A5009080110- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Telomeres, Telomerase, and Senescence
- Viral-associated cancers and disorders
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Birth, Development, and Health
- Glaucoma and retinal disorders
- CNS Lymphoma Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- IL-33, ST2, and ILC Pathways
- Synthesis and Characterization of Heterocyclic Compounds
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Metal Forming Simulation Techniques
- Cervical Cancer and HPV Research
Inserm
2016-2023
Université de Bordeaux
2010-2023
Bordeaux Population Health
2016-2023
Translational Research in Oncology
2021
Objectives Recent studies have shown that telomere length was significantly reduced in placentas collected at delivery from pregnancies complicated by intrauterine growth restriction secondary to placental insufficiency. Placental measurement during ongoing has never been reported. This the main objective of our study. Methods In center, late chorionic villus samplings were performed between 18 and 37 weeks amenorrhea 24 subjects with severe (cases) 28 other indications for prenatal...
Monoallelic 6p25.3 rearrangements associated with DUSP22 (Dual Specificity Phosphatase 22) gene silencing have been reported in CD30+ peripheral T-cell lymphomas (PTCL), mostly anaplastic morphology and of cutaneous origin. However, the mechanism second allele putative tumor suppressor function not investigated so far. Here, we show that presence, most individuals, an inactive paralog hampers genetic epigenetic evaluation gene. Identification DUSP22-specific single-nucleotide polymorphisms...
Abstract Background Telomere shortening is linked to a range of different human diseases, hence reliable measurement methods are needed uncover such associations. Among the plethora telomere length methods, qPCR reported as easy conduct and cost‐effective approach study samples with low DNA amounts. Methods Cancer cells’ was evaluated by relative absolute methods. Results Robust reproducible measurements were optimized taking into account careful reference gene selection knowing cancer cells...
Cutaneous T-cell lymphomas (CTCLs) are telomerase-positive tumors expressing hTERT, although neither gene rearrangement/amplification nor promoter hotspot mutations could explain the hTERT re-expression. As is rich in CpG, we investigated contribution of epigenetic mechanisms its We analyzed methylation status CTCL cells compared with healthy cells. Gene-specific analyses revealed a common pattern exclusively tumor This encompassed hypermethylated distal region from -650 to -150 bp and...
Neurofibromatosis 1 (NF1) is one of the most common genetic disorders and caused by mutations in NF1 gene. gene mutational analysis presents a considerable challenge because its large size, existence highly homologous pseudogenes located throughout human genome, absence hotspots, diversity types, including deep intronic splicing mutations. We aimed to evaluate use hybridization capture-based next-generation sequencing screen coding noncoding regions. Hybridization sequencing, with genomic...
As a major cancer hallmark, there is sustained interest in understanding the telomerase contribution to carcinogenesis order therapeutically target this enzyme. This particularly relevant primary cutaneous T-cell lymphomas (CTCL), malignancy showing dysregulation with few investigative data available. In CTCL, we examined mechanisms involved transcriptional activation and activity regulation. We analyzed 94 CTCL patients from Franco-Portuguese cohort, as well 8 cell lines, comparison 101...
// Pauline Floch 1,2,* , Amandine Marine Laur Victoria Korolik 3 Delphine Chrisment 1,2 David Cappellen 4 Yamina Idrissi Pierre Dubus Francis Mégraud and Philippe Lehours 1 University of Bordeaux, Bacteriology Laboratory, F-33000 France 2 Inserm U853, Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia EA 2406, * These authors have contributed equally to this work Correspondence to: Lehours, email: Keywords : cytokines, chemokines, MALT lymphoma, TNF, animal model...
Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL) in which the human Telomerase Reverse Transcriptase (hTERT) gene re-expressed. Current available treatments do not provide long-term response. We previously reported that Histone deacetylase inhibitors (HDACi, romidespin and vorinostat) a DNA methyltransferase inhibitor (DNMTi, 5-azacytidine) can reduce hTERT expression without altering methylation level promoter. Romidepsin vorinostat are approved...
The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines 12 and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines 13 are reported here in six steps starting from various halogeno-quinazoline-2,4-(1H,3H)-diones or substituted anilines. antiproliferative activities the products were determined vitro against a panel breast (MCF-7 MDA-MB-231), human adherent cervical (HeLa SiHa), ovarian (A2780) cell lines. Disubstituted 6-...
Primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT) is a rare and aggressive malignancy, mostly occurring on the leg of elderly women (Willemze et al., 2019). PCDLBCL-LT harbors an activated B-cell‒like lymphoma (ABC-DLBCL) signature enriched for mutations involving toll-like receptor, NF-κB pathways (Pham-Ledard 2012; Zhou 2018). The high frequency MYD88L265P mutation in combination with those CD79B PIM1 relates these lymphomas to MCD/C5 subset lymphomas, which includes...