was Unified Parkinson’s Disease Rating Scale (UPDRS-IV) Item 39; secondary...
Caring for a person with Parkinson's disease (PD) is associated an increased risk of psychiatric morbidity and persistent distress. The objective this study was to describe the burden related factors caregivers advanced PD (APD) patients either treated continuous dopaminergic delivery systems or standard therapy. This cross-sectional, epidemiologic conducted in 13 Italian sites enrolled delivering [either levodopa/carbidopa intestinal gel (LCIG) infusion subcutaneous apomorphine (CSAI)]...
Abstract Background Psoriasis can have cumulative physical and psychosocial effects preventing sufferers from achieving their full‐life potential. Few studies addressed the impact of psoriasis on work‐related characteristics. Objective To evaluate education prospects work limitations in patients with moderate‐to‐severe psoriasis. Methods This study was conducted 29 dermatology centres across Italy. Information collected by questionnaire during office visits. Results A total 787 (64% male,...
Abstract Background Hidradenitis suppurativa ( HS ) is a chronic, relapsing, inflammatory skin disease characterized by painful inflamed nodules, recurrent abscesses and fistulas located in apocrine gland–bearing body sites. The negative impact of on patient's quality life (QoL) has been reported to be greater than other dermatologic conditions as psoriasis atopic eczema, its improvement an important goal management. Nowadays, there are no specific validated QoL instruments available for...
<h2>Abstract</h2> The MARS-5 (Medication Adherence Report Scale) was developed in English. aim of this project to analyse the MARS-5I (© Prof Rob Horne) psychometric properties and identify whether its Italian translation is suitable for assessing medication adherence Crohn Disease (CD) patients. MARS translated linguistically validated Italian. used evaluating SOLE study, conducted Italy on 552 subjects with CD. In order un-bias questionnaire results from effects treatment change and/or...
Several levodopa/carbidopa intestinal gel (LCIG) studies showed a significant reduction of OFF time and increase ON time, as well dyskinesia, improvement non-motor symptoms quality life. However, few have been conducted in large population for more than 3 years. Interim outcomes from GREENFIELD observational study on Italian cohort advanced PD patients who started LCIG routine care between 2007 2014, still treatment at the enrollment, are presented. Comparison baseline (before start) visit 1...
Frequency of Advanced Parkinson's Disease (APD) and its clinical characteristics are still not well defined. Here, we aimed to assess APD prevalence in the Italian OBSERVE-PD cohort, as treatment eligibility device-aided therapies (DAT), compare judgment with established Delphi criteria.This sub-group analysis study was performed on patients enrolled by 9 Movement Disorders centers Italy. Motor non-motor symptoms, PD characteristics, activities daily living, quality life were assessed....
Depression in HIV/AIDS patients affects adherence and disease progression often goes unnoticed. DHIVA is a cross-sectional epidemiologic survey, investigating the prevalence of depression people living with HIV through use validated self-administered scale (CES-D-20), as well degree concordance between physician's perception patients' reports. A total 690 HIV-infected attending 24 centers across Italy were enrolled. Concordance was calculated by K statistics. Association subject...
<b><i>Background:</i></b> Mineral Bone Disorders (MBD) is prevalent in hemodialysis (HD) patients and associated with increased cardiovascular mortality. The FARO-2 study evaluated the achievement of NKF/K-DOQI guidelines on recommended target values for serum calcium (Ca), phosphorous (P) intact parathyroid hormone (PTH) levels survival incident HD patients. <b><i>Methods:</i></b> Data were collected by questionnaire from 568 followed...
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease that negatively impacts the quality of life and work productivity patients. Objectives: We sought to evaluate real-world burden AD patients in Italy. Methods: This sub-analysis MEASURE-AD multicountry study conducted between December 2019-2020 included diagnosed with moderate-to-severe eligible for receiving systemic therapy previous 6 months. During single visit, physician patient-reported questionnaires were used....
Abstract Objectives To characterize the effect of upadacitinib 15 mg once daily (UPA15) on enthesitis in patients with PsA from SELECT-PsA Phase 3 trials. Methods Patients an inadequate response/intolerance to one or more non-biologic DMARD (SELECT-PsA 1) biologic 2) received UPA15, adalimumab 40 every other week placebo (weeks 0–24) switched UPA15 (week 24 onward). The Leeds Enthesitis Index (LEI) and Spondyloarthritis Research Consortium Canada (SPARCC) index were used assess improvement...
Abstract Background The Psodisk is a 10‐item visual instrument, aimed at measuring the burden of psoriasis on patients. Objectives To validate in large sample patients with psoriasis, and to define categories for interpretation scores. Methods Data were collected 21 dermatological centres. was administered baseline (t0), after 2 or 3 days (t1) about months (t2) baseline, data used assess validity reliability instrument. cut‐off scores determined using perception severity disease by patient...
Abstract Background Hidradenitis suppurativa (HS) is a chronic, debilitating disease with considerable effect on patient quality of life. Its clinical severity can be measured using different scoring systems; however, few them include patient‐centred parameters. Objective To create new system for HS that includes quality‐of‐life instrument, the HIDRAdisk. Methods This post hoc analysis was carried out within framework multicentre, longitudinal, epidemiologic study conducted over 9 months...
<b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually occurs after puberty with painful, deep-seated, inflamed nodules and sinus tracts in apocrine gland-bearing areas body, most commonly axillae inguinal anogenital regions, relevant impact on patients’ quality life (QoL). <b><i>Objective:</i></b> To evaluate how burden HS impacts patient...
Mortality rate among patients with stage five chronic kidney disease (CKD) maintained on hemodialysis (HD) is high. Although evidence suggests that use of Vitamin D Receptor Activators (VDRA) in CKD increases survival, few studies have examined the effect VDRA incident HD patients. The FARO-2 study evaluated clinical outcome therapy mortality was a longitudinal epidemiological performed 568 followed prospectively from 26 dialysis centers over 3-year period. Data were collected every 6 months...
Abstract Chronic lymphocytic leukemia (CLL) therapies differ in efficacy, side effects, route, frequency, and duration of administration. We assessed patient preferences for treatment attributes evaluated associations with disease stage, line, socio‐demographic characteristics a cross sectional, observational study conducted at 16 Italian hematology centers. Study visits occurred between February July 2020; 401 adult patients CLL (201 Watch Wait (W&W), 200 treated) participated discrete...
International Guidelines for mineral bone disorders recommend that in Non Dialytic-Chronic Kidney Disease (ND-CKD) clinical decisions should be based on the trend of serum PTH changes over time rather than a single value. However, prognostic impact these ND-CKD patients remains unknown. We performed multicenter cohort study (stage 1-5) followed 36 months 24 Italian Nephrology Units. (ΔPTH) were defined as absolute differences between all available measurements following first control and...
The aim of this study was to assess the burden and quality life (QoL) perceived by caregivers assisting advanced Parkinson's disease (PD) patients.Consecutive PD patients treated with levodopa/carbidopa intestinal gel (LCIG) or continuous subcutaneous apomorphine infusion (CSAI) care as usual (CU) their partners were recruited during routine visits according a cross-sectional design. Caregiver's distress assessed Zarit Burden Interview (ZBI) QoL survey evaluate understand experienced family...