A5101765416- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Biomedical Research and Pathophysiology
- Boron and Carbon Nanomaterials Research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Diet and metabolism studies
- Nanoparticles: synthesis and applications
- Hedgehog Signaling Pathway Studies
- Graphene and Nanomaterials Applications
- Kruppel-like factors research
- Cancer-related gene regulation
- Kidney Stones and Urolithiasis Treatments
- Ferroptosis and cancer prognosis
- Tumors and Oncological Cases
Hubei University of Medicine
2025
Taihe Hospital
2025
Tianjin Medical University
2016-2025
Second Hospital of Tianjin Medical University
2016-2025
Albert Einstein College of Medicine
2016
Montefiore Medical Center
2016
The Bronx Defenders
2014
University of Oxford
2013
University of Chicago
2009-2010
Cancer-associated fibroblasts (CAFs) are found in primary and advanced tumours. They primarily involved tumour progression through complex mechanisms with other types of cells the microenvironment. However, essential fibroblasts-related genes (FRG) bladder cancer still need to be explored, there is a shortage an ideal predictive model or molecular subtype for immune therapeutic assessment cancer, especially muscular-invasive based on FRG.
As an antibody-drug conjugate (ADC), disitamab vedotin (RC48) is a promising treatment targeting ERBB2 for locally advanced and metastatic bladder cancer (BLCA). However, the subtype heterogeneity of muscle-invasive (MIBC) often leads to different therapeutic outcomes. In our study, we aim explore sensitivity differences mechanisms molecular subtypes MIBC RC48 develop strategy combination therapy against cancer. Using large-scale mRNA expression profile datasets, Western blotting,...
Zinc oxide nanoparticles (nZnO) have been widely used in the medicine field. Numerous mechanistic studies for nZnO's anticancer effects are merely performed under high concentration exposure. However, possible mechanisms of epigenetic dysregulation induced by low doses nZnO unclear.nZnO were characterized and bladder cancer T24 cells treated with 48 hrs at different exposure concentrations. Cell cycle, apoptosis, cell migration invasion determined. We qRT-PCR, Western blot chromatin...
The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of migration, invasiveness, and metastasis traits. During tumor progression, EMT can be induced by transforming growth factor-β (TGF-β) signal that epithelial cells receive from their microenvironment. However, master regulatory controls on TGF-β-EMT axis are not understood.The protein expression in human specimens was measured immunohistochemical staining. E74-like factor 5 (Elf5) silenced short interfering...
Oxidative stress is a causal factor and key promoter of urolithiasis associated with renal tubular epithelium cell injury. The present study was designed to investigate the preventive effects metformin on injury induced by oxalate stone formation in hyperoxaluric rat model. MTT assays were carried out determine protection from oxalate‐induced cytotoxicity. intracellular superoxide dismutase (SOD) activities malondialdehyde (MDA) levels measured vitro. Male Sprague‐Dawley rats divided into...
BACKGROUND Pim-3 kinase is a highly homologous serine/threonine that overexpressed in hematological malignancies and solid tumors. Few studies have been conducted to define the role of tumors, especially prostate cancer. The aim this study was development prognosis MATERIAL AND METHODS We collected specimens from 160 patients with cancer, as well 100 benign prostatic hyperplasia. Realtime polymerase chain reaction used for assessment expression at RNA level Western blot quantify protein...
Ribosomal stress is known to increase cancer risk; however, the molecular mechanism underlying its various effects on remains unclear. To decipher this puzzle, we investigated upstream signaling pathway that might be involved in promoting ribosomal leads tumor progression. Our results suggested inhibition of kinase PIM1 attenuated PC3 cell growth and motility following condensed cellular body decreased protein translation PIM1-inhibited cells. In addition, was found a component small 40S...
Along with the increasing production and application of graphene oxide (GO), its environmental health safety (EHS) risks have become a global concern. Numerous studies investigated biosafety toxicity mechanisms associated GO, however, majority previous were based on direct toxic dose, which could not reflect realistic state exposure GO an indirect dose (low dose). Meanwhile, effects low-dose progression tumors are still unclearly. Herein, we found that can promote multiple types tumor cell...
Although we and other studies indicated ZNF217 expression was increased in prostate cancer (PCa), the factors mediating its misregulated their oncogenic activity remain largely unexplored. Recent evidence demonstrated that ferroportin (FPN) reduction lead to decreased iron export intercellular consequently aggravates effects of iron. In present study, identified as a transcriptional repressor inhibits FPN expression. Increased led concentration, coupled with resultant intracellular...
The objective of this study was to evaluate the protein level glypican-5 (GPC5) and its relationship with clinicopathologic significance in prostate cancer. GPC5 160 cancer tissues 60 adjacent normal samples examined by immunohistochemistry analysis, results were correlated parameters. markedly lower than that cases, especially high-risk Additionally, low expression closely associated increased serum prostate-specific antigen (PSA), higher Gleason scores, advanced tumor stage (T3), positive...
Abstract Background With the popularity of serum prostate‐specific antigen (PSA) screening, number newly diagnosed prostate cancer (PCa) patients is increasing. However, indolent and invasive PCa cannot be distinguished by PSA level. Here, we mainly explored role heterogeneous nuclear ribonucleoprotein M (hnRNPM) in invasiveness PCa. Methods Reverse‐transcription quantitative polymerase chain reaction Western blotting were used to detect expression hnRNPM benign hyperplasia (BPH) tissue...
The primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At present, PC has been found to be deficiency or loss in multiple cancers. Restoring could novel targeting therapy strategy. Our research showed that was reduced human bladder cancer (BLCA) cells, promotes cell proliferation. However, concrete mechanisms remain unknown. SCL/TAL1 interrupting locus (STIL), PC-related protein, screened our previous study...
The incidence and prevalence of urinary stone are increasing throughout the world. Compared to past, recent demographics patient with urolithiasis compositions strikingly different. Furthermore, clinical studies implied that seasonal cyclicity might influence distribution composition.We sought determine trends in pathogenesis based on analyses. Between 2002 2014, a total 2,383 eligible samples from different patients were collected our center. Infrared spectroscopy was used for calculi...
SCL/TAL1 Interrupting locus (STIL) is a ciliary-related gene involved in regulating the cell cycle and duplication of centrioles dividing cells. STIL has been found disordered multiple cancers driven carcinogenesis. However, molecular mechanisms biological functions remain ambiguous. Here, we systematically analyzed genetic alterations, mechanisms, clinical relevance across >10,000 samples representing 33 cancer types The Cancer Genome Atlas (TCGA) dataset. We that expression...