A5030211574- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Veterinary medicine and infectious diseases
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Hippo pathway signaling and YAP/TAZ
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
- IL-33, ST2, and ILC Pathways
- RNA regulation and disease
- Enterobacteriaceae and Cronobacter Research
- Cancer Research and Treatments
- Cutaneous lymphoproliferative disorders research
- Cellular Mechanics and Interactions
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- 3D Printing in Biomedical Research
- Retinal Diseases and Treatments
Université de Bordeaux
2011-2024
Bordeaux Population Health
2011-2024
Inserm
2011-2024
Translational Research in Oncology
2019
Cytomegalovirus (CMV) is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved the response to CMV but their role protection has not firmly established and dependency on other lymphocytes addressed. Using C57BL/6 αβ and/or cell-deficient mice, we here show that are as competent protect mice from CMV-induced death. cell-mediated control viral load prevented organ damage. cell recovery by bone marrow transplant or adoptive transfer experiments...
Internal tandem duplication in Fms-like tyrosine kinase 3 (FLT3-ITD) is the most frequent mutation observed acute myeloid leukemia (AML) and correlates with poor prognosis. FLT3 inhibitors are promising for targeted therapy. Here, we investigated mechanisms dampening response to inhibitor quizartinib, which specific hematopoietic niche. Using AML primary samples cell lines, demonstrate that convergent signals from microenvironment drive FLT3-ITD resistance quizartinib through expression...
Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases risk developing AD. We hypothesized H. pylori-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected (n = 15) or felis 13) left uninfected 9) during 18 months. Gastritis, amyloid deposition, astroglial microglial...
Abstract Gastric cancer’s (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs able initiate metastasis. Targeting these aggressive metastasis-initiating CSC (MIC) thus vital. Leukaemia inhibitory factor (LIF) hereby used target Hippo pathway oncogenic members, found induced in features. LIF-treated cell lines, patient-derived xenograft (PDX) and/or tumourspheres underwent...
Antibiotic resistance is a major cause of the increasing failures in current eradication therapies against Helicobacter pylori. In this scenario, repurposing drugs could be valuable strategy to fast-track novel antimicrobial agents. present study, we analyzed inhibitory capability 1,4-dihydropyridine (DHP) antihypertensive on essential function H. pylori response regulator HsrA and investigated both vitro activities vivo efficacy DHP treatments Six different commercially available highly...
Abstract Background Cancer stem cells (CSCs) are at the origin of tumour initiation and progression in gastric adenocarcinoma (GC). However, markers metastasis-initiating remain unidentified GC. In this study, we characterized CD44 variants expressed GC evaluated tumorigenic metastatic properties CD44v3+ their clinical significance patients. Methods Using cell lines patient-derived xenografts, CD44+ molecular signature tumorigenic, chemoresistance, invasive properties, expression...
// Amandine Marine Laur 1, 2, * , Pauline Floch Lucie Chambonnier 2 Benejat 1 Victoria Korolik 3 Alban Giese 4 Pierre Dubus Francis Mégraud Antonio Bandeira 5 Philippe Lehours University Bordeaux, Bacteriology Laboratory, France INSERM U853, Institute for Glycomics, Griffith University, Nathan QLD, Australia EA 2406, Unit Biology of Lymphocyte Populations, Immunology Department, Institut Pasteur and CIMI, Unity Treg Therapy, & Marie Curie, Paris, These authors have contributed...
Unr (officially known as CSDE1) is a cytoplasmic RNA-binding protein with roles in the regulation of mRNA stability and translation. In this study, we identified novel function for Unr, which acts positive regulator placental development. expression studies developing placenta revealed presence Unr-rich foci that are apparently located nuclei trophoblast giant cells (TGCs). We determined what initially thought to be foci, were actually cross sections network double-wall nuclear membrane...
// Emilie Bessède 1, 2 , Silvia Molina Luis Acuña Amador Pierre Dubus 3 Cathy Staedel 4, 5 Lucie Chambonnier Alice Buissonnière Elodie Sifré Alban Giese 3, 9 Bénéjat Benoît Rousseau 6 Costet 7 David B. Sacks 8 Francis Mégraud Christine Varon 1 Bacteriology Laboratory, University of Bordeaux, France INSERM, U853, EA2406 Histologie et pathologie moléculaire des tumeurs, 4 'RNA: Natural and Artificial Regulation' (ARNA) U869, Service Commun Animaleries, Animalerie A2, Transgénique, Department...
Abstract The roles of the inflammatory response and production a proliferation-inducing ligand (APRIL) cytokine in gastric mucosa-associated lymphoid tissue (MALT) lymphomagenesis induced by Helicobacter species infection are not clearly understood. We characterized mucosal associated with MALT lymphoma (GML) identified APRIL-producing cells two model systems: an APRIL transgenic mouse GML (Tg-hAPRIL) human biopsy samples from pylori -infected patients. In model, polarization T helper 1 (...
Neonatal thymectomy in BALB/c mice has been described as a model of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (GML). By using this experimental system, we screened, for the first time to our knowledge, Helicobacter pylori GML-associated strains their capacity promote disease. A cohort underwent at day 3 after birth (d3Tx). Successful thymic ablation was evaluated by degree lymphopenia blood samples collected 4 weeks age. d3Tx and non-thymectomized controls were infected with...
Helicobacter pylori infection is considered as an excellent model of chronic inflammation-induced tumor development. Our project focuses on gastric MALT lymphoma (GML) related to H. and mediated by the inflammatory process initiated infection. Recently, microRNAs (miRNAs) have emerged a new class gene regulators, which play key roles in inflammation carcinogenesis acting oncogenes or suppressors. Their precise characterization development their contribution regulating host cells responses...
There is increasing evidence to support the role of infectious agents in progression Alzheimer's disease (AD), especially Helicobacter pylori (H. pylori). The impact infection on brain non-AD predisposed mice was studied
Gastric cancer is the third leading cause of mortality worldwide. Cancer stem cells (CSC) are at origin tumor initiation, chemoresistance, and formation metastases. However, there a lack mouse models enabling study metastatic process in gastric adenocarcinoma (GC). The aims this were to develop original patient-derived primary GC orthotopic xenografts (PDOX) allowing development distant metastases as preclinical anti-metastatic efficiency drugs such phosphatidylinositol 3-kinase (PI3K)...
The present study describes three putative novel species received at the French National Reference Center for Campylobacters & Helicobacters (CNRCH). CNRCH 2005/566H strain was isolated in 2005 from feces of a patient between 55 and 60 years old with hepatocellular carcinoma gastroenteritis. Strain 48519 2017 blood male suffering bacteremia. Cn23e gastric biopsy dog chronic gastritis. Biochemical growth characteristics electron microscopy these strains were studied. Their genomes also...
Human cytomegalovirus (HCMV) components are often found in tumors, but the precise relationship between HCMV and cancer remains a matter of debate. Pro-tumor functions were described several studies, an association seropositivity reduced risk was also evidenced, presumably relying on recognition killing cells by HCMV-induced lymphocytes. This study aimed at deciphering whether CMV influences development immune-independent manner. Using immunodeficient mice, we showed that systemic infection...