A5063928335- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- COVID-19 epidemiological studies
- Trypanosoma species research and implications
- SARS-CoV-2 and COVID-19 Research
- Parasitic Diseases Research and Treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Parasite Biology and Host Interactions
- HIV/AIDS Impact and Responses
- COVID-19 Pandemic Impacts
- Vaccine Coverage and Hesitancy
- COVID-19 diagnosis using AI
- Insect Pest Control Strategies
- Leptospirosis research and findings
- Insect and Pesticide Research
- Mosquito-borne diseases and control
- Economic Analysis and Policy
- Entrepreneurship Studies and Influences
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Global Maternal and Child Health
- Vibrio bacteria research studies
- Data-Driven Disease Surveillance
- COVID-19 and Mental Health
Swiss Tropical and Public Health Institute
2019-2024
University of Basel
2019-2024
The University of Western Australia
2024
Erasmus University Rotterdam
2020-2023
Erasmus MC
2015-2022
Imperial College London
2022
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
University of Warwick
2022
University of Oxford
2022
Abstract Due to the COVID-19 pandemic, many key neglected tropical disease (NTD) activities have been postponed. This hindrance comes at a time when NTDs are progressing towards their ambitious goals for 2030. Mathematical modelling on several NTDs, namely gambiense sleeping sickness, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases (STH), trachoma, and visceral leishmaniasis, shows that impact of this disruption will vary across diseases. Programs face...
Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need develop these inform policy achieve the 2020 goals for neglected tropical diseases (NTDs). In this paper we give overview of a collection novel model-based analyses which aim address key questions on dynamics transmission nine NTDs: Chagas disease, visceral leishmaniasis, human African trypanosomiasis, leprosy, soil-transmitted helminths,...
Background The World Health Organization (WHO) has set ambitious time-bound targets for the control and elimination of neglected tropical diseases (NTDs). Investing in NTDs is not only seen as good value money, but also advocated a pro-poor policy since it would improve population health poorest populations. We studied extent to which disease burden from nine (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, trachoma, Chagas disease, human African...
As vaccination coverage against SARS-CoV-2 increases amidst the emergence and spread of more infectious potentially deadly viral variants, decisions on timing extent relaxing effective, but unsustainable, non-pharmaceutical interventions (NPIs) need to be made.An individual-based transmission model dynamics, OpenCOVID, was developed compare impact various NPI strategies COVID-19 epidemic in Switzerland. OpenCOVID uses Oxford Containment Health Index (OCHI) quantify stringency NPIs.Even if...
Leishmania infections are global, occurring in 98 countries and all World Health Organization (WHO) regions with 600 million to 1 billion people at risk of infection. Visceral leishmaniasis is associated almost 20,000 reported deaths annually, children under 5 years age being the greatest mortality. Amongst WHO-recognised Neglected Tropical Diseases (NTDs), one most important terms mortality morbidity. With an increasing global burden disease a growing threat from climate change,...
Background The London Declaration (2012) was formulated to support and focus the control elimination of ten neglected tropical diseases (NTDs), with targets for 2020 as by WHO Roadmap. Five NTDs (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths trachoma) are be controlled preventive chemotherapy (PCT), four (Chagas' disease, human African trypanosomiasis, leprosy visceral leishmaniasis) innovative intensified disease management (IDM). Guinea worm, virtually...
We present three transmission models of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) with structural differences regarding disease stage that provides main contribution to transmission, including a prominent role asymptomatic infection, and fit them recent case data from 8 endemic districts Bihar, India. Following geographical cross-validation models, we compare their predictions for achieving WHO VL elimination targets ongoing treatment vector control strategies. All suggest...
Visceral leishmaniasis (VL) is a neglected tropical disease transmitted by sandflies. On the Indian subcontinent (ISC), VL targeted for elimination as public health problem 2017. In context of VL, target defined an annual incidence <1 per 10,000 capita at (sub-)district level. Interventions focus on vector control, surveillance and diagnosing treating cases. Many endemic areas have not yet achieved optimal control due to logistical, biological well technical challenges. We used mathematical...
SARS-CoV-2 variants of concern, such as Omicron (B.1.1.529), continue to emerge. Assessing the impact their potential viral properties on probability future transmission dominance and public health burden is fundamental in guiding ongoing COVID-19 control strategies.
Visceral leishmaniasis (VL) has been targeted by the WHO for elimination as a public health problem (< 1 case/10,000 people/year) in Indian sub-continent (ISC) 2020. Bihar State India, which accounts majority of cases ISC, remains major target this effort. However, there is considerable spatial, temporal and sub-population variation occurrence disease pathway to care, largely unexplored threat achieving target. Data from 6081 suspected VL patients who reported being clinically diagnosed...
Visceral leishmaniasis (VL) has been targeted by the World Health Organization (WHO) and 5 countries in Indian subcontinent for elimination as a public health problem. To achieve this target, WHO developed guidelines consisting of 4 phases different levels interventions, based on vector control through indoor residual spraying insecticide (IRS) active case detection (ACD). Mathematical transmission models VL are increasingly used planning assessing efficacy interventions evaluating intensity...
BackgroundNepal launched a visceral leishmaniasis (also known as kala-azar) elimination initiative in 2005. We primarily aimed to assess whether transmission of Leishmania donovani had decreased since the launch initiative. also assessed validity direct agglutination test (DAT) marker infection, view future surveillance systems.MethodsWe did repeat survey population aged 2 years and older for whom baseline serological data were available from 2006. Data three districts eastern region Nepal....
The development of vaccines against one or all forms human leishmaniasis remains hampered by a paucity investment, at least in part resulting from the lack well-evidenced and agreed estimates vaccine demand. Starting definition 4 main use cases (prevention visceral leishmaniasis, prevention cutaneous post-kala-azar dermal treatment leishmaniasis), we have estimated size each target population, focusing on those endemic countries where incidence levels are sufficiently high to justify...
Vaccinations have reduced severe burden of COVID-19 and allowed for lifting non-pharmaceutical interventions. However, with immunity waning alongside emergence more transmissible variants concern, vaccination strategies must be examined.Here we apply a SARS-CoV-2 transmission model to identify preferred frequency, timing, target groups vaccine boosters reduce public health systems risk. We estimated new infections hospital admissions averted over 2 years through annual or biannual boosting...
Background The control or elimination of neglected tropical diseases (NTDs) has targets defined by the WHO for 2020, reinforced 2012 London Declaration. We estimated economic impact to individuals meeting these human African trypanosomiasis, leprosy, visceral leishmaniasis and Chagas disease, NTDs controlled eliminated innovative intensified disease management (IDM). Methods A systematic literature review identified information on productivity loss out-of-pocket payments (OPPs) related NTDs,...
Background Despite the overall decrease in visceral leishmaniasis (VL) incidence on Indian subcontinent, there remain spatiotemporal clusters or 'hotspots' of new cases. The characteristics these hotspots, underlying transmission dynamics, and their importance for shaping control strategies are not yet fully understood investigated this study a VL endemic area ~100,000 inhabitants Bihar, India between 2007–2015. Methodology/Principal findings (cases/10,000/year) dropped from 12.3 2007 to 0.9...
In 2023 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared endemic, yet hospital admissions have persisted and risen within populations at high moderate risk of developing disease, which include those older age, with co-morbidities. Antiviral treatments, currently only available for high-risk individuals, play an important role in preventing disease hospitalisation this subpopulation. Here, we further explore the public health economic benefits extending target...
Zoonotic visceral leishmaniasis (ZVL) is a parasitic disease affecting dogs and humans, which transmitted by female sandflies. Over the last decade, prevalence has increased fivefold in parts of southern Europe, where an estimated 2.5 million are infected. This increase mainly due to expansion sandfly distribution climate change greater numbers travelling among European countries. To combat spread ZVL international guidelines have been drawn up that describe strategies prevent, control...
Human visceral leishmaniasis (VL) vaccines are currently under development and there is a need to understand their potential impact on population wide VL incidence. We implement four characteristics from different human vaccine candidates into two published transmission model variants estimate the of these population-wide anthroponotic incidence Indian subcontinent (ISC). The that simulated in this study 1) reduce infectiousness infected individuals towards sand flies, 2) risk developing...
Abstract Background In March 2020, India declared a nationwide lockdown to control the spread of coronavirus disease 2019. As result, efforts against visceral leishmaniasis (VL) were interrupted. Methods Using an established age-structured deterministic VL transmission model, we predicted impact 6- 24-month programme interruption on timeline towards achieving elimination target as well increase cases. We also explored potential mitigation strategy after interruption. Results Delays are...
Control of visceral leishmaniasis (VL) on the Indian subcontinent relies prompt detection and treatment symptomatic cases. Detection efforts influence observed VL incidence how well it reflects underlying true incidence. As control targets are defined in terms cases, there is an urgent need to understand changes delay population coverage improved affect control.Using a mathematical model for transmission VL, we predict impact reduced delays and/or increased programs mortality.Improved case...