A5042521708- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Insect and Pesticide Research
- Healthcare and Venom Research
- Advancements in Transdermal Drug Delivery
- Insect Utilization and Effects
- Insect and Arachnid Ecology and Behavior
- Medical and Biological Ozone Research
- Sperm and Testicular Function
- Pomegranate: compositions and health benefits
- Effects of Radiation Exposure
- Immunotherapy and Immune Responses
- Agricultural and Food Sciences
- Plant and animal studies
- Cytomegalovirus and herpesvirus research
- Nail Diseases and Treatments
- Diabetes and associated disorders
- Dermatologic Treatments and Research
- Plant Toxicity and Pharmacological Properties
- T-cell and Retrovirus Studies
- IL-33, ST2, and ILC Pathways
- Therapeutic Uses of Natural Elements
- Nigella sativa pharmacological applications
- Urban Development and Societal Issues
- Pesticide Exposure and Toxicity
Universidade Estadual Paulista (Unesp)
2011-2023
Universidade de São Paulo
2020
Albany Medical Center Hospital
2012
King's College London
2011
Propolis is one of the most fascinating honey bee (Apis mellifera L.) products. It a plant derived product that bees produce from resins they collect different organs and with which mix beeswax. building material protective agent in hive. also plays an important role social immunity, widely used by humans as ingredient nutraceuticals, over-the-counter preparations cosmetics. Its chemical composition varies geographic location, climatic zone local flora. The understanding diversity propolis...
Propolis is a beehive product and its immunomodulatory action has been documented; however, little known concerning mechanisms of on human cells. influence the initial events immune response was assessed, evaluating cell markers, cytokine production fungicidal activity monocytes.Toll-like receptor (TLR)-2, TLR-4, leukocyte antigen-DR cluster differentiation (CD)80 expression by monocytes assessed using FACSCalibur flow cytometer, (tumour necrosis factor (TNF)-α interleukin (IL)-10)...
In traditional medicine, plants have formed the basis of sophisticated systems that been in existence for thousands years and still provide mankind with new remedies. Cymbopogon martinii, known as palmarosa, has used aromatherapy a skin tonic due to its antimicrobial properties. It also Ayurvedic medicine problems relieve nerve pain. The immunomodulatory action C. martinii essential oil (EO) geraniol was evaluated regarding production pro- anti-inflammatory cytokines (tumour necrosis factor...
Propolis is a beehive product used in traditional medicine due to its biological properties. It shows complex chemical composition including phenolics, such as cinnamic acid (Ci). The mechanisms of action propolis have been the subject research recently; however, involvement Ci on activity was not investigated immune cells. effects were evaluated human monocytes, assessing expression Toll-like receptors (TLRs), HLA-DR, and CD80. Cytokine production (TNF- α IL-10) fungicidal monocytes well....
Propolis is a bee product with several biological properties. This study aimed at investigating propolis-containing mouthwash, its organoleptic properties, microbial contamination and antibacterial action in vitro. mouthwash was assessed vivo to control dental plaque humans. The presence of microorganisms analyzed the minimum inhibitory concentration against Streptococcus mutans determined. A comparative done using propolis, chlorhexidine, propolis plus chlorhexidine lower concentrations for...
Abstract Objectives Dendritic cells (DCs) are antigen-presenting cells, essential for recognition and presentation of pathogens to T cells. Propolis, a resinous material produced by bees from various plants, exhibits numerous biological properties, highlighting its immunomodulatory action. Here, we assayed the effects propolis on maturation function human DCs. Methods DCs were generated monocytes incubated with LPS. NF-κB cytokines production determined ELISA. microRNA's expression was...
Propolis is a natural product with complex chemical composition. Its isolated compounds exert biological activities; however, its synergistic effects are unknown. The involvement of phenolic acids (caffeic - Caf, dihydrocinnamic Cin and p-coumaric Cou) alone or in combination was investigated the action propolis human monocytes.Cell viability analysed by MTT assay; TNF-α, IL-6 IL-10 production enzyme-linked immunosorbent assay (ELISA); cell markers expression flow cytometry; colony-forming...
Propolis is a bee product used in folk medicine to improve health and prevent inflammatory diseases. It has attracted the attention of researchers from odontological field lately, reducing inflammation resulting surgical procedures as an antimicrobial agent control bacterial plaque. Thus far, no side-effects that might compromise oral have been observed. Chlorhexidine widely antiseptic, but restrict its use. This work investigated effects containing propolis combination with chlorhexidine...
Abstract Objectives Propolis is a bee-made product used for centuries due to its diverse biological properties, including immunomodulatory action. This work aimed at investigating whether propolis may affect monocyte functions challenged with retinoic acid (RA), B subunit of Escherichia coli heat-labile enterotoxin (EtxB), human melanoma-associated antigen-1 (MAGE-1) and lipopolysaccharide (LPS). Methods Monocytes from healthy donors were treated the stimuli separately or in presence...
Osteosarcoma (OSA) is a type of bone cancer showing an aggressive biological behavior with metastatic progression. Because propolis potential for the development new antitumoral drugs has been indicated, we evaluated chemical composition Colombian samples and mechanisms involved in their cytotoxic effects on OSA cells. The was analyzed by GC–MS DPPH free radical scavenging activity measured. Cluster principal components analysis were used to establish association inhibitory concentration 50%...
The same propolis sample that was analyzed by GC-MS in 1997 and 2012 examined again after being frozen for 15 years. No qualitative changes were seen its composition; artepilin C, prenyl-p-coumaric acid, dihydrocinnamic caffeic acid the major compounds.
Docetaxel (DTX) is used against breast cancer despite its side effects such as toxicity and immunosuppression. Here we investigated the cytotoxic immunomodulatory of ethanol solution extract propolis (EEP) in combination with DTX on MCF-7 cells women's monocyte. The potential EEP + was assessed by MTT assay type tumor cell death evaluated flow cytometry. migration invasion were analyzed. Cytokine production monocytes ELISA expression surface markers We also fungicidal activity Candida...
Background: Propolis exhibits huge potential in the pharmaceutical industry. In present study, its effects were investigated on dendritic cells (DCs) stimulated with a tumor antigen (MAGE-1) and retinoic acid (RA) T lymphocytes to observe possible differential activation of lymphocytes, driving preferentially Th1 or Treg cells. Methods: Cell viability, lymphocyte proliferation, gene expression (T-bet FoxP3), cytokine production by DCs (TNF-α, IL-10, IL-6 IL-1β) (IFN-γ TGF-β) analyzed....
Abstract Objectives Geopropolis (GEO) in combination with doxorubicin (DOX) reduced HEp-2 cells viability compared to GEO and DOX alone. A possible effect of this on the innate immunity could take place, its effects were analysed THP-1 cell – a human leukaemia monocytic line used as model study monocyte activity macrophage activity, assessing viability, expression markers cytokine production. Methods incubated GEO, their combination. Cell was assessed by MTT assay, flow cytometry production...
Dendritic cells (DCs) are antigen-presenting that drive the differentiation of T CD4+ into different profiles according to nature antigen or immunomodulator. Propolis is a resinous product made by bees has numerous pharmacological properties, including an immunomodulatory action. To assess whether propolis can modulate activation stimulating DCs with heat-labile enterotoxin B subunit (EtxB) lipopolysaccharide (LPS), we aimed elucidate mechanisms affected in differential lymphocytes. Cell...
Bloodstream infections caused by Candida species are responsible for high morbidity and mortality, diabetes mellitus (DM) is an important underlying disease in candidemia episodes. Although DM patients show enhanced proinflammatory profile, they highly susceptible to mycobacterial mycotic infections. Attempting understand this paradox, we investigated if imbalanced macrophage dendritic cell (DC) activations could be associated incidence and/or severity of albicans infection the...