A5078298760- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Oral Health Pathology and Treatment
- Tumors and Oncological Cases
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Cerebral Venous Sinus Thrombosis
- Brain Metastases and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Hearing, Cochlea, Tinnitus, Genetics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Salivary Gland Tumors Diagnosis and Treatment
- Vestibular and auditory disorders
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ear Surgery and Otitis Media
- Mesenchymal stem cell research
- Colorectal and Anal Carcinomas
Copenhagen University Hospital
2019-2024
Rigshospitalet
2018-2024
University of Copenhagen
2018-2024
Novo Nordisk Foundation
2024
Regional Hospital West Jutland
2021
Aarhus University
2020
Regional Hospital Holstebro
2020
Vrije Universiteit Amsterdam
2020
University Hospital of Geneva
2020
University of Padua
2020
There are examples of incongruence between the WHO grade and clinical course in meningioma patients. This recurrence has led to search for other prognostic histological markers.To study correlation Ki-67 proliferative index (PI), risk recurrence, rates patients.We prospectively collected pathological diagnosis de novo consecutive meningiomas. In total, we followed 159 patients with controls until death, or emigration. We estimated PI when adjusted age at diagnosis, sex, grade, extent...
TERT promoter mutation (TERTpMut ) has a strong association to recurrence and been suggested act as driver for malignant transformation of WHO grade I II meningiomas. TERTpMut investigated in selected high-grade meningioma samples. The existence across recurrent tumors population-based cohort needs be order identify when emerges samples validate prognostic impact among III tumors.We gathered material from consecutive single-center 40 patients with (WHO III) treated between 2000 2018,...
Thyroid cancer constitutes a major and increasing proportion of head neck cancers in children adolescents. The purpose this study was to determine the incidence survival thyroid Danish patients aged 0-24 years from 1980 2014.Patients registered with primary Cancer Registry or Pathology Data Bank during 1980-2014 were included. Crude rates age-adjusted (AAIR) per 100,000, average annual percent change (AAPC), overall (OS) evaluated relation sex, histopathological tumor type, age at diagnosis,...
OBJECTIVE Meningioma is the most common primary intracranial neoplasm. Only 1%–3% of meningiomas are malignant according to 2016 WHO criteria (WHO grade III). High-grade present specific gene expression signatures indicating aggressive growth or recurrence. However, changes in and neuroinflammatory III during progression from I II unknown. METHODS The authors used a NanoString targeted panel with focus on 787 genes relevant meningioma pathology pathways investigate patients treated at...
The cerebrospinal fluid (CSF) is a key matrix for discovery of biomarkers relevant prognosis and the development therapeutic targets in pediatric central nervous system malignancies. However, wide range protein concentrations age-related differences children makes such discoveries challenging. In addition, CSF samples are often sparse first prioritized clinical purposes. present work focused on optimizing each step proteome analysis workflow to extract most detailed information possible from...
Objective: The aim was to establish a large comprehensive database of patients with oral cavity squamous cell carcinoma (OSCC) enable surveillance and research the disease.Methods: All diagnosed and/or treated for OSCC at Rigshospitalet, University Copenhagen, Denmark in period 2000-2014 were included.Rigshospitalet is tertiary treatment center covers Eastern region, comprising nearly half approximately 5.8 million inhabitants Denmark.Data on numerous variables regarding general information...
OBJECTIVE WHO grade III meningiomas, also known as malignant meningiomas (MMs), are rare, and the heterogenous clinical course in patients with MM is not well described. To characterize of MM, granular data were gathered from 51 treated at Department Neurosurgery Radiation Oncology, Rigshospitalet, Copenhagen, Denmark, between 2000 2020. METHODS The authors investigated outcome timing terms 1) tumor progression transformation previously diagnosed I or II (patients a secondary [sMM]); 2)...
Abstract Background Pediatric head and neck malignancies are rare only a few descriptive epidemiological studies have been published. Using unique nationwide registries, we report age‐specific incidence rates of cancer (HNC) among children during four decades. Methods Data were obtained from the Danish Cancer Registry. We included aged 0–14 years diagnosed between January 1, 1978 December 31, 2014 with extra‐orbital, nonskin nonbone HNC. Patients divided into nine groups in regard to tumor...
TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level based TERTp-mut status. Implementation into WHO grading led prognostication by improved prediction recurrence. Our results support implementation diagnostics and meningiomas.
Abstract Background The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided using Aalen-Johansen method, which a direct extension that accounts for events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting analysis. extent to events considered meningioma literature unknown, consequences incorrect methodologies analysis not been...
Abstract Meningiomas are the most common primary intracranial tumors and show extensive infiltration of macrophages. The mitochondrial membrane protein translocator (TSPO) has been used as an in vivo marker microglia macrophage activation to visualize neuroinflammation. However, it is unknown which cell types express TSPO meningiomas. Immunohistochemistry 38 WHO grade 1–3 meningiomas was subjected segmentation deep learning classification expression either Iba1-positive tumor-associated...