A5027478875- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Restless Legs Syndrome Research
- Adenosine and Purinergic Signaling
- Polymer Surface Interaction Studies
- Reproductive System and Pregnancy
- Immune cells in cancer
- Apelin-related biomedical research
- Cytomegalovirus and herpesvirus research
- Hepatitis B Virus Studies
- Pickering emulsions and particle stabilization
- Liver Disease Diagnosis and Treatment
- Full-Duplex Wireless Communications
- Energy Harvesting in Wireless Networks
Inserm
2013-2025
Institut de Transplantation Urologie en Nephrologie
2013-2025
Center for Research in Transplantation and Translational Immunology
2016-2025
Nantes Université
2013-2024
Hôpital Saint-Louis
2017
Le Mans Université
2016
Université Nantes Angers Le Mans
2016
Centre Hospitalier Universitaire de Nantes
2013
Abstract Autoimmune liver diseases (AILD) involve dysregulated CD4 T cell responses against self-antigens, but how these autoreactive cells relate to tissue pathology remains unclear. Here we perform single-cell transcriptomic and receptor analyses of circulating, self-antigen-specific from patients with AILD identify a subset liver-autoreactive distinct B-helper transcriptional profile characterized by PD-1, TIGIT HLA-DR expression. These share clonal relationships expanded intrahepatic...
MICA are major histocompatibility complex class I-related molecules, expressed by endothelial cells (ECs), that may be targets for alloantibodies and NKG2D-expressing natural killer (NK) T effector in organ allografts. This study shows basal levels of on vascular ECs is sufficient to functionally modulate the expression activity immunoreceptor NKG2D allogeneic NK cells. We found differentially regulated at EC surface response cytokines. TNFa upregulates while IFNγ significantly...
Among innate cells, natural killer (NK) cells play a crucial role in the defense against cytomegalovirus (CMV). In some individuals, CMV infection induces expansion of NKG2C<sup>+</sup> NK that persist after control infection. We have previously shown KIR2DL<sup>+</sup> contrast to contribute controlling using CMV-infected monocyte-derived dendritic cell (MDDC) model. However, nature contributing subset remains unclear. To gain more insight into this question, we...
Natural Killer (NK) cells are potent anti-tumor effectors, involved in hematological malignancies and solid tumor immunosurveillance. They infiltrate various tumors their numbers correlated with good outcome. The function of NK extended lytic capacities towards expressing stress induced ligands, through secretion immunoregulatory cytokines, interactions other immune cells. Altered cell due to escape is frequent advanced tumors, however, strategies release the infiltrating emerging. Recent...
BK polyomavirus (BKPyV) frequently reactivates in kidney transplant recipients during immunosuppressive therapy and triggers BKPyV-associated nephropathy graft rejection. Determining effective risk factors for BKPyV reactivation is required to achieve efficient prevention.This study investigated the role of major histocompatibility complex (MHC) class I-related chain A (MICA) a cohort 144 donor/recipient pairs, including with no (controllers) those mild (virurics) or severe (viremics) after...
Abstract MHC class I chain–related proteins A and B (MICA MICB) UL16-binding are ligands of the activating NKG2D receptor involved in cancer immune surveillance infection. Structurally, MICA/B contain an α3 domain, whereas do not. We identified novel alternative splice transcripts for MICA encoding five isoforms: MICA-A, -B1, -B2, -C, -D. Alternative splicing associates with MICA*015 *017 results from a point deletion (G) 5′ donor site intron 4 leading to exon 3 skipping and/or deletions....
Abstract Autoimmune liver diseases (AILD) are immune-mediated disorders in which CD4 T cells play a central role. However, the link between circulating self-antigen-specific and targeted tissue has not been extensively studied AILD. We hypothesized that autoreactive were clonally functionally related to dominant intra-hepatic pathogenic cell clones. Single transcriptomic analysis of revealed specific B-helper immuno-exhausted transcriptional profile, was conserved for different autoantigens,...
Relapse after immunosuppression (IS) treatment withdrawal is frequent in patients with Autoimmune Hepatitis (AIH), and non-invasive biomarkers predictive of this risk are lacking. We assessed the frequency circulating T cell subsets as potential disease activity predictor relapse IS withdrawal. Serum levels cytokine B-cell Activating Factor (BAFF) were also investigated. Blood samples from 58 active AIH, 56 AIH remission, 31 NASH analyzed. The activated CD4+ peripheral helper (TPH) cells...