A5023626580- Pituitary Gland Disorders and Treatments
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Diet and metabolism studies
- Diabetes and associated disorders
- GDF15 and Related Biomarkers
- Adrenal Hormones and Disorders
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Failure Treatment and Management
- Stress Responses and Cortisol
- Ophthalmology and Eye Disorders
- Nutrition and Health in Aging
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Neuroendocrine Tumor Research Advances
- Glycogen Storage Diseases and Myoclonus
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Adrenal and Paraganglionic Tumors
Medical University of Vienna
2011-2024
Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics
2023
University of Vienna
1995-2021
University Hospital Regensburg
2020
Johannes Gutenberg University Mainz
2015-2019
University of Minnesota System
2019
University Medical Center of the Johannes Gutenberg University Mainz
2015-2018
Park Terrace Care Center
2006
Vienna General Hospital
1995-2006
Institute of Endocrinology
1994
Oxytocin is a hormone and neurotransmitter found to have anti-inflammatory functions in rodents. Here we used experimental bacterial endotoxinemia examine the role of exogenous oxytocin administration on innate immune responses humans. Ten healthy men received, randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, LPS + oxytocin. treatment resulted transient or prolonged reduction endotoxin-induced increases plasma ACTH, cortisol, procalcitonin, TNF-α, IL-1 receptor...
BACKGROUND Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine linked to obesity comorbidities such as cardiovascular disease, inflammation, and cancer. GDF-15 also has adipokine properties recently emerged prognostic biomarker for events. METHODS We evaluated the relationship of plasma concentrations with parameters obesity, glucose lipid metabolism in cohort 118 morbidly obese patients [mean (SD) age 37.2 (12) years, 89 females, 29 males] 30 age- sex-matched healthy...
Patients with type 1 diabetes mellitus (DM1) have to be active participants in their treatment because they are inevitably responsible for own day-to-day-care. Availability of mobile Internet access is advancing rapidly and phones now widely available at low cost. Thus, the potential assist daily management enable a telemedical interaction between patients health care professionals.The aim study was evaluate feasibility user acceptance phone-based data service DM1 on intensive insulin...
Hormonal dysfunction involving the hypothalamic-pituitary-adrenal (HPA) axis, prolactin (PRL) secretion and sex hormone status has been supposed to contribute development or persistence of rheumatoid arthritis (RA). In addition, a reduced number glucocorticoid receptors on circulating lymphocytes found in patients with RA. However, so far most studies have performed pre-treated patients. A combined test for total anterior pituitary reserve was 10 newly diagnosed untreated Before after...
Context: Ghrelin is a gut hormone with highly preserved biological activity, which seems not to be restricted the regulation of food intake, body composition, and growth. Continuous research unraveling new properties ghrelin, among others cardiovascular antiinflammatory activities. recently implicated in host response bacterial endotoxin rodents suggested as possible therapeutic tool sepsis. Objective: This study aimed investigate plasma ghrelin levels during human endotoxemia. Design...
Osteopontin (OPN) is a multifunctional protein involved in bone metabolism, cardiovascular disease, diabetes, and obesity. OPN levels are elevated the plasma adipose tissue of obese subjects, decreased with diet-induced weight loss.We investigated effect bariatric surgery on concentrations morbidly patients.The study was performed at university hospital.We 40 patients aged 43.1 +/- 1.8 yr, scheduled to undergo surgery. Roux-en-Y gastric bypass (RYGB) 30 subjects (27 females, three males),...
Circulating levels of B-type natriuretic peptide (BNP) and NH 2 -terminal-proBNP (NT-proBNP) increase in response to volume overload help the differential diagnosis acute heart failure. Elevated plasma BNP are observed also sepsis do not always correspond left ventricular dysfunction. Here, we investigated NT-proBNP fluctuations human bacterial endotoxinemia, an experimental model systemic infection inflammation. Escherichia coli endotoxin (LPS) (2 ng/kg) was administered 10 healthy...
Objective Growth differentiation factor 15 (GDF15) is a cardiovascular biomarker belonging to the transforming growth factor-β superfamily. Increased GDF15 concentrations are associated with insulin resistance, diabetes and obesity. We investigated physiological effects of meal composition obesity on regulation systemic levels. Design Lean ( n = 8) obese individuals received carbohydrate- or fat-rich meal, 75 g oral glucose load (OGTT) short-term fasting. OGTTs were performed in severely...
Abstract Context Supplemental selenium (Se) may affect the clinical course of Graves disease (GD). Objective Evaluate efficacy add-on Se on medical treatment in GD. Design Double-blind, placebo-controlled, randomized supplementation trial. Setting Academic endocrine outpatient clinic. Patients Seventy untreated hyperthyroid patients with Intervention Additionally to methimazole (MMI), received for 24 weeks either sodium selenite 300 µg/d po or placebo. MMI was discontinued at euthyroid...
To analyze whether medical care is in accordance with guidelines for secondary prevention of myocardial infarction (MI), or stroke patients type 2 diabetes from Germany and Austria. 29,325 (≥20 years age) MI, stroke, documented between 2006 2015 were selected the Diabetes-Patienten-Verlaufsdokumentation database. We analyzed medication, clinical characteristics, lifestyle factors according to national separately. HbA1C <7.5 % was achieved 64.9 61.1 (stroke) patients. LDL <100 mg/dl 56.2 42.2...
To evaluate the efficacy of fluconazole as an alternative treatment for controlling hypercortisolism in Cushing's syndrome and to determine its effect on glucocorticoid production vitro.Case report vitro study a University Clinic.An 83 year old patient presented with recurrence due pulmonary metastases three years after unilateral adrenalectomy. During near fatal episode sepsis she was started 200 mg/day intravenously which normalised cortisol excretion. The therapy continued orally 18...
Adrenomedullin (ADM) is a vasoactive peptide found to be related obesity and its comorbidities: type 2 diabetes, hypertension, atherosclerosis, coronary heart disease. ADM increased both in plasma adipose tissue of obese individuals when compared lean subjects considered as member the adipokine family. We determined midregional proadrenomedullin (MR-proADM) concentrations cohort 357 with BMI ranging from 17.5 42.3 kg/m2 no additional medical history. In parallel, 28 severely patients...
Hyperuricemia is a risk factor for cardiovascular events and renal insufficiency. It correlates to intima-media thickness microalbuminuria. In this study we evaluated uric acid as an independent marker cardiac in patients with diabetes.In prospective observational recruited 494 diabetes. Patients were then followed 12.8 months (mean follow-up) hospitalizations result of (ischaemic heart disease, arrhythmias, failure) recorded.The median duration diabetes was 11 ± 10.35 years. the mean 60 13...
Ghrelin and peptide YY (PYY) are both hormones derived from the gastrointestinal tract involved in appetite regulation. The cholinergic part of vagal nerve is regulation glucose insulin. aim this study was to examine effects antagonist atropine on ghrelin, PYY, glucose, insulin under basal conditions after meal ingestion lean obese subjects.Eight eight subjects were included a randomized, double-blind, placebo-controlled crossover with 4 days randomized order (atropine/placebo +/-...
Oxytocin (OXT) and ghrelin have several common properties such as the involvement in first phase response to stressors, appetite regulation, modulation of neural functions. Despite a recent study showing that intraventricular administration activates OXT neurons, little is known on cross-talk between these two peptides. Here, we investigated role i.v. circulating concentrations under fasting conditions during lipopolysaccharide (LPS)-induced endotoxemia. A randomized placebo-controlled...
Aims To assess the prevalence of elevated liver enzymes in adults with type 1 diabetes mellitus ( T1DM ) routine clinical care and association cardiovascular risk profile D iabetes‐ P rospective‐ ocumentation DPV network G ermany A ustria. Subjects methods This cross sectional observational study from registry includes data 45 519 at 478 centres up to S eptember 2016. Liver enzyme measurements were available 9226 (29%) patients 270 analysed for increased alanine aminotransferase ALT ; men...