A5033379058- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Research and Treatments
- Mesenchymal stem cell research
- FOXO transcription factor regulation
- Hematopoietic Stem Cell Transplantation
- Liver Disease and Transplantation
- Barrier Structure and Function Studies
- Immune cells in cancer
- Lymphatic System and Diseases
- CNS Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Glaucoma and retinal disorders
- Drug-Induced Hepatotoxicity and Protection
- Disaster Response and Management
- Cancer, Hypoxia, and Metabolism
Fred Hutch Cancer Center
2017-2024
Centenary Institute
2009-2017
Cooperative Trials Group for Neuro-Oncology
2014
The University of Sydney
2014
Indian Institute of Chemical Biology
2012
University of Padua
2009
Epithelial-mesenchymal transition (EMT) has been implicated in the processes of embryogenesis, tissue fibrosis and carcinogenesis. Transforming growth factor-β (TGF-β) identified as a key driver EMT plays role pathogenesis cirrhosis hepatocellular carcinoma (HCC). The aim was to identify microRNA (miR) expression TGF-β-induced hepatocyte EMT.We treated human cell line PH5CH8 with TGF-β induce an EMT-like change phenotype then dysregulated miRs using TaqMan Low Density Arrays. MiR altered...
Canonical Hedgehog (Hh) signaling in vertebrate cells occurs following Smoothened activation/translocation into the primary cilia (Pc), followed by a GLI transcriptional response. Nonetheless, activation can occur independently of canonical Hh pathway. Using murine model liver injury, we previously identified importance within Pc+ progenitor cell (LPC) population and noted that SMO-independent, GLI-mediated signals were important multiple Pc-ve GLI2+ intrahepatic populations. This study...
The human ubiquitin C promoter (UBC)-driven GFP-transgenic mouse (UBC-GFP) transgene integration site was mapped recently to chromosome 17, linked closely the MHC locus. In this study, we demonstrate a functional consequence of insertion in backcrossed UBC-GFP BALB/c congenic strain [CByJ.B6-Tg(UBC-GFP) 30Scha/J]: rejection transplanted "syngeneic" 4T1 mammary tumor cells. Rejection BALB/c-derived cells is all likelihood mismatch due stable inheritance C57BL/6-derived H-2b (rather than...