A5101506181- Inflammatory Bowel Disease
- RNA modifications and cancer
- Biomedical Text Mining and Ontologies
- Protist diversity and phylogeny
- scientometrics and bibliometrics research
- Biological and pharmacological studies of plants
- Ferroptosis and cancer prognosis
- Microscopic Colitis
- Microbial Community Ecology and Physiology
- Semantic Web and Ontologies
- Plant and animal studies
- Cancer-related molecular mechanisms research
- Pregnancy and Medication Impact
- Parasitic Infections and Diagnostics
- Bioinformatics and Genomic Networks
- Health and Medical Research Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Helminth infection and control
- Gastrointestinal motility and disorders
- Economic and Financial Impacts of Cancer
- Ginseng Biological Effects and Applications
- IL-33, ST2, and ILC Pathways
Anhui Medical University
2024-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Hebei North University
2024
Ocean University of China
2022-2024
Hebei General Hospital
2024
Guangzhou University of Chinese Medicine
2020-2023
China Agricultural University
2021-2022
East China University of Science and Technology
2019
Huazhong University of Science and Technology
2013-2017
Chengdu University of Traditional Chinese Medicine
2016
There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary set up corresponding lncRNA signatures. The expression profiles lncRNAs which contained 480 adenocarcinoma samples obtained from Cancer Genome Atlas (TCGA) database. coexpression network and genes utilized select lncRNAs. further screened using univariate Cox regression. In addition, Lasso regression multivariate...
Ciliates in the subclass Hypotrichia have long been difficult to classify as they are one of most polymorphic and highly differentiated groups, leading their systematics remaining unresolved. Phylogenetic relationships within hypotrich family Strongylidiidae ambiguous due discordance between morphological genetic data. In this study, a new strongylidiid genus
Cryptosporidium parvum is an intracellular protozoan that can cause severe diarrhea in humans and various mammals. Results of a comparative genomic analysis indicated genes encoding two C. parvum-specific insulinase-like proteases (INS19 INS20), cgd6_5510 cgd6_5520, are lost many species. In this study, we provided evidence indicating cgd6_5520 fragments full gene (cgd6_5520-5510) one protease (INS20-19) similar structure to classic insulinases. We expressed Escherichia coli for antiserum...
Hepatocellular carcinoma (HCC) is one of the most universal malignant liver tumors worldwide. However, there were no systematic studies to establish glycolysis‑related gene pairs (GRGPs) signatures for patients with HCC. Therefore, study aimed novel GRGPs better predict prognosis HCC.Based on data from Gene Expression Omnibus, The Cancer Genome Atlas (TCGA) and International Consortium databases, glycolysis-related mRNAs used construct GRGPs. Cox regression was applied a seventeen signature...
Aim: To investigate the effect of hair follicle mesenchymal stem cells (HFMSCs) in ischemic stroke. Materials & methods: Rat transient stroke model was established to verify HFMSC transplantation. Behavioral experiment and TTC staining were used estimate neurological outcome after therapy. Pathological experiments therapeutic roles HFMSCs. Results: HFMSCs inhibited neural apoptosis promoted proliferation. The number around core increased Besides, grafted expressed neuron-specific marker...
This study aimed to evaluate the current status and discrepancies between anticipated actual involvement in decision-making roles among patients with inflammatory bowel disease, as well explore factors that influenced participation. From December 2023 June 2024, a convenience sampling method was employed recruit disease from Department of Gastroenterology at tertiary hospital Anhui, China. A general information questionnaire, Control Preference Scale, All Aspects Health Literacy Decision...
Abstract Background Translational medical research literature has increased rapidly in the last few decades and played a more important role during development of medicine science. The main aim this study is to evaluate global performance translational past decades. Methods Bibliometric, social network analysis, visualization technologies were used for analyzing from aspects subject categories, journals, countries, institutes, keywords, MeSH terms. Meanwhile, co-author, co-words cluster...
The aim of this study is to analyze the research trends medical informatics over last 12 years. A new method based on MeSH terms was proposed identify emerging topics and research. Informetric methods visualization technologies were applied investigate informatics. metric perspective factor (PF) embedding appropriately employed assess quality for journals. have changed dramatically years, identifying two stages informatics: "medical imaging stage" stage". focus has shifted from acquisition...
Background & objectives: Artemisinin was first extracted from the herb Artemisia annua which has been used for many centuries in Chinese traditional medicine as a treatment fever and malaria. It given 2011 Lasker-DeBakey clinical medical research award. In this paper, knowledge map of artemisinin drawn to provide some information global researchers interested its relevant references. Methods: work, bibliometric analysis visualization technology were applied evaluate scientific production...
Abstract Background Myasthenia gravis (MG) is an acquired autoimmune disease with high heterogeneity. The chronic, relapsing repeatedly and progressive acute exacerbation occasionally. Although the treatment of MG has developed, it still unsatisfactory some unexpected side effects. Traditional Chinese medicine (TCM) shown great potential in treatment, including relief muscle weakness syndrome, improvement patient’s quality life, reduction effects western medicine. purpose this study to...
Abstract Background Modified Sijunzi decoction (SJZD) has been used to treat ulcerative colitis (UC) in remission. However, more rigorous clinical trials are necessary evaluate its effectiveness. Therefore, a series of single-case randomised controlled ( N -of-1 trials) is proposed compare the efficacy modified SJZD with mesalazine for treating UC Methods This single-site, hospital-based, double-blind trial 10 single subjects. Three cycles planned. There two treatment periods each cycle....
Background: The pathogenesis of ulcerative colitis (UC) is closely related to immunity. immune characteristic differences between active UC (UCa) and inactive (UCin) have not been completely explained. Mass cytometry (CyTOF) single-cell RNA sequencing (scRNA-seq) were used analyze the cells UCa, UCin healthy control (HC) subjects determine specific characteristics. Methods: cell subsets among UCin, HC distinguished using CyTOF analysis. scRNA-seq analysis was validate results CyTOF. Gene...
Subtype families of Cryptosporidium parvum differ in host range, with IIa and IId being found a broad range animals, IIc humans, IIo IIp some rodents. Previous studies indicated that the subtelomeric cgd6_5520-5510 gene C. is lost many species, could potentially contribute to former. In this study, we identified presence second copy subtype showed sequence differences among them. The were not segregated by type 60 kDa glycoprotein gene. Genetic recombination appeared have played role...
Purpose Merkel cell carcinoma (MCC) is a neuroendocrine originating in the skin. Studies are needed to determine mechanisms of immune escape patients with MCC, and malignant conditions that promote evasion. Methods We used Single-cell RNA sequencing (scRNA-seq) cellular features associated MCC disease trajectory. A longitudinal multi-omics study was performed using scRNA-seq data peripheral blood harvested from four-time points. Six major types fifteen subgroups were identified confirmed...
Background: This study aimed to explore the experience of financial toxicity in patients with colorectal cancer during chemotherapy and inform development targeted interventions. Methods: A descriptive qualitative research method was used conduct semi-structured interviews a purposive sample 15 undergoing who attended Department Medical Oncology First Affiliated Hospital Anhui University from March June 2024, data were organized analyzed using Nvivo 11.0 analysis software thematic method....
Inflammatory bowel disease (IBD) has become a global public health problem. The prevalence of IBD in China increased annually past two decades.This study was to translate and validate the rating form patients' concerns (RFIPC), describe disease-related worries patients with IBD. simplified Chinese version RFIPC developed according translation back-translation procedure. Patients were consecutively enrolled from First Affiliated Hospital Guangzhou University Medicine. participants assessed...
Abstract Background: Dendrobium officinale Kimura et Migo is a traditional functional food and medicinal plant in China. Due to low natural regeneration rates, habitat destruction, excessive collection commercial trade, D. severely threatened, artificial-sheltered cultivation has been massively used meet the needs of market. Aim: To comprehensively compare accumulation nutritional compounds during 3-5 years introduced, from southern northern Methods: same species were artificially cultivated...