A5046497860- Diet and metabolism studies
- Gut microbiota and health
- Nutrition, Genetics, and Disease
- HIV Research and Treatment
- Cancer Research and Treatments
- Digestive system and related health
- Neuroinflammation and Neurodegeneration Mechanisms
- Herpesvirus Infections and Treatments
- Peripheral Neuropathies and Disorders
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Dietary Effects on Health
- Virology and Viral Diseases
- Immune cells in cancer
- Infant Health and Development
- Nutrition and Health in Aging
- Mosquito-borne diseases and control
- Hormonal and reproductive studies
- Milk Quality and Mastitis in Dairy Cows
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Muscle Physiology and Disorders
- Neuroendocrine regulation and behavior
- Advancements in Transdermal Drug Delivery
- Sperm and Testicular Function
Massachusetts Institute of Technology
2013-2018
Boston College
2015-2017
Temple University
2017
University of California, San Diego
2017
Beth Israel Deaconess Medical Center
2017
Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes some types cancer. Impact the microbiome upon mammalian wound process poorly understood. We discover that supplementing gut lactic acid microbes in drinking water accelerates wound-healing occur half time required for matched control animals. Further, we find Lactobacillus reuteri enhances properties through up-regulation neuropeptide...
Radiant skin and hair are universally recognized as indications of good health. However, this 'glow health' display remains poorly understood. We found that feeding probiotic bacteria to aged mice induced integumentary changes mimicking peak health reproductive fitness characteristic much younger animals. Eating yogurt triggered epithelial follicular anagen-phase shift with sebocytogenesis resulting in thick lustrous fur due a bacteria-triggered interleukin-10-dependent mechanism. Aged male...
A recent epidemiological study showed that eating 'fast food' items such as potato chips increased likelihood of obesity, whereas yogurt prevented age-associated weight gain in humans. It was demonstrated previously animal models obesity the immune system plays a critical role this process. Here we examined human subjects and mouse consuming Westernized diet, found CD4+ T helper (Th)17-biased immunity changes microbial communities abdominal fat with after Western chow. In striking contrast,...
The decline of circulating testosterone levels in aging men is associated with adverse health effects. During studies probiotic bacteria and obesity, we discovered that male mice routinely consuming purified lactic acid originally isolated from human milk had larger testicles increased serum compared to their age-matched controls. Further investigation using microscopy-assisted histomorphometry testicular tissue showed Lactobacillus reuteri drinking water significantly seminiferous tubule...
Recent studies suggest health benefits including protection from cancer after eating fermented foods such as probiotic yogurt, though the mechanisms are not well understood. Here we tested mechanistic hypotheses using two different animal models: first model studied development of mammary when a Westernized diet, and second animals with genetic predilection to breast cancer. For model, outbred Swiss mice were fed chow putting them at increased risk for tumors. In this diet carcinogenesis was...
Muscle wasting, known as cachexia, is a debilitating condition associated with chronic inflammation such during cancer. Beneficial microbes have been shown to optimize systemic inflammatory tone good health; however, interactions between and host immunity in the context of cachexia are incompletely understood. Here we use mouse models test roles for bacteria muscle wasting syndromes. We find that feeding human commensal microbe, Lactobacillus reuteri, mice sufficient lower indices inhibit...
// Jessica R. Lakritz 1 , Theofilos Poutahidis 1, 2 Sheyla Mirabal Bernard J. Varian Tatiana Levkovich Yassin M. Ibrahim Jerrold Ward 3 Ellen C. Teng Brett Fisher Nicola Parry Stephanie Lesage Natalie Alberg Sravya Gourishetti James G. Fox Zhongming Ge Susan E. Erdman Division of Comparative Medicine, Massachusetts Institute Technology, Cambridge, MA 02139, USA Laboratory Pathology, Faculty Veterinary Aristotle University Thessaloniki, Greece 54124 Global VetPathology, Montgomery Village, MD...
Abstract Environmental factors are suspected in the increase of obesity and cancer industrialized countries but poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences grandmothers' utero dietary exposures, leading high rates frequent cancers lung liver two subsequent mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding...
Objective: Higher plasma soluble cluster of differentiation (CD)163 (sCD163), shed by monocytes and macrophages, correlates with neurocognitive impairment in HIV infection. We hypothesized that higher antemortem or cerebrospinal fluid (CSF) sCD163 would be associated greater postmortem neurodegeneration and/or microgliosis. Design: Retrospective, observational study. Methods: measured levels (n = 54) CSF 32) samples from 74 HIV-seropositive participants (median 5 months before death) who...
Peripheral neuropathy (PN) continues to be a major complication of human immunodeficiency virus (HIV) infection despite successful anti-retroviral therapy. Human HIV-PN can recapitulated in CD8-depleted, simian (SIV)-infected rhesus macaque animal model, characterized by loss intraepidermal nerve fiber density (IENFD) and damage the dorsal root ganglia (DRG). Increased monocyte traffic DRG has previously been associated with severe pathology, as well IENFD. Here, we sought characterize...
Abstract Background Zika virus (ZIKV) was first isolated from a sentinel rhesus monkey in 1947. ZIKV infection humans is associated with serious neurological and reproductive complications. No antiviral or protective vaccine yet available. Galidesivir an adenosine analog potent viral RNA-dependent RNA polymerase inhibitor demonstrated broad-spectrum activity. Methods We have conducted four pre-clinical studies macaques to assess the safety, efficacy dosing strategies of galidesivir against...
<div>Abstract<p>Environmental factors are suspected in the increase of obesity and cancer industrialized countries but poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences grandmothers' <i>in utero</i> dietary exposures, leading high rates frequent cancers lung liver two subsequent mice. Transgenerational effects were transplantable using diet-associated bacteria...
<div>Abstract<p>Environmental factors are suspected in the increase of obesity and cancer industrialized countries but poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences grandmothers' <i>in utero</i> dietary exposures, leading high rates frequent cancers lung liver two subsequent mice. Transgenerational effects were transplantable using diet-associated bacteria...
<p>L. reuteri dietary enrichment protects the F1 progeny of NWD-fed mothers from transgenerational cancer. Pulmonary adenocarcinoma, hepatocellular carcinoma and mesenteric lymph node lymphoma in children consuming NWD are shown left column. Compare with normal lung, liver histology mice similar descend that were also treated L. reuteri.</p>
<p>Control and NWD-treated mice cluster separately by microbiota. carry fewer Bacteroidetes in general than their control diet-fed counterparts. Overall, there is a shift towards higher abundance of OTUs from the Firmicutes phyla decrease treated with NWD. These data are consistent previous findings elevation to obese mice.</p>