A5088004540- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Salmonella and Campylobacter epidemiology
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Plant Pathogenic Bacteria Studies
- Escherichia coli research studies
- Evolution and Genetic Dynamics
- Animal Nutrition and Physiology
- Enterobacteriaceae and Cronobacter Research
- Galectins and Cancer Biology
- RNA and protein synthesis mechanisms
Université de Bordeaux
2019-2021
Swansea University
2016-2021
Inserm
2019
For the last 500 years, Americas have been a melting pot both for genetically diverse humans and pathogenic commensal organisms associated with them. One such organism is stomach-dwelling bacterium Helicobacter pylori, which highly prevalent in Latin America where it major current public health challenge because of its strong association gastric cancer. By analyzing genome sequence H. pylori isolated North, Central South America, we found evidence admixture between European African origin...
Helicobacter pylori are stomach-dwelling bacteria that present in about 50% of the global population. Infection is asymptomatic most cases, but it has been associated with gastritis, gastric ulcers and cancer. Epidemiological evidence shows progression to cancer depends upon host pathogen factors, questions remain why phenotypes develop a minority infected people. Here, we use comparative genomics approaches understand how genetic variation amongst bacterial strains influences disease...
Campylobacter jejuni is the most common cause of bacterial gastroenteritis worldwide. Mainly isolated from stool samples, C. can also become invasive. belongs to commensal microbiota a number hosts, and infection by this bacterium sometimes be traced back exposure specific source. Here we genome sequenced 200 clinical isolates (2010-2016) analyzed them with 701 isolate genomes human infection, chicken, ruminants environment examine relative contribution different reservoirs non-invasive...
Abstract Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to speciation Homo sapiens. A history pathogen evolution in allopatry has led development genetically distinct H. subpopulations, associated with different populations, and more recent admixture among subpopulations can provide information about migrations. However, little known degree which some genes are conserved face admixture, potentially indicating host adaptation, or how virulence...
Abstract Helicobacter pylori genetic diversity is known to be influenced by mobile genomic elements. Here we focused on prophages, the least characterized elements of H. . We present full sequences, insertion sites and phylogenetic analysis 28 prophages found in isolates from patients distinct disease types, ranging gastritis gastric cancer, geographic origins, covering most continents. The genome sizes these range 22.6–33.0 Kbp, consisting 27–39 open reading frames. A 36.6% GC was contrast...
Measuring molecular evolution in bacteria typically requires estimation of the rate at which nucleotide changes accumulate strains sampled different times that share a common ancestor. This approach has been useful for dating ecological and evolutionary events coincide with emergence important lineages, such as outbreak obligate human pathogens. However, multi-host (niche) transmission scenarios, where pathogen is essentially an opportunistic environmental organism, sampling often sporadic...
The present study describes three putative novel species received at the French National Reference Center for Campylobacters & Helicobacters (CNRCH). CNRCH 2005/566H strain was isolated in 2005 from feces of a patient between 55 and 60 years old with hepatocellular carcinoma gastroenteritis. Strain 48519 2017 blood male suffering bacteremia. Cn23e gastric biopsy dog chronic gastritis. Biochemical growth characteristics electron microscopy these strains were studied. Their genomes also...
Abstract Measuring molecular evolution in bacteria typically requires estimation of the rate at which nucleotide changes accumulate strains sampled different times that share a common ancestor. This approach has been useful for dating ecological and evolutionary events coincide with emergence important lineages, such as outbreak obligate human pathogens. However, multi-host (niche) transmission scenarios, where pathogen is essentially an opportunistic environmental organism, sampling often...
Abstract For the last 500 years, Americas have been a melting pot both for genetically diverse humans and pathogenic commensal organisms associated with them. One such organism is stomach dwelling bacterium Helicobacter pylori , which highly prevalent in Latin America where it major current public health challenge because of its strong association gastric cancer. By analyzing genome sequence H. isolated North, Central South America, we found evidence admixture between European African origin...