A5022442631- Forensic and Genetic Research
- Milk Quality and Mastitis in Dairy Cows
- Pleistocene-Era Hominins and Archaeology
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Cuban History and Society
- Genetic diversity and population structure
- Gut microbiota and health
- Forensic Anthropology and Bioarchaeology Studies
- Genetic and phenotypic traits in livestock
- Archaeology and ancient environmental studies
- Genetic Associations and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Genomics and Phylogenetic Studies
- Evolution and Paleontology Studies
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Archaeological and Geological Studies
- HIV/AIDS oral health manifestations
Universidad Nacional Autónoma de México
2020-2023
Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico's Indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions private variants functional biomedical relevance. Here we targeted the coding fraction characterized its full site frequency spectrum by 76 exomes from five populations across Mexico. Using diffusion approximations,...
After the European colonization of Americas, there was a dramatic population collapse Indigenous inhabitants caused in part by introduction new pathogens. Although is much speculation on etiology Colonial epidemics, direct evidence for presence specific viruses during era lacking. To uncover diversity viral pathogens this period, we designed an enrichment assay targeting ancient DNA (aDNA) from clinical importance and applied it to extracts individuals found hospital chapel (16th–18th...
Aridoamerica and Mesoamerica are two distinct cultural areas in northern central Mexico, respectively, that hosted numerous pre-Hispanic civilizations between 2500 BCE 1521 CE. The division these regions shifted southward because of severe droughts ~1100 years ago, which allegedly drove a population replacement Mexico by Aridoamerican peoples. In this study, we present shotgun genome-wide data from 12 individuals 27 mitochondrial genomes eight archaeological sites across including at the...
The ‘red complex’ is an aggregate of three oral bacteria ( Tannerella forsythia , Porphyromonas gingivalis and Treponema denticola ) responsible for severe clinical manifestation periodontal disease. Here, we report the first direct evidence ancient T. DNA in dentin dental calculus samples from archaeological skeletal remains that span Pre-Hispanic to Colonial period Mexico. We recovered twelve partial genomes observed a distinct phylogenetic placement samples, suggesting strains present...
Abstract We study the gene MUC19, for which modern humans carry a Denisovan-like haplotype. MUC19 is mucin, glycoprotein that forms gels with various biological functions. find diagnostic variants haplotype at high frequencies in admixed Latin American individuals among global populations, and highest frequency 23 ancient Indigenous individuals, all predating population admixture Europeans Africans. carries higher copy number of 30 base-pair variable tandem repeat, numbers this repeat are...
Abstract Although Brazil was inhabited by more than 3,000 Indigenous populations prior to European colonization, today’s peoples represent less 1% of Brazil’s census population. Some the decimated communities belonged so-called “Botocudos” from central-eastern Brazil. These are thought a case long-standing genetic continuity bearing strong craniometric resemblance that oldest Americans (“Paleoamericans”). Yet, little is known about their origins and relationship other Native Americans, as...
ABSTRACT After the European colonization of Americas there was a dramatic population collapse Indigenous inhabitants caused in part by introduction new pathogens. Although is much speculation on etiology Colonial epidemics, direct evidence for presence specific viruses during era lacking. To uncover diversity viral pathogens this period, we designed an enrichment assay targeting ancient DNA (aDNA) from clinical importance and applied it extracts individuals found hospital chapel (16 th c. –...
Abstract Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico’s indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions private variants functional biomedical relevance. Here we targeted the coding fraction characterized its full site frequency spectrum by 76 exomes from five populations across Mexico. Using diffusion...
Abstract Aridoamerica and Mesoamerica are two distinct cultural areas that hosted numerous pre-Hispanic civilizations between 2,500 BCE 1,521 CE. The division these regions shifted southward due to severe droughts ca. 1,100 years ago, allegedly driving demographic changes population replacement in some sites central Mexico. Here, we present shotgun genome-wide data from 12 individuals 26 mitochondrial genomes eight archaeological across Mexico, including at the shifting border of...