Fernando Antônio Botoni
A5011227218- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Parasites and Host Interactions
- Long-Term Effects of COVID-19
- Parasitic Diseases Research and Treatment
- Intraocular Surgery and Lenses
- Iron Metabolism and Disorders
- Machine Learning in Healthcare
- Cardiac Arrest and Resuscitation
- COVID-19 diagnosis using AI
- Research on Leishmaniasis Studies
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Kidney Injury Research
- Cardiovascular Effects of Exercise
- Intensive Care Unit Cognitive Disorders
- Erythropoietin and Anemia Treatment
- Venous Thromboembolism Diagnosis and Management
Universidade Federal de Minas Gerais
2013-2024
Fundação Hospitalar do Estado de Minas Gerais
2013-2024
Universidade de Brasília
2021
Pontifícia Universidade Católica de Minas Gerais
2019
Hospital das Clínicas da Universidade Federal de Minas Gerais
2005-2019
Hospital Risoleta Tolentino Neves
2011-2018
Hospital Sírio-Libanês
2017
Brazilian Research in Intensive Care Network
2017
Latin American Sepsis Institute
2017
European Society of Intensive Care Medicine
2013
To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals.A cohort study laboratory-confirmed who were hospitalized from March 2020 September in 25 hospitals. Data collected medical records using Research Electronic Capture (REDCap) tools. A multivariate Poisson regression model was used assess risk factors for mortality.For a total 2,054 (52.6% male; median age 58 years), mortality 22.0%;...
We sought to evaluate whether procalcitonin was superior C-reactive protein in guiding antibiotic therapy intensive care patients with sepsis.Randomized open clinical trial.Two university hospitals Brazil.Patients severe sepsis or septic shock.Patients were randomized two groups: the group and group. Antibiotic discontinued following a protocol based on serum levels of these markers, according allocation The considered if duration at least 25% shorter than For both groups, seven full-days...
Succinate is an intermediate of the citric acid cycle as well extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such ischemia increase succinate blood levels, we investigated role this metabolite during a heart ischemic event, using human rodent models. We found that causes cardiac hypertrophy GPR91 dependent manner. activation triggers...
To develop a document by Brazilian Cardiovascular Imaging Department (DIC) and the European Association of (EACVI) to review summarize most recent evidences about non-invasive assessment patients with Chagas disease, intent set up framework for standardized cardiovascular imaging assess morphologic functional disturbances, as well guide subsequent process clinical decision-making.Chagas disease remains one prevalent infectious diseases in Latin America, has become health problem non-endemic...
Patients hospitalized in the Intensive Care Unit (ICU) may present risk for corneal injury due to sedation or coma. This study aimed estimate incidence of injuries; identify factors and propose a prediction model development injury, adult patients, an intensive care unit public hospital. is one year, prospective cohort with 254 patients. The data were analyzed using descriptive statistics, univariate logistic regression. Of 59.4% had injuries mean time onset was 8.9 days. independent...
: Hospitalized patients require the use of a variety drugs, many which individually or in combination have potential to cause kidney damage. The potentially nephrotoxic drugs is often unavoidable, and need for dose adjustment should be evaluated. This study aimed at assessing concordance information on drug-induced nephrotoxicity recommendations by comparing four drug sources (DRUGDEX®, UpToDate®, Medscape® Brazilian Therapeutic Formulary) using formulary public hospital. A total 218 were...
Abstract Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was assess clinical characteristics in-hospital outcomes of patients with COVID-19, compare it non-CD patients. Consecutive confirmed were included from March September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus hospital performed 4:1 ratio. Of 7018 who had 31 124 matched controls (median age 72 (64–80)...
Abstract The majority of early prediction scores and methods to predict COVID-19 mortality are bound by methodological flaws technological limitations (e.g., the use a single model). Our aim is provide thorough comparative study that tackles those issues, considering multiple techniques build models, including modern machine learning (neural) algorithms traditional statistical techniques, as well meta-learning (ensemble) approaches. This used dataset from multicenter cohort 10,897 adult...
Introduction Schistosomiasis (SM) is a parasitic disease caused by Schistosoma mansoni . SM causes chronic inflammation induced eggs, with collagen/fibrosis deposition in the granuloma process liver, spleen, central nervous system, kidneys, and lungs. Pulmonary arterial hypertension (PAH) clinical manifestation characterized high pressure pulmonary circulation right ventricular overload. This study investigated production of functional autoantibodies (fAABs) against second loop...
AimsChagas disease patients often present premature ventricular complexes (PVCs), depression of left ejection fraction (LVEF) and autonomic dysfunction, which is generally evaluated by heart rate variability (HRV) analysis. As frequent PVCs may complicate HRV computation, we measured turbulence (HRT) the correlation between HRT or in Chagas disease.
Cardiomyopathy is the most important manifestation of Chagas' disease. Brain natriuretic peptide (BNP) level and Doppler echocardiographic parameters for diastolic dysfunction have shown correlation with left ventricle (LV) filling pressures.The purpose this study to compare BNP levels in patients chagasic cardiomyopathy.Forty-three (69.8% men; mean age 41.0 +/- 10.4 years) were submitted an 39 had their measured.BNP increased deterioration function (P=0.025). Pulmonary venous flow...
The purpose of this study is to describe a technical modification percutaneous tracheostomy that combines principles the Percu Twist™ and Griggs-Portex® methods in reusable kit. One hundred patients underwent procedure. There were no false passage, tube misplacement, or deaths related two minor bleedings managed conservatively. described safe simple execute.
Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death admittance to the intensive care unit (ICU). Failure identify patients at high risk developing septic shock contributes an increase burden rapid molecular tests are currently most promising avenue aid patient determination therapeutic anticipation. The primary goal this study was evaluate genetic susceptibility that affects outcome 72 admitted ICU. Seven polymorphisms were genotyped key...
FUNDAMENTO: O índice de Tei avalia simultaneamente as funções sistólica e diastólica dos ventrículos. Apresenta boa correlação com dados hemodinâmicos tem sido capaz detectar alterações na função ventricular iniciais diversas etiologias. OBJETIVO: Estudar da biventricular em pacientes chagásicos sem cardiopatia aparente por meio do Tei. MÉTODOS: Foram avaliados 48 indivíduos. Grupo 1, constituído 25 diagnóstico doença Chagas, ecocardiograma normal; grupo 2, 23 indivíduos sadios sorologia...
Atrial function is an important component in overall cardiovascular performance. However, information on atrial dilated cardiomyopathy limited. This study aimed to assess and investigate if parameters of are more impaired Chagas (CDC) than idiopathic (IDC). Seventy-two patients with (36 CDC 36 IDC) 32 healthy controls were evaluated by tissue Doppler, Doppler-based strain rate (SR) imaging the left atrium (LA) right (RA). Peak during systole SR systole, early late diastolic SR, measured at...
OBJECTIVES: During the 2009 influenza A H1N1 pandemic, it became difficult to differentiate viral infections from other conditions in patients admitted intensive care unit.We sought evaluate behavior and diagnostic utility of procalcitonin, C-reactive protein four molecules with suspected Influenza infection. METHODS:The serum levels protein, tumor necrosis factor a, interferon c, interleukin 1b, 10 were tested on admission days 3, 5, 7 35 infection who two ICUs. RESULTS:Twelve had confirmed...
The COVID-19 pandemic caused unprecedented pressure over health care systems worldwide. Hospital-level data that may influence the prognosis in patients still needs to be better investigated. Therefore, this study analyzed regional socioeconomic, hospital, and intensive units (ICU) characteristics associated with in-hospital mortality admitted Brazilian institutions. This multicenter retrospective cohort is part of Registry. We enrolled ≥ 18 years old laboratory-confirmed participating...