A5070380014- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 and COVID-19 Research
- Parasites and Host Interactions
- Asthma and respiratory diseases
- SARS-CoV-2 detection and testing
- Parasitic Infections and Diagnostics
- Underwater Acoustics Research
- Study of Mite Species
- Phytoplasmas and Hemiptera pathogens
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Machine Fault Diagnosis Techniques
- Vitamin D Research Studies
- Mosquito-borne diseases and control
- Antimicrobial agents and applications
- Environmental Sustainability and Education
- Blind Source Separation Techniques
- Respiratory viral infections research
- Virus-based gene therapy research
- Insects and Parasite Interactions
- COVID-19 Clinical Research Studies
- Contact Dermatitis and Allergies
Universidade Federal da Bahia
2021-2025
Serviço Nacional de Aprendizagem Industrial
2023-2024
Hospital Ana Nery
2022
Faculdades Oswaldo Cruz
2020
Allergen-specific immunotherapy (AIT) is the only clinical approach that can potentially cure some allergic diseases by inducing immunological tolerance. Dermatophagoides pteronyssinus considered as most important source of mite allergens worldwide, with high sensitization rates for major Der p 1, 2 and 23. The aim this work to generate a hypoallergenic hybrid molecule containing T-cell epitopes from these three allergens.The protein termed 2231 was purified affinity chromatography. human...
The COVID-19 pandemic and the consequent emergence of new SARS-CoV-2 variants concern necessitates determination populational serum potency against virus. Here, we standardized validated an imaging-based method to quantify neutralizing antibodies lentiviral particles expressing spike glycoprotein (pseudovirus). This was found efficiently viral titers based on ZsGreen-positive cells detect changes in human neutralization capacity induced by vaccination with up two doses CoronaVac, Comirnaty,...
Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment approach to change disease-causing allergens. Hypoallergenic derivatives show promise as potential therapeutics, amongst which BTH2 was designed induce tolerance against Blomia tropicalis allergy. Our aim investigate hypoallergenicity and immunoregulatory activity of in vitro its therapeutic a mouse model AIT.Recombinant Blo t 5 21 allergens their hybrid (BTH1 BTH2) were expressed purified. IgE binding capacity...
Immune imprinting is now evident in COVID-19 vaccinated people. This phenomenon may impair the development of effective neutralizing antibodies against variants concern (VoCs), mainly Omicron and its subvariants. Consequently, boost doses with bivalent vaccines have not shown a significant gain function regarding neutralization Omicron. The approach to design must be revised improve effectiveness VoCs. Here, we took advantage self-amplifying characteristic RepRNA developed polyvalent...
Toxocariasis is an infection caused by the round worms Toxocara canis and cati. It occurs worldwide though it more prevalent in developing countries. For diagnosis of toxocariasis, most used method indirect enzyme-linked immunosorbent assay (indirect ELISA), based on detection specific antibodies using excreted/secreted products from T. larvae (TES) as antigens, but cross-reacts with several helminth infections. this reason, there a need to investigate species-specific immunoreactive...
This study was conducted using data from the SCAALA (Social Change Asthma and Allergy in Latin America) cohort Brazil 2005 to 2013. We examined seroprevalence risk factors of toxocariasis, a parasitic infection leading conditions such as visceral larva migrans, utilizing an indirect ELISA with T. canis antigens, alongside questionnaires, eosinophil counts, sIgE aeroallergens, IL-10 levels, Skin Prick Test results; research provided insights into disease’s dynamics. The prevalence...
Empirical mode decomposition (EMD) is a signal processing method that produces data-driven time-frequency representation suited to characterize time-varying and nonlinear phenomena. In EMD, intrinsic functions (IMF) are sequentially estimated from the of interest represent different oscilation modes produce an orthogonal original information. Different algorithms have been proposed for EMD estimation deal with limitations such as mode-mixing noise sensitivity. To obtain frequency-domain...
(1) Background: Modification of the structural elements allergens is widely used in field allergies. The goal present research was to express, purify, and characterize shortened recombinant group 5 allergen Dermatophagoides pteronyssinus (rDer p 5). (2) Methods: rDer storage stability aggregation capacity were explored through silico analysis, dynamic light scattering (DLS), SDS-PAGE. Serum IgE reactivity cytokine amount investigated sera or cell culture supernatants ELISA, MULTIPLEX®,...