A5101762643- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Genetics, Aging, and Longevity in Model Organisms
- Chromatin Remodeling and Cancer
- Cancer Genomics and Diagnostics
- Nitric Oxide and Endothelin Effects
- Genomic variations and chromosomal abnormalities
- European Monetary and Fiscal Policies
- Trace Elements in Health
- Chemical Synthesis and Analysis
- Metabolism and Genetic Disorders
- Mechanisms of cancer metastasis
- Global Financial Crisis and Policies
- Genetics and Neurodevelopmental Disorders
- Breast Cancer Treatment Studies
- Pesticide Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- Glycosylation and Glycoproteins Research
- Heavy Metal Exposure and Toxicity
- Chronic Lymphocytic Leukemia Research
- Circadian rhythm and melatonin
- EU Law and Policy Analysis
- Cancer Cells and Metastasis
- Occupational Health and Safety Research
- Intraperitoneal and Appendiceal Malignancies
Hospital Universitario La Paz
2019-2025
Universidad Autónoma de Madrid
2019-2025
Universidad Veracruzana
2023
Hospital General Universitario de Ciudad Real
2022-2023
Hospital La Paz Institute for Health Research
2022
Cook Children's Health Care System
2021
Centre for Biomedical Network Research on Rare Diseases
2019-2020
Centro de Investigación Biomédica en Red
2020
Instituto de Salud Carlos III
2020
Klinikum rechts der Isar
2019
We studied the effect of intravascular activation human neutrophils on synthesis cysteinyl leukotrienes (cysLT) and formation cerebral edema in guinea-pig brains. Challenge with chemotactic formylated tripeptide fMLP (0.1 microM) neutrophil-perfused brain vitro resulted blood-brain barrier disruption associated a significant increase cysLT. Both events were completely prevented by neutrophil pretreatment specific 5-lipoxygenase (5-LO) inhibitor. Perfusion 5-LO metabolite leukotriene B4 (10...
Marker placement in a pathological node improves extirpation rates breast cancer cases with limited axillary involvement. Our goal was to assess current indications for seed marked lymph dissection (SMALND). We conducted descriptive observational study including 93 patients cN1 between January 2019 and December 2023. Seed performed under ultrasound guidance days before the procedure. Intraoperative detection achieved using probe, resection confirmed radiologically. The primary indication...
Purpose: Marker placement in a pathological node improves extirpation rates breast cancer cases with limited axillary involvement. Our goal was to assess the current indications for seed-marked lymph dissection (SMALND). Methods: We conducted descriptive observational study, including 93 patients cN1 treated between January 2019 and December 2023. Seed performed under ultrasound guidance, days before procedure. Intraoperative detection achieved using probe, resection confirmed...
Many nutritional interventions that increase lifespan are also proposed to postpone age-related declines in motor and cognitive function. Potential sources of anti-aging compounds the plants fungi have adapted extreme environments. We studied effects four commonly consumed culturally relevant Interior Alaska berry fungus species (bog blueberry, lowbush cranberry, crowberry, chaga) on decline overall health neuron function changes touch receptor morphology associated with aging. observed...
Overgrowth syndromes (OGS) comprise a heterogeneous group of disorders whose main characteristic is that either the weight, height, or head circumference are above 97th centile 2 to 3 SD mean for age and sex. Additional features, such as facial dysmorphism, developmental delay intellectual disability (ID), congenital anomalies, neurological problems an increased risk neoplasia usually associated with OGS. Genetic analysis in patients overlapping clinical features essential, distinguish...
The proximal 19p13.3 microdeletion/microduplication (prox19p13.3del/dup) syndrome is a recently described disorder with common clinical features including developmental delay, intellectual disability, speech facial dysmorphic ear defects, anomalies of the hands and feet, umbilical hernia hypotonia. While deletions are associated macrocephaly, patients duplications have microcephaly. smallest region overlap in multiple (113.5 kb) included three genes one pseudogene, suggested major role PIAS4...
Abstract Objective On April 17, 2013, a fire and subsequent explosion occurred at the West Fertilizer Company plant in West, Texas, caused extensive damage to adjacent neighborhood. This investigation described fatal nonfatal injuries by explosion. Methods Persons injured fertilizer were identified through death certificates, medical examination reports, records, survivor interviews. Data on patient characteristics, type of injury, location injury collected. Results Medical record review...
Abstract Objective: Our objective was to evaluate the impact of use a sealing device during inguinofemoral lymphadenectomy on reduction postoperative complications. Methods: A single-institution, prospective, nonrandomized study carried out. Fifteen patients with vulvar cancer underwent wide excision and inguinal between May 2017 April 2019. Five bipolar device, whereas remaining 10 received standard procedure. Postoperative complications including wound infection, seroma, lymphedema were...
<h3>Introduction/Background</h3> Between 10–15% of patients with epithelial ovarian cancer (EOC) carry a germline mutation in BRCA1/2. Different studies suggest that this population has better prognosis. The purpose our study is to analyse BRCA1/2 mutated (gBRCA1/2m) EOC and compare it wild-type (gBRCA1/2wt) population. <h3>Methodology</h3> Retrospective analysis 158 endometrioid or high-grade serous genetic performed at Hereditary Cancer Unit from February 2008 April 2020. Patients other...