A5049615289- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Amoebic Infections and Treatments
- Genomics and Phylogenetic Studies
- Galectins and Cancer Biology
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Escherichia coli research studies
- Epigenetics and DNA Methylation
- Parasitic Infections and Diagnostics
- Veterinary medicine and infectious diseases
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Gut microbiota and health
- Plant Virus Research Studies
- Acute Lymphoblastic Leukemia research
- Kruppel-like factors research
- Viral-associated cancers and disorders
- Plant Pathogenic Bacteria Studies
- Genetic factors in colorectal cancer
- Gene expression and cancer classification
- Cytomegalovirus and herpesvirus research
- Cervical Cancer and HPV Research
Instituto Politécnico Nacional
2016-2025
National Polytechnic School
2023
Universidad Nacional Autónoma de México
2005-2022
National Institute of Genomic Medicine
2013
For the last 500 years, Americas have been a melting pot both for genetically diverse humans and pathogenic commensal organisms associated with them. One such organism is stomach-dwelling bacterium Helicobacter pylori, which highly prevalent in Latin America where it major current public health challenge because of its strong association gastric cancer. By analyzing genome sequence H. pylori isolated North, Central South America, we found evidence admixture between European African origin...
H. pylori (HP) genetics may determine its clinical outcomes. Despite high prevalence of HP infection in Latin America (LA), there have been no phylogenetic studies the region. We aimed to understand structure populations LA mestizo individuals, where gastric cancer incidence remains high. The genome 110 strains from Mexico, Nicaragua and Colombia were analyzed with 59 worldwide available genomes. To study bacterial relationship on whole level we propose a virtual hybridization technique...
Abstract Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to speciation Homo sapiens. A history pathogen evolution in allopatry has led development genetically distinct H. subpopulations, associated with different populations, and more recent admixture among subpopulations can provide information about migrations. However, little known degree which some genes are conserved face admixture, potentially indicating host adaptation, or how virulence...
Klebsiella pneumoniae is recognized as a common cause of nosocomial infections and outbreaks causing pneumonia, septicemia, urinary tract infections. This opportunistic bacterium shows an increasing acquisition antibiotic-resistance genes, which complicates treatment Hence, fast reliable strain typing methods are paramount for the study this pathogen’s multi-drug resistance genetic profiles. In study, thirty-eight strains K. isolated from blood pediatric patients were characterized by...
A series of 3-benzoyl imidazo[1,2-a]pyrimidines, obtained from N-heteroarylformamidines in good yields, was tested silico and vitro for binding inhibition seven Candida species (Candida albicans (ATCC 10231), dubliniensis (CD36), glabrata (CBS138), guilliermondii 6260), kefyr, krusei 6358) tropicalis (MYA-3404)). To predict mode energy, each compound docked the active site lanosterol 14α-demethylase enzyme (CYP51), essential fungal growth species. Antimycotic activity evaluated as 50%...
Our aim in this report was to describe the characteristics of first clinical isolate Escherichia coli (EC-PAG-733) harboring mcr-1 gene found Mexico. This obtained from a fecal sample young child with an oncological condition. We whole-genome sequence using next-generation sequencing and analyzed by bioinformatics tools. EC-PAG-733 resistant third- fourth-generation cephalosporins susceptible all carbapenems amikacin; it also ciprofloxacin, levofloxacin, gentamicin colistin at minimum...
Chagas disease, caused by the protozoan Trypanosoma cruzi, represents a significant public health challenge, particularly in Latin America’s endemic regions. The limited efficacy and frequent adverse effects of current treatments underscore need for novel therapeutic options. This research explores marine natural compounds as potential candidates disease treatment using virtual screening silico evaluation methods. Techniques such molecular docking, drug-likeness evaluation, pharmacokinetic...
Patients with end-stage renal disease (ESRD) are at increased risk of cardiovascular (CVD), such as myocardial infarction (MI). Uremic toxins and endothelial dysfunction central to this process. In exploratory study, we used the Affymetrix GeneChip microarray investigate gene expression profile in uremic serum-induced human coronary arterial cells (HCAECs) from ESRD patients without MI (UWI UWOI groups) an approach its underlying mechanism. We also explored which pathways involved found 100...
To determine the prevalence of human papillomavirus (HPV) infection and genotype distribution in Mexican women with similar lifestyles from two geographical regions who receive medical care Navy Health System, to identify associated sociodemographic reproductive characteristics.Cervical swabs 671 women, beneficiaries distinct southern coast Mexico, were analyzed. Data obtained regarding variables sexual history. For HPV detection typing, PCR general primers direct sequencing performed on...
The unpredictable, evolutionary nature of the influenza A virus (IAV) is primary problem when generating a vaccine and designing diagnostic strategies; thus, it necessary to determine constant regions in viral proteins. In this study, we completed an silico analysis reported epitopes 4 IAV proteins that are antigenically most significant (HA, NA, NP, M2) 3 strains with greatest world circulation last century (H1N1, H2N2, H3N2) one main aviary subtypes responsible for zoonosis (H5N1). For...
Krüppel-like factor 4 (KLF4) is expressed in a variety of tissues with diverse physiological functions and activities. KLF4 can also function as tumor suppressor or an oncogene, depending on the cellular context. Its role hematological malignancies controversial. This study examined expression levels by immunohistochemistry 73 pediatric non-Hodgkin lymphomas (NHLs) tissue microarray several B-NHL cell lines. Elevated were detected 66% lymphoma cases more frequent Burkitt (p = 0.05) subtype....
Abstract Helicobacter pylori (Hp) infects the stomach of about half human population and is strongly associated with risk gastric cancer (GC) its premalignant precursors. The cag pathogenicity island (cagPAI) a region Hp genome encoding for key molecular machinery involved in infection process. Following sequencing study, we selected 50 genetic polymorphisms located seven cagPAI genes tested their associations advanced lesions GC 1220 subjects from various Latin American populations showing...
Abstract Helicobacter pylori (HP) colonizes the human stomach and induces acute gastritis, peptic ulcer disease, atrophic gastric adenocarcinoma. Increased virulence in HP isolates derives from harboring cag (cytotoxin-associated genes) pathogenicity island ( PAI). We analyzed microvariants PAI genes with hypothesis that they may play an important role determining virulence. tested DNAs cagA positive patients isolates; a total of 74 chronic gastritis (CG, N = 37), intestinal metaplasia (IM,...
Abstract Stingless bees (family Apidae; tribe Meliponini), native from Mexico, are essential in tropical ecosystems. They responsible for the pollination of many crops, flora, and honey production. Lactic Acid Bacteria (LAB) a regular host bee microbiota. LAB provide beneficial effects such as decreasing bacterial parasitic pathogens infections enhancing beehive Four different stingless species were sampled southeast Mexico (Veracruz State) identified Melipona beecheii, Scaptotrigona...
Dengue virus (DENV 1-4) represents the major emerging arthropod-borne viral infection in world.Currently, there is neither an available vaccine nor a specific treatment.Hence, need of antiviral drugs for these infections; we describe prediction short interfering RNA (siRNA) as potential therapeutic agents against four DENV serotypes.Our strategy was to carry out series multiple alignments using ClustalX program find conserved sequences among serotype genomes obtain consensus sequence siRNAs...
Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite being associated with human fatalities; it important understand virulence mechanisms and epidemiological prospective cause disease. In study, patient chronic neurologic symptoms presented clinic subsequent isolation strain phenotypic characteristics suggestive Clostridium difficile. However, whole-genome sequence found H. hathewayi. Analysis including...
Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive initial cycles treatment, representing a reservoir emergence clones that display acquired resistance. Although molecular mechanisms DTP have been described, few studies investigated earliest alterations resistance cisplatin. In this work, we report gene expression signature associated with cisplatin-DTP...
Giardiasis is a diarrheal disease that highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; however, failures drug therapy common, and have adverse effects increased resistance parasite to drug, generating need find new alternative treatments. In study, we synthesized series 2-mercaptobenzimidazoles derivatives omeprazole, chemical structures were confirmed through mass, 1H NMR, 13C NMR techniques. The vitro efficacy compounds against...
The aim of this study was to design peptides derived from glycoproteins H (gH) and B (gB) herpes simplex viruses type 1 (HSV-1) 2 (HSV-2) with the potential block herpetic infection evaluate their ability inhibit HSV-1 HSV-2 in vitro.A library continuous 15-25 residue stretches (CRSs) located at surface gH gB created. These CRSs were analyzed, only those that highly flexible rich charged residues selected for antiviral (AVPs). toxicity AVPs evaluated by MTT reduction assays. Virucidal...