A5014835191- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Substance Abuse Treatment and Outcomes
- Transcranial Magnetic Stimulation Studies
- Phonetics and Phonology Research
- Hearing Loss and Rehabilitation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Obsessive-Compulsive Spectrum Disorders
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Speech Recognition and Synthesis
- Genetic Syndromes and Imprinting
- Neuroscience and Music Perception
- Atomic and Subatomic Physics Research
- MRI in cancer diagnosis
- Schizophrenia research and treatment
Technische Universität Dresden
2015-2025
University Hospital Carl Gustav Carus
2011-2023
MSB Medical School Berlin
2022
University of Tübingen
2022
Justus-Liebig-Universität Gießen
2022
Charité - Universitätsmedizin Berlin
2022
University Medical Center
2022
University Hospital Frankfurt
2022
Goethe University Frankfurt
2022
École Polytechnique Fédérale de Lausanne
2021
Individuals with anorexia nervosa are thought to exert excessive self-control inhibit primary drives.This study used functional MRI (fMRI) interrogate interactions between the neural correlates of cognitive control and motivational processes in brain reward system during anticipation monetary reward-related feedback. In order avoid confounding effects undernutrition, we studied female participants recovered from closely matched healthy controls. The fMRI analysis (including node-to-node...
Abstract Substance use disorders (SUDs) are seen as a continuum ranging from goal‐directed and hedonic drug to loss of control over intake with aversive consequences for mental physical health social functioning. The main goals our interdisciplinary German collaborative research centre on Losing Regaining Control Drug Intake (ReCoDe) (i) study triggers (drug cues, stressors, priming) modifying factors (age, gender, activity, cognitive functions, childhood adversity, factors, such loneliness...
Obtaining three-dimensional geometrical data of vascular systems is major importance to a number research areas in medicine and biology. Examples are the characterization tumor vasculature, modeling blood flow, or genetic effects on development. The performance General Electric Medical Systems MS8 microCT scanner examined context these applications. system designed acquire high-resolution images specimens up 5 cm diameter. A maximum resolution 38 lp/mm at 10% modulation transfer function...
Within the field of functional magnetic resonance imaging (fMRI) neurofeedback, most studies provide subjects with instructions or suggest strategies to regulate a particular brain area, while other neuro-/biofeedback approaches often do not. This study is first investigate hypothesis that are able utilize fMRI neurofeedback learn differentially modulate signal from bilateral amygdala congruent prescribed regulation direction without an instructed suggested strategy and apply what they...
Abstract Thyroid hormones play a critical role in brain development but also the adult human by modulating metabolic activity. Hypothyroid states are associated with both functional and structural alterations seen patients major depression. Recent animal experimental preclinical data indicate subtle changes myelination, microvascular density, local neurogenesis, networks. The translational validity of such studies is obviously limited. Clinical evidence for neurobiological correlates...
While a number of studies have established that moderate doses alcohol increase brain perfusion, the time course such an as function breath concentration (BrAC) has not yet been investigated, and differ about regional effects. Using arterial spin labeling (ASL) magnetic resonance imaging, we investigated (1) perfusion during 15-minute linear BrAC up to 0.6 g/kg followed by steady exposure 100 minutes, (2) distribution, (3) potential gender effect, (4) temporal stability In 48 young adults...
Abstract Background Gray matter (GM) ‘pseudoatrophy’ is well-documented in patients with anorexia nervosa (AN), but changes white (WM) are less well understood. Here we investigated the dynamics of microstructural WM brain AN during short-term weight restoration a combined longitudinal and cross-sectional study design. Methods Diffusion-weighted images were acquired young before (acAN-Tp1, n = 56) after (acAN-Tp2, 44) as age-matched healthy controls (HC, 60). Images processed using...
Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic AC need be informed by real-world evidence.To examine whether lockdown measures are associated with consumption-related temporal psychological within-person mechanisms.This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites February 20, 2020, 28, 2021. Data were provided before within second in Germany: (October...
Abstract Background Individuals with bipolar disorder are commonly correctly diagnosed a decade after symptom onset. Machine learning techniques may aid in early recognition and reduce the disease burden. As both individuals at risk those manifest display structural brain markers, magnetic resonance imaging provide relevant classification features. Methods Following pre-registered protocol, we trained linear support vector machine (SVM) to classify according their estimated for using...
Abstract The prefrontal‐limbic network in the human brain plays a major role social cognition, especially cognitive control of emotion. medial frontopolar cortex (mFP; Brodmann Area 10) and amygdala are part this display correlated neuronal activity time, as measured by functional magnetic resonance imaging (fMRI). This connectivity is dynamic, sensitive to training, affected mental disorders. However, effects neurostimulation on within have not yet been systematically investigated. Here, we...
Abstract In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite similar disease burden, populations at risk bipolar disorder not sufficiently characterized. Within BipoLife consortium, we used magnetic resonance imaging (MRI) data from multicenter study assess structural gray matter alterations in N = 263 help-seeking individuals seven sites. We...
The pathophysiology of bipolar disorder (BD) remains mostly unclear. Yet, a valid biomarker is necessary to improve upon the early detection this serious disorder. Patients with manifest BD display reduced volumes hippocampal subfields and amygdala nuclei. In pre-registered analysis, we used structural MRI (n = 271, 7 sites) compare hippocampus, their subfields/nuclei between help-seeking subjects divided into risk groups for as estimated by BPSS-P, BARS EPIbipolar. We performed...
Reliability of imaging parameters is pivotal importance for further correlation analyses. Here, we investigated the test-retest reliability two dynamic functional connectivity (dFC) brain states and related different scan length, atlases with 116 versus 442 regions, data centering in 23 participants reproduced findings 501 subjects Human Connectome Project. Results showed an integrated a segregated state high intraclass coefficient (ICC) values between sessions (0.67 ≥ ICC 0.99). The most...
Nearly all functional magnetic resonance imaging (fMRI) studies are conducted in the supine body posture, which has been discussed as a potential confounder of such examinations. The literature suggests that cognitive functions, problem solving or perception, differ between and upright postures. However, effect posture on many functions is still unknown. Therefore, aim present study was to investigate effects (supine vs. sitting) one most frequently used paradigms sciences: N-back working...
Abstract Background Resting state functional magnetic resonance imaging studies have identified connectivity patterns associated with acute undernutrition in anorexia nervosa (AN), but few investigated recovered patients. Thus, a trait profile characteristic of the disorder remains elusive. Using state-of-the-art graph–theoretic methods AN, authors previously found abnormal global brain network architecture, possibly driven by local alterations. To disentangle from starvation effects,...
It is well established that even moderate levels of alcohol affect cognitive functions such as memory, self-related information processing, and response inhibition. Nevertheless, the neural mechanisms underlying these alcohol-induced changes are still unclear, especially on network level. The default mode (DMN) plays an important role in memory self-initiated mental activities; hence, studying functional interactions DMN may provide new insights into alcohol-related changes.We investigated...