A5015494947- RNA Interference and Gene Delivery
- Angiogenesis and VEGF in Cancer
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Dental Implant Techniques and Outcomes
- Advanced biosensing and bioanalysis techniques
- Orthopaedic implants and arthroplasty
- Virus-based gene therapy research
- Plant-Microbe Interactions and Immunity
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Mycotoxins in Agriculture and Food
- Environmental DNA in Biodiversity Studies
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- Bone and Joint Diseases
- Cancer Cells and Metastasis
- Advanced Biosensing Techniques and Applications
- Escherichia coli research studies
- Graphene and Nanomaterials Applications
- Cancer-related gene regulation
- Heat shock proteins research
Southwest Medical University
2021-2025
Anyang Academy of Agricultural Sciences
2022-2025
Academy of Military Medical Sciences
2013-2024
Hebei University
2024
Shenzhen University
2023
Shenzhen University Health Science Center
2021-2022
Nankai University
2022
Ministry of Education
2022
State Key Laboratory of Medicinal Chemical Biology
2022
Stomatology Hospital
2022
Background To date, breast cancer remains the primary cause of tumor-related death among women, even though some leap-type developments oncology have been done to slash mortality. Considering tumor heterogeneity and individual variation, more reliable biomarkers are required be identified for supporting development precision medicine in cancer. Methods Based on TCGA-BRCA METABRIC databases, differently expressed RNA binding proteins (RBPs) between normal tissues were investigated. In this...
Pancreatic cancer is an aggressive malignancy associated with poor prognosis and a high tendency in developing infiltration metastasis. K-ras mutation major genetic disorder pancreatic patient. RNAi-based therapies can be employed for combating by silencing gene expression. However, the clinical application of RNAi technology appreciably limited lack proper siRNA delivery system. To tackle this hurdle, cationic poly (cyclohexene carbonate) s (CPCHCs) using widely sourced CO2 as monomer are...
Rapid detection of crop grain components is crucial for effective production and energy conversion. We used the sample set division method to divide multiple sets optimize NIRS models rapid prediction protein fat content. 1243 415 samples were screened divided into 5 4 sets, respectively. The aim was establish content prediction. best modeling methods N (Norris Derivative)+D (detrending)-C (CARS)-P (PLS) N+M (MC-UVE)-C-P, while those N+M-C-P N+S (Savitzky-Golay)-C-P. SS (Soybean Set), KS...
Abstract Background: Both B7H3 and PD-(L)1 are highly expressed in various solid tumors, including lung cancer, hepatocellular breast melanoma, many others. Dual blockade of improved antitumor activity compared to either agent alone. However, no bispecific antibodies targeting both clinical development. DB-1419 is a antibody-drug conjugate (ADC) comprised humanized anti-B7H3/PD-L1 IgG1 antibody covalently linked proprietary DNA topoisomerase I inhibitor (P1003) via cleavable linker...
In this study, we examined the effect of GP130-targeting molecule, LMT-28, on lipopolysaccharide- (LPS-) induced bone resorption around implants in diabetic models using vitro and rat animal experiments. First, LMT-28 was added to osteoblasts stimulated by LPS advanced glycation end products (AGEs), nuclear factor-κB receptor-activating factor ligand (RANKL) associated pathways were evaluated. Then, administered gavage at 0.23 mg/kg once every 5 days for 2 weeks type rats with...
Osteosarcoma often occurs in children and adolescents with high invasiveness mortality. Polo-like kinase 1 (PLK1) overexpressed most tumors promotes cancer cell proliferation transformation. PLK1 is considered as a therapeutic target for osteosarcoma. RNA interference-based therapies are employed to combat osteosarcoma through silencing gene expression. However, the treatment results remain unsatisfactory due lack of safe efficient nonviral vector. To tackle this hurdle, biodegradable CO2...
Abstract The use of next generation sequencing is increasing in the field forensic genomics. This study assesses performance Illumina's MiSeq FGx System recovery genomic information from degraded and low‐template DNA. analysis involved a sensitivity where range 1 ng to 5 pg 2800M DNA was utilized. artificially systematically by incubating 2800 M at 98°C for 10, 20, 30, 40, 50, 60, 70, 120 180 min (resulting degradation index values ranging 0.837 232.247). results revealed detected allele...
Purpose: Vasculogenic mimicry (VM) is known to be a mechanism nourish the tumor, but little about its prognostic significance in esophageal squamous cell carcinoma (ESCC). We characterized predictive relevance of VM expression and tumor-infiltrating neutrophil (TIN) density patients with resectable ESCC. Methods: retrospectively collected clinicopathologic characteristics 117 cancer (EC) undergoing complete resection without preoperative therapy. Immunohistochemistry was used detect...
It is currently unclear if a low insertion torque (IT) should prompt clinician to submerge the dental implant at time of placement.This study aimed analyze failure rates and marginal bone loss (MBL) as function IT surgical approach.A total 197 patients who had received 295 Mozo Grau (MG) implants were included in this study. The healing submerged or nonsubmerged was evaluated regular (≥20-25 Ncm) (<20-25 cases. Implant MBL before prosthesis placement 6 12 months after functional loading with...
Calcium (Ca 2+ ) is the most abundant divalent cation in plants, and cellular levels of Ca , which functions as a nutrient secondary messenger, play critical role plant immunity. In present study, we found that FERONIA-like receptor 1 (FLR1) positively regulates Magnaporthe oryzae resistance expression FLR1 strongly induced response to deficiency. addition, content shoots flr1 was lower than wild-type, M. -sensitive phenotype mutant not rescued by exogenous application . Moreover, RNA...
Purpose: Recent studies demonstrate the possible antitumor effects of granulocyte-macrophage colony-stimulating factor (GM-CSF); however, exact mechanism is still unclear. The aim our study was to analyze GM-CSF on multiple biological functions human esophageal cancer (EC) cell lines and explore potential its effects. Materials methods: Eca109/9706 EC cells were examined. Cell proliferation, apoptosis, migration analyzed using proliferation assay, flow cytometry, transwell respectively....
This study aims to compare the accuracy of self-developed universal implant guide (SDG), 3D printed digital (DG), and free hand (FH) simulated implantation in posterior tooth area dental models.
Retinoic acid signaling pathway plays a role in regulating vertebrate development, cell differentiation, and homeostasis. As key enzyme that catalyzes the oxidation of retinal to retinoic acid, aldehyde dehydrogenase 1 family member A2 (Aldh1a2) is involved cardiac while whether it functions heart diseases remains be studied. In this study, we infected primary cardiomyocytes with adenovirus overexpressing