A5026660196- TGF-β signaling in diseases
- Pluripotent Stem Cells Research
- Reproductive Physiology in Livestock
- Carcinogens and Genotoxicity Assessment
- Ubiquitin and proteasome pathways
- Developmental Biology and Gene Regulation
- Sperm and Testicular Function
- Planarian Biology and Electrostimulation
- Reproductive System and Pregnancy
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Peroxisome Proliferator-Activated Receptors
- Anatomy and Medical Technology
- Reproductive Biology and Fertility
- Lipid metabolism and disorders
- Radiation Dose and Imaging
- Hippo pathway signaling and YAP/TAZ
- Neonatal Respiratory Health Research
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
- Effects of Radiation Exposure
- Veterinary Equine Medical Research
- Congenital heart defects research
- Barrier Structure and Function Studies
Inserm
2019-2024
Université de Bordeaux
2024
Bordeaux Population Health
2024
CEA Paris-Saclay
2020-2023
Université Paris Cité
2020-2023
Université Paris-Saclay
2020-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2020-2023
Sorbonne Paris Cité
2020-2021
Délégation Paris 7
2020-2021
Université Paris-Sud
2020-2021
Rostro-caudal patterning of vertebrates depends on the temporally progressive activation HOX genes within axial stem cells that fuel embryo elongation. Whether pace sequential genes, 'HOX clock', is controlled by intrinsic chromatin-based timing mechanisms or temporal changes in extrinsic cues remains unclear. Here, we studied clock pacing human pluripotent cell-derived progenitors differentiating into diverse spinal cord motor neuron subtypes. We show caudal a dynamic increase FGF...
Experimental autoimmune epididymo-orchitis (EAEO) is a model of chronic inflammation, induced by immunisation with testicular antigens, which reproduces the pathology some types human infertility. Activins A and B regulate spermatogenesis steroidogenesis, but are also pro-inflammatory, pro-fibrotic cytokines. Expression activins their endogenous antagonists, inhibin follistatin, was examined in murine EAEO. Adult untreated adjuvant-treated control mice showed no pathology. All immunised...
Experimental autoimmune orchitis (EAO) is a rodent model of chronic testicular inflammation that mimics the pathology observed in some types human infertility. In previous study, expression inflammatory/immunoregulatory cytokine, activin A, was elevated adult mice during onset EAO, indicating potential role regulation disease. Consequently, we examined development EAO with levels follistatin, an endogenous antagonist, as therapeutic approach to inflammation. Prior induction, received single...
Does activin A contribute to testicular fibrosis under inflammatory conditions?Our results show that and key fibrotic proteins are increased in human biopsies with leukocytic infiltrates impaired spermatogenesis murine experimental autoimmune orchitis (EAO) stimulates responses peritubular cells (PTCs) NIH 3T3 fibroblasts.Fibrosis is a feature of EAO. Activin A, regulator fibrosis, was testes mice EAO its expression correlated severity the disease.This cross-sectional longitudinal study...
Abstract 90 Sr is one of the radionuclides released after nuclear accidents that can significantly impact human health in long term. accumulates mostly bones exposed populations. Previous research has shown exposure induces changes bone physiology both humans and mice. We hypothesize that, due to its close location with marrow stromal cells (BMSCs), could induce functional damage may explain these biological effects chronic Sr. The aim this work was verify hypothesis through use an vitro...
Strontium 90 (90Sr) remains in the environment long after a major nuclear disaster occurs. As result, populations living on contaminated land are potentially exposed to daily ingesting of low quantities 90Sr. The potential long-term health effects such chronic contamination unknown. In this study, we used mouse model evaluate 90Sr ingestion immune system, animals were chronically drinking water at concentration 20 kBq/l, for 80–100 Bq/day. This resulted reduced number CD19 B lymphocytes bone...
SUMMARY Rostro-caudal patterning of vertebrates depends on the temporally progressive activation HOX genes within axial stem cells that fuel embryo elongation. Whether sequential activation, “ clock”, is paced by intrinsic chromatin-based timing mechanisms or temporal changes in extrinsic cues remains unclear. Here, we studied clock pacing human pluripotent differentiating into spinal cord motor neuron subtypes which are progenies progenitors. We show caudal progenitors controlled a dynamic...
The aim of this study was to establish an accessible methodology for the objective identification and 3D morphological characterization renal glomeruli in mice. imaging cortex performed by light sheet microscopy on iDISCO+ optical cleared kidneys six C57BL/6J mice after labelling capillary endothelium lectin injection. images were processed with open source software ImageJ, statistical analysis done GraphPad Prism. Non-visual delimitation external surface ensured greyscale-based...
ABSTRACT Testicular cancer is an increasing burden in modern societies and the most common malignancy among young adult males. Environment contaminants, especially endocrine disrupting compounds (EDC), may play a significant role development of these cancers through epigenetic alterations occurring during fetal neonatal development. As long-term studies humans suitable experimental models with potential to develop testicular are lacking, no causal link can be established between disruptor...