A5102883815- Genetic Associations and Epidemiology
- Plant and Fungal Species Descriptions
- Genomics and Phylogenetic Studies
- Plant Diversity and Evolution
- Genetic and phenotypic traits in livestock
- Genomics and Chromatin Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Systemic Lupus Erythematosus Research
- Rabies epidemiology and control
- Poxvirus research and outbreaks
- Tuberculosis Research and Epidemiology
- Livestock Farming and Management
- Cancer-related molecular mechanisms research
- Plant and animal studies
- Microbial infections and disease research
- Diabetes and associated disorders
- Sinusitis and nasal conditions
- Heavy Metal Exposure and Toxicity
- Monoclonal and Polyclonal Antibodies Research
- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- Atherosclerosis and Cardiovascular Diseases
Xiangya Hospital Central South University
2025
Chongqing University
2025
Central South University
2025
Hunan Academy of Agricultural Sciences
2021-2024
Qilu Hospital of Shandong University
2022-2024
Zhejiang University
2019-2023
Broad Institute
2016-2022
Brigham and Women's Hospital
2016-2022
Harvard University
2016-2022
University of Science and Technology of China
2022
Abstract Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating conferring protection inflammatory bowel exploiting knowledge common associated with the same disease. Through replication genotyping and imputation found that predicted variant (rs36095412, p.R179X, genotyped 11,148 ulcerative colitis patients 295,446 controls, MAF=up 0.78%) RNF186 , single-exon...
Despite significant progress in annotating the genome with experimental methods, much of regulatory noncoding remains poorly defined. Here we assert that elements may be characterized by leveraging local epigenomic signatures where specific transcription factors (TFs) are bound. To link these two features, introduce IMPACT, a annotation strategy identifies defined cell-state-specific TF binding profiles, learned from 515 chromatin and sequence annotations. We validate IMPACT using multiple...
It is important to study the genetics of complex traits in diverse populations. Here, we introduce covariate-adjusted linkage disequilibrium (LD) score regression (cov-LDSC), a method estimate SNP-heritability (${\boldsymbol{h}}_{\boldsymbol{g}}^{\mathbf{2}})$ and its enrichment homogenous admixed populations with summary statistics in-sample LD estimates. In-sample can be estimated from subset genome-wide association studies samples, allowing our applied efficiently very large cohorts. In...
Hypersensitivity reactions to drugs are often unpredictable and can be life threatening, underscoring a need for understanding their underlying mechanisms risk factors. The extent which germline genetic variation influences the of commonly reported drug allergies such as penicillin allergy remains largely unknown. We extracted data from electronic health records more than 600,000 participants UK, Estonian, Vanderbilt University Medical Center's BioVU biobanks study role in occurrence...
Cytokines are critical to human disease and attractive therapeutic targets given their widespread influence on gene regulation transcription. Defining the downstream regulatory mechanisms influenced by cytokines is central defining drug mechanisms. One promising strategy use interactions between expression quantitative trait loci (eQTLs) cytokine levels define target genes
The predominantly aquatic order Alismatales, which includes approximately 4,500 species within Araceae, Tofieldiaceae, and the core alismatid families, is a key group in investigating origin early diversification of monocots. Despite their importance, phylogenetic ambiguity regarding root Alismatales tree precludes answering questions about evolution order. Here, we sequenced first complete plastid genomes from three families this order: Potamogeton perfoliatus (Potamogetonaceae), Sagittaria...
Four Pleurotus spp. fungi (P. diamor, P. eryngii, sajor-caju, citrinopileatus) were compared for their potential to improve nutritional value of corn stover as ruminant feed. Corn was inoculated with the under solid-state conditions and results showed that sajor-caju eryngii better than other two species respect decreasing acid detergent lignin (ADL) (8.99 vs 9.88 10.16 10.46). In contrast, had lower ability degrade cellulose (13.38%). treated citrinopileatus highest crude protein (CP)...
Xiangdong black goats, indigenous to Hunan Province, China, exhibit remarkable adaptation challenging environments and possess distinct coat coloration alongside exceptional meat quality attributes. Despite their significance, comprehensive genomic investigations of this breed have been notably lacking. This study involved a examination population structure, diversity, regions selection in goats utilizing whole-genome sequencing data from 20 samples 139 published six other Chinese goat...
Patients with chronic rhinosinusitis nasal polyps (CRSwNP) and asthma comorbidity (ACRSwNP) present severe symptoms are more likely to relapse. However, the pathogenesis of ACRSwNP is not fully understood. The aim this study was explore underlying using bioinformatics approaches. ACRSwNP-related differentially expressed genes (DEGs) were identified by analysis GSE23552 dataset. clusterProfiler R package used carry out functional pathway enrichment analysis. A protein–protein interaction...
Monocots, with ca. 65,000 species in 78 families and 12 orders as classified by the Angiosperm Phylogeny Group (Angiosperm III, 2009), have traditionally been known a distinct assemblage from dicots within angiosperms are now seen lineage that diverged more basal of angiosperm groupings. In this study, third series analyzing pollen characters across angiosperms, we illustrate morphological diversity monocots analyze 19 palynological two ecological for 120 taxa 71 covering monocot 16 nine...
We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. genotyped 2,105 patients with TB and 1,320 household contacts (HHCs) who were infected Mycobacterium (M. tb) but did not develop inferred each individual's proportion native Peruvian ancestry. Our HHC study design our data on potential confounders allowed us to demonstrate increased independent socioeconomic factors. A 10% increase individual-level ancestry...
Abstract Summary Fine-mapping human leukocyte antigen (HLA) genes involved in disease susceptibility to individual alleles or amino acid residues has been challenging. Using information regarding HLA obtained from typing, imputation inference, our software expands the sequences using most recent IMGT/HLA database and prepares a dataset suitable for fine-mapping analysis. Our also provides useful functionalities, such as various association tests, visualization tools nomenclature conversion....
A healthy gut is very important for young animal development. The rumen of ruminants expands in size with the colonization microbiota by 2 months age. This process promoted alfalfa intervention. To elucidate mechanism this promotion, we performed transcriptomic analyses using a cohort 23 lambs to evaluate effects starter diets plus on development wall from pre- postweaning period. quantitative PCR were used validate selected genes that differentially expressed transcriptome mapping. We found...
Animal genetic resources are crucial for ensuring global food security. However, in recent years, a noticeable decline the diversity of livestock has occurred worldwide. This is pronounced developing countries, where management these insufficient. In current study, we performed whole genome sequencing 20 Wuxue (WX) and five Guizhou White (GW) goats. Additionally, utilized published genomes 131 samples representing different goat breeds from various regions China. We investigated compared...
Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (
Chromatin accessibility landscapes are essential for detecting regulatory elements, illustrating the corresponding networks, and, ultimately, understanding molecular basis underlying key biological processes. With advancement of sequencing technologies, a large volume chromatin data has been accumulated and integrated humans other mammals. These have greatly advanced study disease pathogenesis, cancer survival prognosis, tissue development. To advance mechanisms regulating plant traits...
Eco-friendly and efficient strategies for eliminating cadmium (Cd) phytoremediation plant residues are needed. The present study investigated the feasibility of feeding Cd accumulator maize to beef cattle. In total, 20 cattle at 6 months age were selected randomly allocated into two groups fed with 85.82% (fresh basis) (CAM) or normal (control [Con]) silage diets 107 d. Feeding CAM did not affect body weight (P = 0.24), while it decreased feed intake increased efficiency < 0.01). serum...