A5101760015- Cancer Genomics and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Cardiac Arrest and Resuscitation
- Gene expression and cancer classification
- Reproductive System and Pregnancy
- Leptospirosis research and findings
- Gynecological conditions and treatments
- Medical Imaging and Pathology Studies
- Genomics and Rare Diseases
- Colorectal Cancer Treatments and Studies
- Cardiovascular Health and Disease Prevention
- Sulfur-Based Synthesis Techniques
- Coronary Artery Anomalies
- Inorganic Chemistry and Materials
- Congenital Diaphragmatic Hernia Studies
- Synthesis of β-Lactam Compounds
- Infectious Encephalopathies and Encephalitis
- Blood Pressure and Hypertension Studies
- Protein Tyrosine Phosphatases
- Genetic Associations and Epidemiology
- Autopsy Techniques and Outcomes
Shanxi Medical University
2025
Sun Yat-sen University
2017-2023
Southern University of Science and Technology
2023
Hainan General Hospital
2021
Inner Mongolia Medical University
2018-2020
Shenzhen Children's Hospital
2020
Burning Rock Biotech (China)
2019
Hospital for Sick Children
2019
Inner Mongolia University
2018
Hebei Normal University
2017
The enantioconvergent C(sp3)-N cross-coupling of racemic alkyl halides with (hetero)aromatic amines represents an ideal means to afford enantioenriched N-alkyl yet has remained unexplored due the catalyst poisoning specifically for strong-coordinating heteroaromatic amines. Here, we demonstrate a copper-catalyzed radical activated under ambient conditions. key success is judicious selection appropriate multidentate anionic ligands through readily fine-tuning both electronic and steric...
Abstract Genomic identification of driver mutations and genes in cancer cells are critical for precision medicine. Due to difficulty modelling distribution background mutation counts, existing statistical methods often underpowered discriminate cancer-driver from passenger genes. Here we propose a novel approach, weighted iterative zero-truncated negative-binomial regression (WITER, http://grass.cgs.hku.hk/limx/witer or KGGSeq,http://grass.cgs.hku.hk/limx/kggseq/), detect showing an excess...
Hearing loss significantly affects children's lives; however, the health-related quality of life (QoL) children with this disability is not well measured. We sought to develop a reliable and valid measure QoL in hearing loss. constructed conceptual framework assess based on Pediatric Quality Life Inventory™ Version 4.0 child scale World Health Organization Brief general version. The item pool was generated through two rounds Delphi method subsequent group discussions. Subsequently, both...
Abstract The ground-state magnetic ordering of uranium mononitride (UN) remains a contentious topic due to the unexpected lack crystallographic distortion in traditionally accepted 1 k antiferromagnetic (AFM) state. This discrepancy casts doubt on validity UN. Here, we investigate crystal structure, high-pressure phase transitions, dynamical, and mechanical properties 3 AFM UN within density functional theory (DFT). Our results reveal that undistorted state Fm3m DFT+ U +SOC scheme is more...
To investigate the correlation between high-risk human papillomavirus (HR HPV)-negative cervical lesions and microenvironment in Inner Mongolia, China, to find pathogenic factors of HR HPV-negative lesions. 74 cases healthy women 80 patients with (28 LSIL, 49 HSIL 3 CSCC) were selected as study group; 26 HPV-positive 352 (108 214 30 control group. Questionnaires collected from group specimens collected. Gram staining, hematoxylin eosin staining microscopy, substrate colorimetry method used...
Abstract The purpose of this study was to assess the association blood pressure (BP) measurements with risk cardiovascular disease (CVD) and examine whether central systolic BP (CSBP) predicts CVD better than brachial (SBP pulse [PP]). Based on a cross‐sectional conducted in 2009‐2010 follow‐up 2016‐2017 among 35‐ 64‐year‐old subjects China, we evaluated performance non‐invasively predicted CSBP over first events. Each measurement, individually jointly another entered into multivariate Cox...
The incidence of Kawasaki disease (KD) is increasing. Indeed, KD has become the most common cause acquired heart in children. Previous studies have well summarized acute phase left ventricular (LV) systolic dysfunction using speckle tracking echocardiography (STE); however, changes LV function after long-term follow-up remain unclear.One hundred children with a history KD, but without coronary artery aneurysms, were enrolled. These divided into two subgroups based on presence or absence...
Haemaphysalis longicornis is a blood-sucking ectoparasite that can cause diseases by transmitting some pathogens to humans and animals. Paramyosin (Pmy) an immunomodulatory protein, which plays important role in immune reactions against parasites. In this study, we evaluated the protection elicited recombinant plasmids encoding H. Pmy rabbits. Rabbits vaccinated with pcDNA3.1(+)-Pmy developed high level of IgG compared control group, suggesting humoral response was induced vaccination. On...
A copper-catalyzed enantioconvergent radical C(sp
Studies regarding sport-related sudden cardiac death (SCD) mainly focus on competitive athletes; similar data are rare in the general population, especially China. We conducted a retrospective study (from September 1998 to August 2013) investigate aetiological distribution and epidemiological features of SCD Southern Selections cases based details, two subgroups were established: one was group, other disease-free accident victims group which matched with gender, age year death. Among 3770...
Abstract Differences among SNP panels for individual identification in SNP-selecting and populations led to few common SNPs, compromising their universal applicability. To screen all we performed a genome-wide mining multiple based on HapMap 1000Genomes databases. SNPs with high minor allele frequencies (MAF) 37 were selected. With MAF from ≥0.35 ≥0.43, the number of selected decreased 2769 0. A total 117 ≥0.39 have no linkage disequilibrium each other every population. For 116 cumulative...
Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. STK11 has been identified as causative gene for this disease. Herein we report Chinese Han kindred with PJS. Onset the PJS signs in three of patients was rarely early at birth. We novel heterozygous mutation (c.440_441delGT, p.Arg147Leufs*15) STK11, causing short frameshift followed deletion 63% amino acids STK protein. This co-segregated phenotype,...
To investigate correlation between abnormal replicative senescence of endometrial gland epithelial cells (EGECs) in shedding and non-shedding endometria endometriosis cyst during menstruation. Musashi-1 expression, β-catenin EGECs ultrastructure endometrium when menstruation were observed through real-time PCR transmission electron microscopy technologies. (1) exhibited a high expression experimental group, showing positive each other; significantly higher than that control group. However;...
Background: This study sought to assess the correlation between level of physical activity (PA) and quality on life 1 year after stroke.Methods: The subjects for this comprised 122 patients who had their first stroke were admitted our hospital from June 2019 December 2020. self-rating Stroke Impact Scale (SIS) was used evaluate impact cognition. SIS uses a total 59 items across 8 different dimensions (i.e., strength, memory, emotion, communication, activities daily living, ability, hand...
Abstract Background Hypertrophic cardiomyopathy (HCM) is predominantly caused by mutations in sarcomeric genes. However, a subset of cases attributed to genetic disorders unrelated genes, such as Noonan syndrome (NS) and other RASopathies. In this study, we present family with history sudden cardiac death (SCD) focus on two adults syndromic left ventricular hypertrophy (LVH). Methods Clinical evaluations, including echocardiography, were conducted assess manifestations. Whole‐exome...
Abstract Genomic identification of driver mutations and genes in cancer cells are critical for precision medicine. Due to difficulty modeling distribution background mutations, existing statistical methods often underpowered discriminate from passenger genes. Here we propose a novel approach, weighted iterative zero-truncated negative-binomial regression (WITER), detect cancer-driver showing an excess somatic mutations. By solving the problem inaccurately this approach works even small or...
Abstract Thousands of DNA sequences in global populations are not present the human reference genome, named nonreference sequence (NRS). Long-read sequencing (LRS) technologies enable better discovery NRS with large length, particularly repetitive regions. Here, we de novo assembled 539 genomes five genetically divergent sequenced by LRS technology and identified 5.1 million NRSs. These NRSs were merged into 45,284 nonredundant NRSs, which 66.2% novel. 78.5% repeat sequences, such as VNTR...
Primary systemic carnitine deficiency (CDSP) is a rare disease that can lead to sudden cardiac death (SCD). Meanwhile, manifestations had been widely reported in CDSP cases. Researches on phenotype and mechanism are needed imperatively evaluate the influence of cardiovascular system. We induce an intraperitonealinjected mouse model transgenic created by CRISPR/Cas-mediated genome engineering observe ECG echocardiography parameters explore pathophysiological features deficiency. In female...