A5000241903- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Climate Change and Health Impacts
- Viral Infections and Immunology Research
- Musculoskeletal synovial abnormalities and treatments
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Spondyloarthritis Studies and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Global Health and Surgery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Orthopedic Infections and Treatments
- Lymphadenopathy Diagnosis and Analysis
- Sarcoidosis and Beryllium Toxicity Research
- Orthopaedic implants and arthroplasty
- Biosimilars and Bioanalytical Methods
- Systemic Sclerosis and Related Diseases
- Healthcare cost, quality, practices
- Herpesvirus Infections and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Diakonhjemmet Hospital
2015-2024
Institute for Rheumatic Diseases (Japan)
2023
University of Oslo
2018-2021
American College of Rheumatology
2018
Oslo University Hospital
2018
Leiden University Medical Center
2018
To determine whether a treatment strategy based on structured ultrasound assessment would lead to improved outcomes in rheumatoid arthritis, compared with conventional strategy. Multicentre, open label, two arm, parallel group, randomised controlled trial. Ten rheumatology departments and one specialist centre Norway, from September 2010 2015. 238 patients were recruited between April 2013, of which 230 (141 (61%) female) received the allocated intervention analysed for primary outcome. The...
Including carbon footprint as an end point in randomized, controlled trials could help clinicians, regulators, and policymakers understand the environmental effects of medical interventions.
To compare the presentation of seropositive and seronegative early rheumatoid arthritis (RA) in disease-modifying antirheumatic drug (DMARD)-naïve patients classified according to 2010 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria.All had symptom duration from first swollen joint <2 years were DMARD naïve with an indication for treatment. Patients stratified as (positive factor (RF)+ and/or anticitrullinated peptide antibody (ACPA)+) or (RF- ACPA-),...
Objectives Recent studies suggest that implementation of the 2010 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis (RA) leads to higher inflammatory activity in seronegative compared with seropositive patients at time diagnosis. Our aim was compare disease course and classified according criteria. Methods DMARD-naïve RA fulfilling were included treat-to-target ARCTIC trial followed 24 months. We stratified as...
Abstract The association between pulmonary sequelae and markers of disease severity, as well pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. COPD assessment test (CAT-score), spirometry, diffusion capacity the lungs (DL CO ), chest-CT performed at 23 Norwegian hospitals included NOR-SOLIDARITY trial, an open-labelled, randomised clinical investigating efficacy remdesivir hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10....
Objectives To investigate if inflammation detected by MRI or ultrasound at rheumatoid arthritis (RA) onset is predictive of erosive progression poor response to methotrexate monotherapy, and subclinical in remission future treatment escalation progression. Methods In a 2-year study, 218 patients with disease-modifying antirheumatic drug-naïve early RA were treated tight-control treat-to-target strategy corresponding current recommendations. performed regular intervals. Baseline imaging-based...
Objectives Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity fatigue patients with early RA during the initial 24 months modern treat-to-target therapy predictors after follow-up. Methods Data were obtained from treat-to-target, tight control Aiming for Remission Rheumatoid Arthritis: Randomised Trial Examining Benefit Ultrasound Clinical Tight Control Regime (ARCTIC) trial. was measured visual...
Intraarticular glucocorticoid injections are common in rheumatoid arthritis (RA) treatment. This study was undertaken to investigate whether ultrasound combination with clinical examination is better than alone at identifying joints that will benefit from intraarticular injections, and compare the efficacy of ultrasound-guided versus palpation-guided procedures.In treat-to-target Aiming for Remission Rheumatoid Arthritis: a Randomised Trial Examining Benefit Ultrasonography Clinical Tight...
Objectives To explore the performance of EULAR-initiated patient-reported Rheumatoid Arthritis Impact Disease (RAID) questionnaire in relation to flares disease activity, including comparison with other activity outcomes. Methods Patients rheumatoid arthritis sustained remission were randomised continued stable treatment or tapering ARCTIC REWIND project. In patients within 12 months, we compared RAID (total score and components) at flare visit prior following flare, using Wilcoxon...
To investigate whether an ultrasound-guided treat-to-target strategy for early RA would lead to reduced MRI inflammation or less structural damage progression compared with a conventional strategy.A total of 230 DMARD-naïve patients were randomized ultrasound tight control targeting DAS <1.6, no swollen joints and power Doppler signal in any joint <1.6 joints. Patients both arms treated according the same DMARD escalation strategy. dominant hand was performed at six time points over 2 years...
<h3>Background</h3> Application of ultrasound (US) in the management patients with rheumatoid arthritis (RA) is rapidly growing. <h3>Objectives</h3> The randomized controlled ARCTIC trial (ClinicalTrials.gov NCT01205854) examined if use a treatment strategy based on structured US assessment<sup>1</sup> would lead to improved outcomes RA, compared conventional clinical and laboratory assessments alone. <h3>Methods</h3> Newly diagnosed DMARD naïve RA were 1:1 A) an tight control (UTC)...
Objectives To explore the agreement between patient-reported flare status and clinically significant in patients with rheumatoid arthritis (RA) sustained remission. Method Patients RA remission for ≥12 months on stable treatment were included ARCTIC REWIND tapering trials pooled 12-month data used current analyses. Patient-reported was assessed according to Outcome Measures Rheumatology questionnaire; ‘Are you having a of your at this time?’ (yes/no). A defined as combination Disease...
<h3>Background</h3> The RAID score is a relatively new patient-derived composite assessing seven important domains of the impact rheumatoid arthritis (RA). It unknown how correlates with various disease measures among patients early RA. <h3>Objectives</h3> To examine associations between and other patient reported outcome (PROMs) clinical, laboratory ultrasonographic in an inception cohort DMARD naïve <h3>Methods</h3> Patients from 11 centers who fulfilled 2010 ACR/EULAR classification...
<h3>Background</h3> Ultrasonography (US) is increasingly an important tool in diagnosis and management of rheumatoid arthritis (RA). However, the knowledge regarding to what extent US adds information clinical examination at individual joint level limited. <h3>Objectives</h3> To assess concordance between detecting pathology a cohort early RA patients. <h3>Methods</h3> 228 patients with who fulfilled 2010 ACR/EULAR classification criteria were recruited 11 rheumatology centers 2013. Patients...
<h3>Background</h3> The development of the 2010 classification criteria for rheumatoid arthritis (RA) has led to a redefinition patient population, including seropositive vs. seronegative patients. Studies have yielded conflicting results on whether and RA are different disease entities. <h3>Objectives</h3> Our aim was compare characteristics DMARD-naïve early patients classified according ACR/EULAR criteria. <h3>Methods</h3> who fulfilled were recruited at 11 rheumatology centers between...
<h3>Background</h3> Ultrasound is increasingly applied in the management of rheumatoid arthritis (RA). It important to detect synovitis early prevent future joint damage and disability. not known whether subclinical ultrasound inflammation a precedes clinical swelling. <h3>Objectives</h3> We aimed investigate power Doppler (PD) activity associated with subsequent swelling RA patients. <h3>Methods</h3> In treat-to-target ARCTIC trial, DMARD naïve patients were randomised follow-up or without...