A5068458966- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Cancer-related Molecular Pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Arsenic contamination and mitigation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aluminum toxicity and tolerance in plants and animals
- Per- and polyfluoroalkyl substances research
- Microplastics and Plastic Pollution
- Immune Response and Inflammation
- Recycling and Waste Management Techniques
- Toxic Organic Pollutants Impact
- RNA Research and Splicing
- MicroRNA in disease regulation
- Heat shock proteins research
- Biochemical effects in animals
- Air Quality and Health Impacts
- Alzheimer's disease research and treatments
- Bioactive natural compounds
- interferon and immune responses
- NF-κB Signaling Pathways
- Barrier Structure and Function Studies
- Metabolomics and Mass Spectrometry Studies
- Ginger and Zingiberaceae research
Nantong University
2014-2025
Taizhou University
2020-2023
Fudan University
2020-2023
Zhongshan Hospital
2022
Nantong Science and Technology Bureau
2019
Affiliated Hospital of Nantong University
2011-2013
Nanoplastics are common contaminants in the living environment. Thus far, no investigations have focused on small intestinal injury offspring of adult mice that were exposed to nanoplastics through respiratory system during pregnancy. Here, we evaluated potential subjected maternal 80 nm polystyrene nanoparticle (PS-NP) exposure gestation. PS-NP significantly reduced birth weight female compared with male mice. However, body weights and substantially greater PS-NP-exposed groups....
Exposure to antimony (Sb), recently identified as a nerve pollutant, can result in neuron damage; but, associated-neurotoxicological mechanisms were still not clear. Herein, we assessed the role of ferroptosis Sb-mediated neurotoxicity and clarified underlying mechanism. Following Sb exposure, was significantly promoted vivo vitro. Moreover, following use ferrostatin-1 (fer-1) inhibit ferroptosis, Sb-induced PC12 cells effectively attenuated. accelerated lysosomal transport subsequent...
Background Epidemiological evidence on Urine metals and cognitive impairment in older individuals is sparse limited. The goal of this study was to analyze if there a link between urinary metal levels performance U.S. people aged 60 up. Methods National Health Nutrition Examination Survey (NHANES) data from 2011 2014 were utilized cross-sectional analysis. Memory function quantified using the following methods: Established Consortium for Word Learning Alzheimer's Disease (CERAD-WL) (immediate...
Organically modified silica (ORMOSIL) nanoparticles (NPs) are widely used in biomedicine. However, their cell uptake process has not yet been characterised detail. Here, we investigated the mechanism underlying endocytosis and subcellular localisation of ORMOSIL NPs. Exposure to NPs induced a decrease viability increase lactate dehydrogenase release dose-dependent manner A549 cells. Once internalised, were translocated from early endosomes lysosomes, where they accumulated. Furthermore,...
Short-chain chlorinated paraffins (SCCPs) are novel toxicants in food and reported to possess neurotoxicity. Here, we investigated the mechanism of SCCP-induced astrocyte activation neuroinflammation. SCCP gavage induced neuronal cell death with changes gut microbiome metabolites. Antibiotic cocktail administration deplete ameliorated inflammation by SCCPs. In fecal microbiota transplantation (FMT) assays, mice that received transplanted from SCCP-treated showed increased elevated...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental pollutant that could induce significant toxic effects in the human nervous system. However, underlying molecular mechanism has not been entirely elucidated. Reactive astrogliosis implicated various neurological diseases via production of variety pro-inflammatory mediators. Herein, we investigated potential role TCDD facilitating astrocyte activation and mechanisms. We showed induced rapid following exposure, which was...